Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134489063> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2134489063 endingPage "907" @default.
- W2134489063 startingPage "899" @default.
- W2134489063 abstract "Autoimmune diseases are the third largest category of illness in the industrialized world, following cardiovascular diseases and cancers. Among them, type 1 diabetes, also named autoimmune diabetes, afflicts 10 million people worldwide. This disease is caused by autoimmunity-mediated destruction of pancreatic β-cells, leading to insulin deficiency, hyperglycemia and complications. Currently, there is no cure for type 1 diabetes. Insulin injection is the only medication; however, it accompanies serious medical complications. Current strategies to cure type 1 diabetes include immunotherapy, replacement therapy, and combination therapy. Despite recent advances in anti-diabetic strategies, no strategy is clinically successful. How to cure type 1 diabetes without undesirable side effects still remains a formidable challenge in drug research and development. Plants provide an extraordinary source of natural medicines for different diseases. Moreover, secondary metabolites of plant origin serve as an invaluable chemical library for drug discovery and current medicinal chemistry in the pharmaceutical industry. Over the past 25 years, 50% of prescription drugs have been developed from natural products and their derivatives. In this article, we review more than 20 plant compounds and extracts reported in the literature to prevent and treat type-1 diabetes. Emphasis is placed on their chemistry and biology in terms of regulation of immune cells and pancreatic β-cells. We summarize recent progress in understanding the biological actions, mechanisms and therapeutic potential of the compounds and extracts of plant origin in type 1 diabetes. New views on phytocompound-based strategies for prevention and treatment of type 1 diabetes are also discussed." @default.
- W2134489063 created "2016-06-24" @default.
- W2134489063 creator A5027852050 @default.
- W2134489063 creator A5030272301 @default.
- W2134489063 creator A5045872446 @default.
- W2134489063 creator A5081317577 @default.
- W2134489063 creator A5090220753 @default.
- W2134489063 date "2013-02-01" @default.
- W2134489063 modified "2023-09-25" @default.
- W2134489063 title "Natural Cures for Type 1 Diabetes: A Review of Phytochemicals, Biological Actions, and Clinical Potential" @default.
- W2134489063 doi "https://doi.org/10.2174/0929867311320070006" @default.
- W2134489063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23210779" @default.
- W2134489063 hasPublicationYear "2013" @default.
- W2134489063 type Work @default.
- W2134489063 sameAs 2134489063 @default.
- W2134489063 citedByCount "9" @default.
- W2134489063 countsByYear W21344890632014 @default.
- W2134489063 countsByYear W21344890632015 @default.
- W2134489063 countsByYear W21344890632016 @default.
- W2134489063 countsByYear W21344890632018 @default.
- W2134489063 countsByYear W21344890632019 @default.
- W2134489063 countsByYear W21344890632022 @default.
- W2134489063 crossrefType "journal-article" @default.
- W2134489063 hasAuthorship W2134489063A5027852050 @default.
- W2134489063 hasAuthorship W2134489063A5030272301 @default.
- W2134489063 hasAuthorship W2134489063A5045872446 @default.
- W2134489063 hasAuthorship W2134489063A5081317577 @default.
- W2134489063 hasAuthorship W2134489063A5090220753 @default.
- W2134489063 hasConcept C126322002 @default.
- W2134489063 hasConcept C134018914 @default.
- W2134489063 hasConcept C177713679 @default.
- W2134489063 hasConcept C203014093 @default.
- W2134489063 hasConcept C2426938 @default.
- W2134489063 hasConcept C2777180221 @default.
- W2134489063 hasConcept C2779134260 @default.
- W2134489063 hasConcept C2779306644 @default.
- W2134489063 hasConcept C2780035454 @default.
- W2134489063 hasConcept C2780130043 @default.
- W2134489063 hasConcept C2781232474 @default.
- W2134489063 hasConcept C555293320 @default.
- W2134489063 hasConcept C60644358 @default.
- W2134489063 hasConcept C71924100 @default.
- W2134489063 hasConcept C86803240 @default.
- W2134489063 hasConcept C98274493 @default.
- W2134489063 hasConceptScore W2134489063C126322002 @default.
- W2134489063 hasConceptScore W2134489063C134018914 @default.
- W2134489063 hasConceptScore W2134489063C177713679 @default.
- W2134489063 hasConceptScore W2134489063C203014093 @default.
- W2134489063 hasConceptScore W2134489063C2426938 @default.
- W2134489063 hasConceptScore W2134489063C2777180221 @default.
- W2134489063 hasConceptScore W2134489063C2779134260 @default.
- W2134489063 hasConceptScore W2134489063C2779306644 @default.
- W2134489063 hasConceptScore W2134489063C2780035454 @default.
- W2134489063 hasConceptScore W2134489063C2780130043 @default.
- W2134489063 hasConceptScore W2134489063C2781232474 @default.
- W2134489063 hasConceptScore W2134489063C555293320 @default.
- W2134489063 hasConceptScore W2134489063C60644358 @default.
- W2134489063 hasConceptScore W2134489063C71924100 @default.
- W2134489063 hasConceptScore W2134489063C86803240 @default.
- W2134489063 hasConceptScore W2134489063C98274493 @default.
- W2134489063 hasIssue "7" @default.
- W2134489063 hasLocation W21344890631 @default.
- W2134489063 hasLocation W21344890632 @default.
- W2134489063 hasOpenAccess W2134489063 @default.
- W2134489063 hasPrimaryLocation W21344890631 @default.
- W2134489063 hasRelatedWork W1484311423 @default.
- W2134489063 hasRelatedWork W199962162 @default.
- W2134489063 hasRelatedWork W2081405889 @default.
- W2134489063 hasRelatedWork W2161035911 @default.
- W2134489063 hasRelatedWork W2782732109 @default.
- W2134489063 hasRelatedWork W2967084704 @default.
- W2134489063 hasRelatedWork W3041563066 @default.
- W2134489063 hasRelatedWork W3153783058 @default.
- W2134489063 hasRelatedWork W4304957541 @default.
- W2134489063 hasRelatedWork W4313279502 @default.
- W2134489063 hasVolume "20" @default.
- W2134489063 isParatext "false" @default.
- W2134489063 isRetracted "false" @default.
- W2134489063 magId "2134489063" @default.
- W2134489063 workType "article" @default.