FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134573022> ?p ?o ?g. }

• W2134573022 endingPage "892" @default.
• W2134573022 startingPage "885" @default.
• W2134573022 abstract "While the usage of Centella asiatica (CA) is on the increase worldwide, evidence demonstrating its protective efficacy against neurotoxicants is scarce. Hence the present study aimed to understand the neuroprotective efficacy of a standardized aqueous extract of CA against 3-nitropropionic-acid(3-NPA)-induced oxidative stress in the brain of prepubertal mice. We assessed the degree of oxidative stress in cytoplasm of brain regions of male mice (4 wk- old) given CA prophylaxis (5 mg/kg bw) for 10 days followed by 3-NPA administration (i.p.75 mg/kg bw) on the last 2 days. The neurotoxicant elicited marked oxidative stress in the brain of untreated mice as evident by enhanced malondialdehyde levels, reactive oxygen species (ROS) generation, hydroperoxides and protein carbonyls (a measure of protein oxidation) in striatum and other regions (cortex, cerebellum and hippocampus), while CA prophylaxis completely ameliorated the 3-NPA- induced oxidative stress. Depletion of glutathione (GSH) levels, total thiols, perturbations in antioxidant enzymes and cholinergic enzymes in brain discernible among 3-NPA-treated mice were predominantly restored to normalcy with CA prophylaxis. It is hypothesized that the prophylactic protection offered by CA extract against neurotoxicant exposure may be largely due to its ability to enhance GSH, thiols and antioxidant defenses in the brain of prepubertal mice. Copyright © 2009 John Wiley & Sons, Ltd." @default.
• W2134573022 created "2016-06-24" @default.
• W2134573022 creator A5029059937 @default.
• W2134573022 creator A5046737585 @default.
• W2134573022 creator A5078831541 @default.
• W2134573022 date "2009-11-26" @default.
• W2134573022 modified "2023-10-13" @default.
• W2134573022 title "Prophylaxis with<i>Centella asiatica</i>confers protection to prepubertal mice against 3-nitropropionic-acid-induced oxidative stress in brain" @default.
• W2134573022 cites W1523119366 @default.
• W2134573022 cites W1546592314 @default.
• W2134573022 cites W1563847798 @default.
• W2134573022 cites W1567614586 @default.
• W2134573022 cites W1775749144 @default.
• W2134573022 cites W1846128798 @default.
• W2134573022 cites W191793640 @default.
• W2134573022 cites W1940436875 @default.
• W2134573022 cites W1967487244 @default.
• W2134573022 cites W1971048984 @default.
• W2134573022 cites W1972296376 @default.
• W2134573022 cites W1983310681 @default.
• W2134573022 cites W1999539774 @default.
• W2134573022 cites W2006370393 @default.
• W2134573022 cites W2007658546 @default.
• W2134573022 cites W2009278947 @default.
• W2134573022 cites W2012964177 @default.
• W2134573022 cites W2021784041 @default.
• W2134573022 cites W2035449153 @default.
• W2134573022 cites W2037025679 @default.
• W2134573022 cites W2042910195 @default.
• W2134573022 cites W2058881098 @default.
• W2134573022 cites W2072985414 @default.
• W2134573022 cites W2080326524 @default.
• W2134573022 cites W2082103231 @default.
• W2134573022 cites W2106828037 @default.
• W2134573022 cites W2125933976 @default.
• W2134573022 cites W2140237162 @default.
• W2134573022 cites W2148117496 @default.
• W2134573022 cites W2150387129 @default.
• W2134573022 doi "https://doi.org/10.1002/ptr.3042" @default.
• W2134573022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19943239" @default.
• W2134573022 hasPublicationYear "2009" @default.
• W2134573022 type Work @default.
• W2134573022 sameAs 2134573022 @default.
• W2134573022 citedByCount "23" @default.
• W2134573022 countsByYear W21345730222012 @default.
• W2134573022 countsByYear W21345730222013 @default.
• W2134573022 countsByYear W21345730222016 @default.
• W2134573022 countsByYear W21345730222017 @default.
• W2134573022 countsByYear W21345730222018 @default.
• W2134573022 countsByYear W21345730222020 @default.
• W2134573022 countsByYear W21345730222021 @default.
• W2134573022 countsByYear W21345730222023 @default.
• W2134573022 crossrefType "journal-article" @default.
• W2134573022 hasAuthorship W2134573022A5029059937 @default.
• W2134573022 hasAuthorship W2134573022A5046737585 @default.
• W2134573022 hasAuthorship W2134573022A5078831541 @default.
• W2134573022 hasConcept C126322002 @default.
• W2134573022 hasConcept C134018914 @default.
• W2134573022 hasConcept C181199279 @default.
• W2134573022 hasConcept C185592680 @default.
• W2134573022 hasConcept C25498285 @default.
• W2134573022 hasConcept C2776151105 @default.
• W2134573022 hasConcept C2778004101 @default.
• W2134573022 hasConcept C2778401633 @default.
• W2134573022 hasConcept C2779077069 @default.
• W2134573022 hasConcept C2780062018 @default.
• W2134573022 hasConcept C2781161787 @default.
• W2134573022 hasConcept C48349386 @default.
• W2134573022 hasConcept C513476851 @default.
• W2134573022 hasConcept C538909803 @default.
• W2134573022 hasConcept C55493867 @default.
• W2134573022 hasConcept C556039675 @default.
• W2134573022 hasConcept C71924100 @default.
• W2134573022 hasConcept C98274493 @default.
• W2134573022 hasConceptScore W2134573022C126322002 @default.
• W2134573022 hasConceptScore W2134573022C134018914 @default.
• W2134573022 hasConceptScore W2134573022C181199279 @default.
• W2134573022 hasConceptScore W2134573022C185592680 @default.
• W2134573022 hasConceptScore W2134573022C25498285 @default.
• W2134573022 hasConceptScore W2134573022C2776151105 @default.
• W2134573022 hasConceptScore W2134573022C2778004101 @default.
• W2134573022 hasConceptScore W2134573022C2778401633 @default.
• W2134573022 hasConceptScore W2134573022C2779077069 @default.
• W2134573022 hasConceptScore W2134573022C2780062018 @default.
• W2134573022 hasConceptScore W2134573022C2781161787 @default.
• W2134573022 hasConceptScore W2134573022C48349386 @default.
• W2134573022 hasConceptScore W2134573022C513476851 @default.
• W2134573022 hasConceptScore W2134573022C538909803 @default.
• W2134573022 hasConceptScore W2134573022C55493867 @default.
• W2134573022 hasConceptScore W2134573022C556039675 @default.
• W2134573022 hasConceptScore W2134573022C71924100 @default.
• W2134573022 hasConceptScore W2134573022C98274493 @default.
• W2134573022 hasIssue "6" @default.
• W2134573022 hasLocation W21345730221 @default.
• W2134573022 hasLocation W21345730222 @default.
• W2134573022 hasOpenAccess W2134573022 @default.
• W2134573022 hasPrimaryLocation W21345730221 @default.
• W2134573022 hasRelatedWork W1976505302 @default.

• next