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• W2134471235 abstract "The causative agents of sexually transmitted diseases are seldom involved in kidney disease. Only a handful of cases have been described of pyelonephritis or immune complex-mediated glomerulonephritis in patients with gonococcal infections [1,2]. The most important association is present in human immunodeficiency virus (HIV)-infected patients: HIVassociated nephropathy was diagnosed at autopsy in 12% of HIV-infected black people and in 1% of HIVinfected non-black people [3]. A clear relationship between hepatitis C virus infection and glomerulonephritis has been demonstrated. Cryoglobulinaemic membranoproliferative glomerulonephritis and membranous nephropathy occur in 2.6 and 1.8% of cases, respectively [4]. Hepatitis B virus infection is also associated with glomerulonephritis, but the prevalence is not known. However, it is estimated to be low because of the low endemicity in most Western countries. Nephropathy associated with syphilis seems to have been more common in the past, presenting as nephrotic syndrome caused by immune complex-mediated membranous or mesangial glomerulonephritis. Nowadays, the possibility of renal involvement in syphilis is no longer even mentioned in textbooks of infectious diseases [5]. Interstitial syphilitic nephritis has been described in the literature only once, by Docolomansky et al., in the Slovakian language, without an abstract in Medline [6]. In this issue of Nephrology Dialysis Transplantation, Chen et al. present a case of salt-losing nephropathy as the only symptom of interstitial nephritis, and they suggest a causative role for syphilis [7]. Let us therefore take a closer look at syphilis and Treponema pallidum, the organism causing it, in the light of this particular case. Clinical features" @default.
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• W2134471235 date "2005-05-03" @default.
• W2134471235 modified "2023-09-23" @default.
• W2134471235 title "Did syphilis truly strike the kidneys this time?" @default.
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• W2134471235 doi "https://doi.org/10.1093/ndt/gfh792" @default.
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