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• W2134552034 abstract "The antimicrobial natural product chuangxinmycin has been found to be a potent and selective inhibitor of bacterial tryptophanyl tRNA synthetase (WRS). A number of analogues have been synthesised. The interaction with WRS appears to be highly constrained, as only sterically smaller analogues afforded significant inhibition. The only analogue to show inhibition comparable to chuangxinmycin also had antibacterial activity. WRS inhibition may contribute to the antibacterial action of chuangxinmycin." @default.
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• W2134552034 date "2002-11-01" @default.
• W2134552034 modified "2023-09-26" @default.
• W2134552034 title "The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase" @default.
• W2134552034 cites W1976375282 @default.
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• W2134552034 doi "https://doi.org/10.1016/s0960-894x(02)00604-2" @default.
• W2134552034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12372526" @default.
• W2134552034 hasPublicationYear "2002" @default.
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