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- W2134513144 abstract "Abstract Rheumatoid arthritis ( RA ) is a common autoimmune disease with a strong genetic component. Numerous aberrant immune responses have been described during the evolution of the disease. In later years, the appearance of anti‐citrullinated protein antibodies ( ACPAs ) has become a hallmark for the diagnosis and prognosis of RA . The post‐translational transformation of arginine residues of proteins and peptides into citrulline (citrullination) is a natural process in the body, but for unknown reasons autoreactivity towards citrullinated residues may develop in disposed individuals. ACPAs are often found years before clinical manifestations. ACPAs are present in about 70% of RA patients and constitute an important disease marker, distinguishing patient groups with different prognoses and different responses to various treatments. Inside the human leukocyte antigen ( HLA ) region, some HLA‐DRB1 alleles are strongly associated with their production. Genome‐wide association studies in large patient cohorts have defined a great number of single nucleotide polymorphisms ( SNPs ) outside of the HLA region that are associated with ACPA positive ( ACPA +) RA . The SNPs are generally located close to or within genes involved in the immune response or signal transduction in immune cells. Some environmental factors such as tobacco smoking are also positively correlated with ACPA production. In this review, we will describe the genes and loci associated with ACPA + RA or ACPA − RA and attempt to clarify their potential role in the development of the disease." @default.
- W2134513144 created "2016-06-24" @default.
- W2134513144 creator A5018478650 @default.
- W2134513144 creator A5049764141 @default.
- W2134513144 creator A5086550404 @default.
- W2134513144 creator A5089742573 @default.
- W2134513144 date "2012-07-26" @default.
- W2134513144 modified "2023-10-16" @default.
- W2134513144 title "New insights into the genetics of immune responses in rheumatoid arthritis" @default.
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- W2134513144 doi "https://doi.org/10.1111/j.1399-0039.2012.01939.x" @default.
- W2134513144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22835281" @default.
- W2134513144 hasPublicationYear "2012" @default.
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