Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134400516> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2134400516 endingPage "64" @default.
- W2134400516 startingPage "4057" @default.
- W2134400516 abstract "The use of 1,25-dihydroxyvitamin D3 as an antiproliferative agent in the treatment of cancer is limited by its hypercalcemic effects. Analogues with equivalent or greater antiproliferative activities but smaller hypercalcemic effects have been developed. The antiproliferative effects of 1,25-dihydroxyvitamin D3 and four analogues were studied in HT-29 and SW620 human colon cancer cell lines, moderate and low expressors of the vitamin D receptor, respectively. HT-29 is a primary, moderately differentiated, cell line, while SW620 is metastatic and poorly differentiated. Growth curve studies, proliferation assays, and clonogenic assays were used to assess the antiproliferative effects of 1,25-dihydroxyvitamin D3, 1,25-dihydroxy-16-ene-23-yne-D3, 1,25-dihydroxy-26,27-hexafluoro-16-ene-23-yne-D3, 1,25-dihydroxy-16,23E-diene-26,27-hexafluoro-D3, and 1,25-dihydroxy-16,23Z-diene-26,27-hexafluoro-D3. Growth of HT-29 cells was significantly inhibited by all four analogues at 10(-8) M (P < 0.05). Analogues 1,25-dihydroxy-26,27-hexafluoro-16-ene-23-yne-D3, 1,25-dihydroxy-16,23E-diene-26,27-hexafluoro-D3, and 1,25-dihydroxy-16,23Z-diene-26,27-hexafluoro-D3 were 2 times as potent as analogue 1,25-dihydroxy-16-ene-23-yne-D3 and 1,25-dihydroxyvitamin D3. SW620 cells did not show any growth inhibition with any of the compounds tested. The affinities of the three most potent analogues for the vitamin D receptor were similar to that of 1,25-dihydroxyvitamin D3, while that of analogue 1,25-dihydroxy-16-ene-23-yne-D3 was lower. These results demonstrate that, as in leukemic cells, analogues of 1,25-dihydroxyvitamin D3 are potent antiproliferative agents in colon cancer cells and this activity is most likely mediated through the vitamin D receptor." @default.
- W2134400516 created "2016-06-24" @default.
- W2134400516 creator A5004801243 @default.
- W2134400516 creator A5012795454 @default.
- W2134400516 creator A5030668335 @default.
- W2134400516 creator A5034479183 @default.
- W2134400516 creator A5034897584 @default.
- W2134400516 creator A5067804156 @default.
- W2134400516 creator A5080136543 @default.
- W2134400516 creator A5087234626 @default.
- W2134400516 date "1994-08-01" @default.
- W2134400516 modified "2023-10-17" @default.
- W2134400516 title "Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3." @default.
- W2134400516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8033137" @default.
- W2134400516 hasPublicationYear "1994" @default.
- W2134400516 type Work @default.
- W2134400516 sameAs 2134400516 @default.
- W2134400516 citedByCount "41" @default.
- W2134400516 countsByYear W21344005162013 @default.
- W2134400516 countsByYear W21344005162015 @default.
- W2134400516 countsByYear W21344005162016 @default.
- W2134400516 countsByYear W21344005162017 @default.
- W2134400516 countsByYear W21344005162019 @default.
- W2134400516 countsByYear W21344005162021 @default.
- W2134400516 countsByYear W21344005162022 @default.
- W2134400516 countsByYear W21344005162023 @default.
- W2134400516 crossrefType "journal-article" @default.
- W2134400516 hasAuthorship W2134400516A5004801243 @default.
- W2134400516 hasAuthorship W2134400516A5012795454 @default.
- W2134400516 hasAuthorship W2134400516A5030668335 @default.
- W2134400516 hasAuthorship W2134400516A5034479183 @default.
- W2134400516 hasAuthorship W2134400516A5034897584 @default.
- W2134400516 hasAuthorship W2134400516A5067804156 @default.
- W2134400516 hasAuthorship W2134400516A5080136543 @default.
- W2134400516 hasAuthorship W2134400516A5087234626 @default.
- W2134400516 hasConcept C117262875 @default.
- W2134400516 hasConcept C121608353 @default.
- W2134400516 hasConcept C126322002 @default.
- W2134400516 hasConcept C134018914 @default.
- W2134400516 hasConcept C1491633281 @default.
- W2134400516 hasConcept C170493617 @default.
- W2134400516 hasConcept C179639408 @default.
- W2134400516 hasConcept C185592680 @default.
- W2134400516 hasConcept C2779707156 @default.
- W2134400516 hasConcept C526805850 @default.
- W2134400516 hasConcept C54355233 @default.
- W2134400516 hasConcept C55493867 @default.
- W2134400516 hasConcept C62112901 @default.
- W2134400516 hasConcept C71240020 @default.
- W2134400516 hasConcept C71924100 @default.
- W2134400516 hasConcept C81885089 @default.
- W2134400516 hasConcept C86803240 @default.
- W2134400516 hasConcept C98274493 @default.
- W2134400516 hasConceptScore W2134400516C117262875 @default.
- W2134400516 hasConceptScore W2134400516C121608353 @default.
- W2134400516 hasConceptScore W2134400516C126322002 @default.
- W2134400516 hasConceptScore W2134400516C134018914 @default.
- W2134400516 hasConceptScore W2134400516C1491633281 @default.
- W2134400516 hasConceptScore W2134400516C170493617 @default.
- W2134400516 hasConceptScore W2134400516C179639408 @default.
- W2134400516 hasConceptScore W2134400516C185592680 @default.
- W2134400516 hasConceptScore W2134400516C2779707156 @default.
- W2134400516 hasConceptScore W2134400516C526805850 @default.
- W2134400516 hasConceptScore W2134400516C54355233 @default.
- W2134400516 hasConceptScore W2134400516C55493867 @default.
- W2134400516 hasConceptScore W2134400516C62112901 @default.
- W2134400516 hasConceptScore W2134400516C71240020 @default.
- W2134400516 hasConceptScore W2134400516C71924100 @default.
- W2134400516 hasConceptScore W2134400516C81885089 @default.
- W2134400516 hasConceptScore W2134400516C86803240 @default.
- W2134400516 hasConceptScore W2134400516C98274493 @default.
- W2134400516 hasIssue "15" @default.
- W2134400516 hasLocation W21344005161 @default.
- W2134400516 hasOpenAccess W2134400516 @default.
- W2134400516 hasPrimaryLocation W21344005161 @default.
- W2134400516 hasRelatedWork W113849494 @default.
- W2134400516 hasRelatedWork W1501174574 @default.
- W2134400516 hasRelatedWork W1965658335 @default.
- W2134400516 hasRelatedWork W1969560812 @default.
- W2134400516 hasRelatedWork W2013850508 @default.
- W2134400516 hasRelatedWork W2014868170 @default.
- W2134400516 hasRelatedWork W202472106 @default.
- W2134400516 hasRelatedWork W2127568059 @default.
- W2134400516 hasRelatedWork W2364672671 @default.
- W2134400516 hasRelatedWork W2385874192 @default.
- W2134400516 hasVolume "54" @default.
- W2134400516 isParatext "false" @default.
- W2134400516 isRetracted "false" @default.
- W2134400516 magId "2134400516" @default.
- W2134400516 workType "article" @default.