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- W2134500402 abstract "Apoptosis of bystander uninfected CD4+ T lymphocytes by neighboring HIV-infected cells is observed in cell culture and in lymphoid tissue of HIV-infected individuals. This study addresses whether antigen-presenting cells such as human macrophages mediate apoptosis of CD4+ T cells from HIV-infected individuals. Uninfected human macrophages, and to a larger degree, HIV-infected macrophages mediate apoptosis of T cells from HIV-infected, but not from uninfected control individuals. This macrophage-dependent killing targets CD4+, but not CD8+ T lymphocytes from HIV-infected individuals, and direct contact between macrophages and lymphocytes is required. Additional analyses indicated that the apoptosis-inducing ligands, FasL and tumor necrosis factor (TNF), mediate this macrophage-induced apoptosis of CD4+ T cells. These results support a role for macrophage-associated FasL and TNF in the selective depletion of CD4+ T cells in HIV-infected individuals." @default.
- W2134500402 created "2016-06-24" @default.
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- W2134500402 date "1997-01-01" @default.
- W2134500402 modified "2023-09-26" @default.
- W2134500402 title "Macrophage-dependent Apoptosis of CD4+ T Lymphocytes from HIV-infected Individuals Is Mediated by FasL and Tumor Necrosis Factor" @default.
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- W2134500402 doi "https://doi.org/10.1084/jem.185.1.55" @default.
- W2134500402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2196110" @default.
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