Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134383687> ?p ?o ?g. }
- W2134383687 endingPage "1390" @default.
- W2134383687 startingPage "1384" @default.
- W2134383687 abstract "The predisposition to and clinical phenotype of systemic lupus erythematosus, an autoimmune disease that is associated with significant morbidity and mortality, are affected by genetic and environmental factors. This article aims to examine whether Asians have worse lupus by reviewing the literature on genetic predisposition and clinical outcomes, including major organ involvement, damage score and mortality in Asian populations compared with other ethnicities. A number of lupus nephritis susceptibility genes have been identified in Asians and White patients, with further variations among different Asian populations. Meta-analysis studies on various Fcγ receptor subtypes revealed that FcγRIIIA-F158 allele, which is associated with low binding affinity to IgG1 and IgG3, predisposed to lupus nephritis in Asian patients. Asian patients were reported to have higher rates of lupus nephritis-associated autoantibodies, lupus nephritis and more active glomerulonephritis compared with White patients. Renal outcome and the level of immunosuppressant use in Asians were comparable to Afro-American Blacks in some studies. Asians were also found to have higher overall damage scores compared with Whites. The difference in mortality between Asian patients and other ethnicities in different geographical regions was found to vary depending on socioeconomic factors such as access to health care. Poverty, education level, cultural and behavioural factors are confounders to ethnicity in determining clinical outcome of systemic lupus erythematosus." @default.
- W2134383687 created "2016-06-24" @default.
- W2134383687 creator A5036304824 @default.
- W2134383687 creator A5077141066 @default.
- W2134383687 date "2010-10-01" @default.
- W2134383687 modified "2023-10-02" @default.
- W2134383687 title "Do Asian patients have worse lupus?" @default.
- W2134383687 cites W1822501758 @default.
- W2134383687 cites W1978416104 @default.
- W2134383687 cites W1983183177 @default.
- W2134383687 cites W1990797550 @default.
- W2134383687 cites W1999098793 @default.
- W2134383687 cites W2001705242 @default.
- W2134383687 cites W2003383049 @default.
- W2134383687 cites W2003456414 @default.
- W2134383687 cites W2009574759 @default.
- W2134383687 cites W2014356691 @default.
- W2134383687 cites W2016246097 @default.
- W2134383687 cites W2017507921 @default.
- W2134383687 cites W2025724915 @default.
- W2134383687 cites W2027624699 @default.
- W2134383687 cites W2032988219 @default.
- W2134383687 cites W2036554878 @default.
- W2134383687 cites W2037461172 @default.
- W2134383687 cites W2039090134 @default.
- W2134383687 cites W2039369399 @default.
- W2134383687 cites W2053736100 @default.
- W2134383687 cites W2055114891 @default.
- W2134383687 cites W2076300443 @default.
- W2134383687 cites W2077028267 @default.
- W2134383687 cites W2087785715 @default.
- W2134383687 cites W2092016578 @default.
- W2134383687 cites W2092359569 @default.
- W2134383687 cites W2093176196 @default.
- W2134383687 cites W2099413695 @default.
- W2134383687 cites W2105713311 @default.
- W2134383687 cites W2108905161 @default.
- W2134383687 cites W2116149447 @default.
- W2134383687 cites W2119756353 @default.
- W2134383687 cites W2120562059 @default.
- W2134383687 cites W2121247695 @default.
- W2134383687 cites W2135758472 @default.
- W2134383687 cites W2147731698 @default.
- W2134383687 cites W2153151218 @default.
- W2134383687 cites W2158300364 @default.
- W2134383687 cites W2166189661 @default.
- W2134383687 cites W2167140822 @default.
- W2134383687 cites W2171453400 @default.
- W2134383687 cites W2385186104 @default.
- W2134383687 cites W4233533819 @default.
- W2134383687 doi "https://doi.org/10.1177/0961203310375832" @default.
- W2134383687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20947546" @default.
- W2134383687 hasPublicationYear "2010" @default.
- W2134383687 type Work @default.
- W2134383687 sameAs 2134383687 @default.
- W2134383687 citedByCount "47" @default.
- W2134383687 countsByYear W21343836872012 @default.
- W2134383687 countsByYear W21343836872013 @default.
- W2134383687 countsByYear W21343836872014 @default.
- W2134383687 countsByYear W21343836872015 @default.
- W2134383687 countsByYear W21343836872016 @default.
- W2134383687 countsByYear W21343836872017 @default.
- W2134383687 countsByYear W21343836872018 @default.
- W2134383687 countsByYear W21343836872019 @default.
- W2134383687 countsByYear W21343836872020 @default.
- W2134383687 countsByYear W21343836872021 @default.
- W2134383687 countsByYear W21343836872022 @default.
- W2134383687 countsByYear W21343836872023 @default.
- W2134383687 crossrefType "journal-article" @default.
- W2134383687 hasAuthorship W2134383687A5036304824 @default.
- W2134383687 hasAuthorship W2134383687A5077141066 @default.
- W2134383687 hasConcept C126322002 @default.
- W2134383687 hasConcept C137403100 @default.
- W2134383687 hasConcept C144024400 @default.
- W2134383687 hasConcept C159654299 @default.
- W2134383687 hasConcept C163764329 @default.
- W2134383687 hasConcept C19165224 @default.
- W2134383687 hasConcept C203014093 @default.
- W2134383687 hasConcept C2775915377 @default.
- W2134383687 hasConcept C2776912625 @default.
- W2134383687 hasConcept C2777058396 @default.
- W2134383687 hasConcept C2779134260 @default.
- W2134383687 hasConcept C2779912601 @default.
- W2134383687 hasConcept C67636389 @default.
- W2134383687 hasConcept C71924100 @default.
- W2134383687 hasConcept C77350462 @default.
- W2134383687 hasConceptScore W2134383687C126322002 @default.
- W2134383687 hasConceptScore W2134383687C137403100 @default.
- W2134383687 hasConceptScore W2134383687C144024400 @default.
- W2134383687 hasConceptScore W2134383687C159654299 @default.
- W2134383687 hasConceptScore W2134383687C163764329 @default.
- W2134383687 hasConceptScore W2134383687C19165224 @default.
- W2134383687 hasConceptScore W2134383687C203014093 @default.
- W2134383687 hasConceptScore W2134383687C2775915377 @default.
- W2134383687 hasConceptScore W2134383687C2776912625 @default.
- W2134383687 hasConceptScore W2134383687C2777058396 @default.
- W2134383687 hasConceptScore W2134383687C2779134260 @default.
- W2134383687 hasConceptScore W2134383687C2779912601 @default.