FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134449012> ?p ?o ?g. }

• W2134449012 abstract "Many pathological conditions, like sleep apnea (SA), preeclampsia, high altitude sickness, and chronic obstructive pulmonary disease, that cause intermittent or chronic hypoxia, are often associated with the development of either systemic or pulmonary hypertension.1 Mechanisms sensing hypoxia may be important contributors to the development of pulmonary hypertension and to tissue injury and repair associated with hypertensive disease and in integrated aspects of cardiovascular function. This review will focus on highlighting how some of the better documented oxygen-sensing mechanisms associated with vascular regulation could be influenced by poorly understood interactions between hypoxia and hypertension. It will also consider some of the identified integrated interactions between hypoxia and hypertensive disease processes that could contribute to the progression of disease processes, such as renal hypertension.High altitude and chronic obstructive pulmonary disease are thought to promote pulmonary hypertension by exposing the pulmonary circulation to chronic hypoxia as a result of the low partial pressure of oxygen at high altitude and increases in the diffusion distance for oxygen, respectively.2,3 Although high altitude can initially promote increased systemic blood pressure, this change appears to reverse with time.4 Interestingly, hypobaric hypoxia conditions of high altitude were observed to prevent the development of hypertension and skeletal muscle arteriolar rarefaction in spontaneously hypertensive rats.5 Living at high altitude seems to lower blood pressure only in children,6 and it did not appear to attenuate hypertension in obese adults consuming high-fat diets.7 Based on studies in animal models of acute and chronic hypoxia, hypoxic pulmonary vasoconstriction (HPV) is initially activated. Eventually endothelial dysfunction associated with a loss of NO and increased reactive oxygen species (ROS), endothelin, serotonin, and contractile prostaglandins contribute to maintaining elevated pulmonary artery pressure through increased intracellular Ca2+ levels and rho kinase-associated myofilament Ca2+ sensitivity.8 Although …" @default.
• W2134449012 created "2016-06-24" @default.
• W2134449012 creator A5033512267 @default.
• W2134449012 creator A5040548588 @default.
• W2134449012 date "2012-08-01" @default.
• W2134449012 modified "2023-09-24" @default.
• W2134449012 title "Relationships Between Vascular Oxygen Sensing Mechanisms and Hypertensive Disease Processes" @default.
• W2134449012 cites W1524769511 @default.
• W2134449012 cites W1849560193 @default.
• W2134449012 cites W1968119937 @default.
• W2134449012 cites W1973313407 @default.
• W2134449012 cites W1976787396 @default.
• W2134449012 cites W1978214583 @default.
• W2134449012 cites W1985014243 @default.
• W2134449012 cites W1988154462 @default.
• W2134449012 cites W1990347775 @default.
• W2134449012 cites W1996630410 @default.
• W2134449012 cites W2004139828 @default.
• W2134449012 cites W2005406090 @default.
• W2134449012 cites W2006347607 @default.
• W2134449012 cites W2023184179 @default.
• W2134449012 cites W2025593289 @default.
• W2134449012 cites W2025992804 @default.
• W2134449012 cites W2031935406 @default.
• W2134449012 cites W2032462309 @default.
• W2134449012 cites W2033670972 @default.
• W2134449012 cites W2042592767 @default.
• W2134449012 cites W2046012789 @default.
• W2134449012 cites W2049151407 @default.
• W2134449012 cites W2056953078 @default.
• W2134449012 cites W2062002285 @default.
• W2134449012 cites W2062786004 @default.
• W2134449012 cites W2062946803 @default.
• W2134449012 cites W2065525967 @default.
• W2134449012 cites W2067234482 @default.
• W2134449012 cites W2067561562 @default.
• W2134449012 cites W2070050669 @default.
• W2134449012 cites W2071912153 @default.
• W2134449012 cites W2082363481 @default.
• W2134449012 cites W2083053167 @default.
• W2134449012 cites W2083695339 @default.
• W2134449012 cites W2087377825 @default.
• W2134449012 cites W2088161934 @default.
• W2134449012 cites W2088727431 @default.
• W2134449012 cites W2090159456 @default.
• W2134449012 cites W2090289968 @default.
• W2134449012 cites W2090992254 @default.
• W2134449012 cites W2096226619 @default.
• W2134449012 cites W2101707570 @default.
• W2134449012 cites W2105891302 @default.
• W2134449012 cites W2112342981 @default.
• W2134449012 cites W2112861506 @default.
• W2134449012 cites W2117185007 @default.
• W2134449012 cites W2119902428 @default.
• W2134449012 cites W2120788437 @default.
• W2134449012 cites W2128455103 @default.
• W2134449012 cites W2128940917 @default.
• W2134449012 cites W2129204179 @default.
• W2134449012 cites W2134256354 @default.
• W2134449012 cites W2136242238 @default.
• W2134449012 cites W2144845371 @default.
• W2134449012 cites W2146713119 @default.
• W2134449012 cites W2150739502 @default.
• W2134449012 cites W2152333840 @default.
• W2134449012 cites W2162514162 @default.
• W2134449012 cites W2166945629 @default.
• W2134449012 cites W2168524544 @default.
• W2134449012 cites W2169220357 @default.
• W2134449012 cites W2184804607 @default.
• W2134449012 cites W2235933797 @default.
• W2134449012 doi "https://doi.org/10.1161/hypertensionaha.112.190702" @default.
• W2134449012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3401320" @default.
• W2134449012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22710643" @default.
• W2134449012 hasPublicationYear "2012" @default.
• W2134449012 type Work @default.
• W2134449012 sameAs 2134449012 @default.
• W2134449012 citedByCount "11" @default.
• W2134449012 countsByYear W21344490122013 @default.
• W2134449012 countsByYear W21344490122014 @default.
• W2134449012 countsByYear W21344490122015 @default.
• W2134449012 countsByYear W21344490122016 @default.
• W2134449012 countsByYear W21344490122017 @default.
• W2134449012 countsByYear W21344490122020 @default.
• W2134449012 crossrefType "journal-article" @default.
• W2134449012 hasAuthorship W2134449012A5033512267 @default.
• W2134449012 hasAuthorship W2134449012A5040548588 @default.
• W2134449012 hasBestOaLocation W21344490121 @default.
• W2134449012 hasConcept C105702510 @default.
• W2134449012 hasConcept C126322002 @default.
• W2134449012 hasConcept C164705383 @default.
• W2134449012 hasConcept C178790620 @default.
• W2134449012 hasConcept C185592680 @default.
• W2134449012 hasConcept C2779134260 @default.
• W2134449012 hasConcept C2780930700 @default.
• W2134449012 hasConcept C29323129 @default.
• W2134449012 hasConcept C540031477 @default.
• W2134449012 hasConcept C57190642 @default.
• W2134449012 hasConcept C71924100 @default.
• W2134449012 hasConcept C7836513 @default.
• W2134449012 hasConcept C8240015 @default.

• next