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• W2134398511 abstract "The nucleus accumbens (NAc) is gaining interest as a target for deep brain stimulation (DBS) in refractory neuropsychiatric disorders with impulsivity as core symptom. The nucleus accumbens is composed of two subterritories, core and shell, which have different anatomical connections. In animal models, it has been shown that DBS of the NAc changes impulsive action. Here, we tested the hypothesis that a change in impulsive action by DBS of the NAc is associated with changes in dopamine levels. Rats received stimulating electrodes either in the NAc core or shell, and underwent behavioral testing in a reaction time task. In addition, in a second experiment, the effect of DBS of the NAc core and shell on extracellular dopamine and serotonin levels was assessed in the NAc and medial prefrontal cortex. Control subjects received sham surgery. We have found that DBS of the NAc shell stimulation induced more impulsive action but less perseverative checking. These effects were associated with increased levels of dopamine and serotonin in the NAc, but not in the medial prefrontal cortex. DBS of the NAc core had no effect on impulsive action, but decreased perseverative responses indicative of a better impulse control. In these subjects, no effects were found on neurotransmitter levels. Our data point out that DBS of the NAc shell has negative effects on impulsive action which is accompanied by increases of dopamine and serotonin levels in the NAc, whereas DBS of the NAc core has beneficial behavioral effects." @default.
• W2134398511 created "2016-06-24" @default.
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• W2134398511 date "2010-10-01" @default.
• W2134398511 modified "2023-10-11" @default.
• W2134398511 title "Deep brain stimulation of the nucleus accumbens shell increases impulsive behavior and tissue levels of dopamine and serotonin" @default.
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• W2134398511 cites W1964795016 @default.
• W2134398511 cites W1977947329 @default.
• W2134398511 cites W1982091038 @default.
• W2134398511 cites W1984785177 @default.
• W2134398511 cites W1985174354 @default.
• W2134398511 cites W1987024745 @default.
• W2134398511 cites W1994067708 @default.
• W2134398511 cites W1994561821 @default.
• W2134398511 cites W1996084072 @default.
• W2134398511 cites W1997388974 @default.
• W2134398511 cites W1997651287 @default.
• W2134398511 cites W2003720775 @default.
• W2134398511 cites W2006145908 @default.
• W2134398511 cites W2008413772 @default.
• W2134398511 cites W2008511677 @default.
• W2134398511 cites W2012635324 @default.
• W2134398511 cites W2013622904 @default.
• W2134398511 cites W2014236862 @default.
• W2134398511 cites W2014415095 @default.
• W2134398511 cites W2014459415 @default.
• W2134398511 cites W2014536531 @default.
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• W2134398511 cites W2021190392 @default.
• W2134398511 cites W2026995370 @default.
• W2134398511 cites W2028127185 @default.
• W2134398511 cites W2029111326 @default.
• W2134398511 cites W2030871689 @default.
• W2134398511 cites W2032844445 @default.
• W2134398511 cites W2033467754 @default.
• W2134398511 cites W2043729058 @default.
• W2134398511 cites W2046705768 @default.
• W2134398511 cites W2049324372 @default.
• W2134398511 cites W2051004303 @default.
• W2134398511 cites W2052329772 @default.
• W2134398511 cites W2056093189 @default.
• W2134398511 cites W2057787317 @default.
• W2134398511 cites W2062049551 @default.
• W2134398511 cites W2066396930 @default.
• W2134398511 cites W2069257507 @default.
• W2134398511 cites W2073003311 @default.
• W2134398511 cites W2073346596 @default.
• W2134398511 cites W2073718251 @default.
• W2134398511 cites W2075588319 @default.
• W2134398511 cites W2079336726 @default.
• W2134398511 cites W2080336361 @default.
• W2134398511 cites W2083845601 @default.
• W2134398511 cites W2092533548 @default.
• W2134398511 cites W2112222184 @default.
• W2134398511 cites W2115857124 @default.
• W2134398511 cites W2121278129 @default.
• W2134398511 cites W2124106518 @default.
• W2134398511 cites W2124407078 @default.
• W2134398511 cites W2125080419 @default.
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• W2134398511 cites W2149885167 @default.
• W2134398511 cites W2153557787 @default.
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• W2134398511 cites W2320756557 @default.
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• W2134398511 doi "https://doi.org/10.1016/j.expneurol.2010.06.022" @default.
• W2134398511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20615406" @default.
• W2134398511 hasPublicationYear "2010" @default.
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