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- W2134565601 abstract "The purpose of this study was to examine the relationship between mood states and β-adrenergic receptor function in a normal population. We also examined if sympathetic nervous system activity is related to mood states or β-adrenergic receptor function. Sixty-two participants aged 25–50 years were enrolled in this study. Mood states were assessed using the Profile of Mood States (POMS). β-adrenergic receptor function was determined using the chronotropic 25 dose isoproterenol infusion test. Level of sympathetic nervous system activity was estimated from 24-hr urine norepinephrine excretion. Higher tension-anxiety, depression-dejection, and anger-hostility were related to decreased β-adrenergic receptor sensitivity (i.e., higher chronotropic 25 dose values), but tension-anxiety was the only remaining independent predictor of β-adrenergic receptor function after controlling for age, gender, ethnicity, and body mass index (BMI). Urinary norepinephrine excretion was unrelated to either mood states or β-adrenergic receptor function. These findings replicate previous reports that anxiety is related to decreased (i.e., desensitized) β-adrenergic receptor sensitivity, even after controlling for age, gender, ethnicity, and body mass index. Depression and Anxiety 0:1–6, 2007. © 2007 Wiley-Liss, Inc." @default.
- W2134565601 created "2016-06-24" @default.
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- W2134565601 date "2008-07-01" @default.
- W2134565601 modified "2023-09-23" @default.
- W2134565601 title "Mood states, sympathetic activity, and in vivo β-adrenergic receptor function in a normal population" @default.
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- W2134565601 doi "https://doi.org/10.1002/da.20338" @default.
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