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- W2134536161 abstract "Platelets are essential for haemostasis, and thrombocytopenia (platelet counts <150 × 10(9) /l) is a major clinical problem encountered across a number of conditions, including immune thrombocytopenic purpura, myelodysplastic syndromes, chemotherapy, aplastic anaemia, human immunodeficiency virus infection, complications during pregnancy and delivery, and surgery. Circulating blood platelets are specialized cells that function to prevent bleeding and minimize blood vessel injury. Platelets circulate in their quiescent form, and upon stimulation, activate to release their granule contents and spread on the affected tissue to create a physical barrier that prevents blood loss. The current model of platelet formation states that large progenitor cells in the bone marrow, called megakaryocytes, release platelets by extending long, branching processes, designated proplatelets, into sinusoidal blood vessels. This review will focus on different factors that impact megakaryocyte development, proplatelet formation and platelet release. It will highlight recent studies on thrombopoeitin-dependent megakaryocyte maturation, endomitosis and granule formation, cytoskeletal contributions to proplatelet formation, the role of apoptosis, and terminal platelet formation and release." @default.
- W2134536161 created "2016-06-24" @default.
- W2134536161 creator A5010140123 @default.
- W2134536161 creator A5034804379 @default.
- W2134536161 creator A5091460302 @default.
- W2134536161 date "2014-02-06" @default.
- W2134536161 modified "2023-10-13" @default.
- W2134536161 title "Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation" @default.
- W2134536161 cites W144754814 @default.
- W2134536161 cites W1492619899 @default.
- W2134536161 cites W1561221378 @default.
- W2134536161 cites W1565725475 @default.
- W2134536161 cites W1581255805 @default.
- W2134536161 cites W158506035 @default.
- W2134536161 cites W1602522526 @default.
- W2134536161 cites W1662539477 @default.
- W2134536161 cites W168208124 @default.
- W2134536161 cites W1829315865 @default.
- W2134536161 cites W1836124358 @default.
- W2134536161 cites W190296820 @default.
- W2134536161 cites W1906647772 @default.
- W2134536161 cites W1965375035 @default.
- W2134536161 cites W1967124917 @default.
- W2134536161 cites W1967467568 @default.
- W2134536161 cites W1969923830 @default.
- W2134536161 cites W1974824620 @default.
- W2134536161 cites W1976765213 @default.
- W2134536161 cites W1982213737 @default.
- W2134536161 cites W1982546060 @default.
- W2134536161 cites W1983612778 @default.
- W2134536161 cites W1987133729 @default.
- W2134536161 cites W1992510208 @default.
- W2134536161 cites W199516120 @default.
- W2134536161 cites W1995517904 @default.
- W2134536161 cites W1995932908 @default.
- W2134536161 cites W2000301831 @default.
- W2134536161 cites W2001630759 @default.
- W2134536161 cites W2003923106 @default.
- W2134536161 cites W2005464779 @default.
- W2134536161 cites W2010156318 @default.
- W2134536161 cites W2011722739 @default.
- W2134536161 cites W2012604762 @default.
- W2134536161 cites W2017955228 @default.
- W2134536161 cites W2019806947 @default.
- W2134536161 cites W2021065306 @default.
- W2134536161 cites W2026223669 @default.
- W2134536161 cites W2035211879 @default.
- W2134536161 cites W2038818733 @default.
- W2134536161 cites W2040032861 @default.
- W2134536161 cites W2040926299 @default.
- W2134536161 cites W2043017862 @default.
- W2134536161 cites W2055429591 @default.
- W2134536161 cites W2058575876 @default.
- W2134536161 cites W2059052465 @default.
- W2134536161 cites W2060891467 @default.
- W2134536161 cites W2069693576 @default.
- W2134536161 cites W2069786094 @default.
- W2134536161 cites W207563015 @default.
- W2134536161 cites W2080299952 @default.
- W2134536161 cites W2081185151 @default.
- W2134536161 cites W2084224210 @default.
- W2134536161 cites W2092100121 @default.
- W2134536161 cites W2093758335 @default.
- W2134536161 cites W2095106591 @default.
- W2134536161 cites W2097431653 @default.
- W2134536161 cites W2101561087 @default.
- W2134536161 cites W2103398208 @default.
- W2134536161 cites W2103771488 @default.
- W2134536161 cites W2107789427 @default.
- W2134536161 cites W2116972703 @default.
- W2134536161 cites W2118158295 @default.
- W2134536161 cites W2128814992 @default.
- W2134536161 cites W2132309800 @default.
- W2134536161 cites W2138980714 @default.
- W2134536161 cites W2142663972 @default.
- W2134536161 cites W2143531841 @default.
- W2134536161 cites W2146974608 @default.
- W2134536161 cites W2150650800 @default.
- W2134536161 cites W2153457817 @default.
- W2134536161 cites W2156655196 @default.
- W2134536161 cites W2157350771 @default.
- W2134536161 cites W2161007761 @default.
- W2134536161 cites W2161623567 @default.
- W2134536161 cites W2164046385 @default.
- W2134536161 cites W2167045574 @default.
- W2134536161 cites W2263191133 @default.
- W2134536161 cites W2287074214 @default.
- W2134536161 cites W2305127727 @default.
- W2134536161 cites W339601887 @default.
- W2134536161 cites W3509140 @default.
- W2134536161 cites W74607343 @default.
- W2134536161 cites W968930547 @default.
- W2134536161 doi "https://doi.org/10.1111/bjh.12758" @default.
- W2134536161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24499183" @default.
- W2134536161 hasPublicationYear "2014" @default.
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