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- W2134460244 abstract "5-Oxo-L-prolinase catalyzes the virtually complete hydrolysis of 5-oxo-L-proline (L-pyroglutamate) to L-glutamate. The thermodynamic driving force for this endergonic amide hydrolysis is supplied by the coupled stoichiometric hydrolysis of ATP to ADP and Pi. We report here that the efficiency of the coupling between nucleotide and amide hydrolysis is dependent on the nucleotide base. Thus, with both ATP and dATP there is one to one stoichiometry between nucleotide cleavage and 5-oxoproline hydrolysis. With ITP, GTP, or UTP, however, the hydrolysis of NTP exceeds amide hydrolysis by 6 to 50-fold. In the absence of 5- oxoproline, the enzyme catalyzes a slow ATPase reaction, but it catalyzes very rapid ITPase, GTPase and UTPase reactions. These NTPase reactions, which under some conditions are faster than the ATP-mediated overall coupled reaction, are inhibited by 5-oxoproline and by analogs of 5-oxoproline that bind to the enzyme." @default.
- W2134460244 created "2016-06-24" @default.
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- W2134460244 date "1976-06-01" @default.
- W2134460244 modified "2023-09-27" @default.
- W2134460244 title "Dependence of energy coupling on nucleotide base structure in the reaction catalyzed by 5-oxo-L-prolinase" @default.
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- W2134460244 doi "https://doi.org/10.1016/0006-291x(76)90657-4" @default.
- W2134460244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/938527" @default.
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