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- W2134394793 abstract "The structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase (ALAD) complexed with the irreversible inhibitor 4,7-dioxosebacic acid has been solved. The inhibitor binds by forming Schiff-base linkages with lysines 200 and 253 at the active site. The structure reported here provides a definition of the interactions made by both of the substrate molecules (A-side and P-side substrates) with the C. vibrioforme ALAD and is compared and contrasted with structures of the same inhibitor bound to Escherichia coli and yeast ALAD. The structure suggests why 4,7-dioxosebacic acid is a better inhibitor of the zinc-dependent ALADs than of the zinc-independent ALADs." @default.
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- W2134394793 date "2005-11-19" @default.
- W2134394793 modified "2023-10-17" @default.
- W2134394793 title "Structure of<i>Chlorobium vibrioforme</i>5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor" @default.
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- W2134394793 doi "https://doi.org/10.1107/s0907444905030350" @default.
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