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• W2134504265 abstract "Backgrounds . TSP-1 is a glycoprotein that functions in the biology of bladder cancer. We investigated the relationship between the distribution of TSP-1 -1223 A/G polymorphism (rs2169830) and the clinical characteristics of bladder cancer. Materials and Methods . TaqMan assay was performed to determine the genotype of 609 cases and 670 control subjects in a Chinese population. Logistic regression was used to assess the association between the polymorphism and the risk of bladder cancer. Quantitative real-time polymerase chain reaction was performed to determine TSP-1 mRNA expression. Survival curves were generated using the Kaplan-Meier method. Results . No significant differences were detected in the genotype frequencies of healthy control subjects and patients with bladder cancer. By contrast, the time until the first recurrence differed significantly between genotypes (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.017</mml:mn></mml:mrow></mml:math>). The expression of TSP-1 mRNA in bladder cancer tissues was lower in patients with an AG genotype than in those with an AA genotype. The lowest expression was observed in patients with a GG genotype. Conclusions . In conclusion, TSP-1 -1223 A/G polymorphism may contribute to the recurrence of bladder cancer in Chinese population." @default.
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• W2134504265 date "2013-01-01" @default.
• W2134504265 modified "2023-10-11" @default.
• W2134504265 title "TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population" @default.
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• W2134504265 doi "https://doi.org/10.1155/2013/473242" @default.
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