FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134580924> ?p ?o ?g. }

• W2134580924 endingPage "1172" @default.
• W2134580924 startingPage "1163" @default.
• W2134580924 abstract "ObjectiveTo develop a mouse model for the study of the pathophysiologic mechanism and treatment of human bone marrow (BM) failure.Materials and methodsUnmanipulated B6D2F1 or CByB6F1 hybrid mice were infused with 10–40 × 106 lymph node (LN) cells from their C57BL/6 (B6) parent. Pancytopenia was monitored by cell counting, while marrow damage was assessed by histological staining. Destruction of BM hematopoietic progenitor/stem cells was measured by colony formation in vitro and irradiation protection in vivo. Serum interferon-γ (IFN-γ) concentration was measured by enzyme-linked immunosorbent assay. BM T cell Vβ and Fas expressions were analyzed by flow cytometry. Treatment effects of immunosupressive agents cyclosporine, antithymocyte globulin (ATG), anti-IFN-γ, and anti-tumor necrosis factor-α (anti-TNF-α) were tested.ResultsInfusion of 30–40 × 106B6 LN cells led to rapid development of severe pancytopenia, BM hypoplasia, and death. Affected mice had drastically reduced hematopoietic progenitor and stem cells. BM of affected mice showed lymphocyte infiltration, oligoclonal T cell expansion, and upregulated Fas expression. Serum IFN-γ concentration increased two- to three-fold. Timed administration of cyclosporine or ATG abrogated pancytopenia. Treatment with anti-IFN-γ antibody reliably rescued mice, and treatment with anti-TNF-α antibody extended animal survival significantly.ConclusionThis mouse model indicates that activated lymphocytes and type I cytokines play important roles in marrow destruction in lymphocyte infusion-induced BM failure. To develop a mouse model for the study of the pathophysiologic mechanism and treatment of human bone marrow (BM) failure. Unmanipulated B6D2F1 or CByB6F1 hybrid mice were infused with 10–40 × 106 lymph node (LN) cells from their C57BL/6 (B6) parent. Pancytopenia was monitored by cell counting, while marrow damage was assessed by histological staining. Destruction of BM hematopoietic progenitor/stem cells was measured by colony formation in vitro and irradiation protection in vivo. Serum interferon-γ (IFN-γ) concentration was measured by enzyme-linked immunosorbent assay. BM T cell Vβ and Fas expressions were analyzed by flow cytometry. Treatment effects of immunosupressive agents cyclosporine, antithymocyte globulin (ATG), anti-IFN-γ, and anti-tumor necrosis factor-α (anti-TNF-α) were tested. Infusion of 30–40 × 106B6 LN cells led to rapid development of severe pancytopenia, BM hypoplasia, and death. Affected mice had drastically reduced hematopoietic progenitor and stem cells. BM of affected mice showed lymphocyte infiltration, oligoclonal T cell expansion, and upregulated Fas expression. Serum IFN-γ concentration increased two- to three-fold. Timed administration of cyclosporine or ATG abrogated pancytopenia. Treatment with anti-IFN-γ antibody reliably rescued mice, and treatment with anti-TNF-α antibody extended animal survival significantly. This mouse model indicates that activated lymphocytes and type I cytokines play important roles in marrow destruction in lymphocyte infusion-induced BM failure." @default.
• W2134580924 created "2016-06-24" @default.
• W2134580924 creator A5018421931 @default.
• W2134580924 creator A5025452144 @default.
• W2134580924 creator A5049702839 @default.
• W2134580924 creator A5050700780 @default.
• W2134580924 creator A5072063614 @default.
• W2134580924 creator A5091715108 @default.
• W2134580924 date "2004-12-01" @default.
• W2134580924 modified "2023-10-10" @default.
• W2134580924 title "A mouse model of lymphocyte infusion-induced bone marrow failure" @default.
• W2134580924 cites W1525658012 @default.
• W2134580924 cites W1976161748 @default.
• W2134580924 cites W2005856968 @default.
• W2134580924 cites W2006865619 @default.
• W2134580924 cites W2015068315 @default.
• W2134580924 cites W2039251040 @default.
• W2134580924 cites W2041030470 @default.
• W2134580924 cites W2046637821 @default.
• W2134580924 cites W2051011787 @default.
• W2134580924 cites W2069757957 @default.
• W2134580924 cites W2109439232 @default.
• W2134580924 cites W2122118499 @default.
• W2134580924 cites W2123499187 @default.
• W2134580924 cites W2136396348 @default.
• W2134580924 cites W2271532002 @default.
• W2134580924 cites W2334062077 @default.
• W2134580924 cites W2517954470 @default.
• W2134580924 cites W43183315 @default.
• W2134580924 doi "https://doi.org/10.1016/j.exphem.2004.08.006" @default.
• W2134580924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15588941" @default.
• W2134580924 hasPublicationYear "2004" @default.
• W2134580924 type Work @default.
• W2134580924 sameAs 2134580924 @default.
• W2134580924 citedByCount "92" @default.
• W2134580924 countsByYear W21345809242012 @default.
• W2134580924 countsByYear W21345809242013 @default.
• W2134580924 countsByYear W21345809242014 @default.
• W2134580924 countsByYear W21345809242015 @default.
• W2134580924 countsByYear W21345809242016 @default.
• W2134580924 countsByYear W21345809242017 @default.
• W2134580924 countsByYear W21345809242018 @default.
• W2134580924 countsByYear W21345809242019 @default.
• W2134580924 countsByYear W21345809242020 @default.
• W2134580924 countsByYear W21345809242021 @default.
• W2134580924 countsByYear W21345809242022 @default.
• W2134580924 countsByYear W21345809242023 @default.
• W2134580924 crossrefType "journal-article" @default.
• W2134580924 hasAuthorship W2134580924A5018421931 @default.
• W2134580924 hasAuthorship W2134580924A5025452144 @default.
• W2134580924 hasAuthorship W2134580924A5049702839 @default.
• W2134580924 hasAuthorship W2134580924A5050700780 @default.
• W2134580924 hasAuthorship W2134580924A5072063614 @default.
• W2134580924 hasAuthorship W2134580924A5091715108 @default.
• W2134580924 hasBestOaLocation W21345809241 @default.
• W2134580924 hasConcept C109159458 @default.
• W2134580924 hasConcept C17991360 @default.
• W2134580924 hasConcept C201750760 @default.
• W2134580924 hasConcept C203014093 @default.
• W2134580924 hasConcept C2777761686 @default.
• W2134580924 hasConcept C2778690821 @default.
• W2134580924 hasConcept C2779382419 @default.
• W2134580924 hasConcept C2780007613 @default.
• W2134580924 hasConcept C2780849966 @default.
• W2134580924 hasConcept C28328180 @default.
• W2134580924 hasConcept C71924100 @default.
• W2134580924 hasConcept C86803240 @default.
• W2134580924 hasConcept C95444343 @default.
• W2134580924 hasConceptScore W2134580924C109159458 @default.
• W2134580924 hasConceptScore W2134580924C17991360 @default.
• W2134580924 hasConceptScore W2134580924C201750760 @default.
• W2134580924 hasConceptScore W2134580924C203014093 @default.
• W2134580924 hasConceptScore W2134580924C2777761686 @default.
• W2134580924 hasConceptScore W2134580924C2778690821 @default.
• W2134580924 hasConceptScore W2134580924C2779382419 @default.
• W2134580924 hasConceptScore W2134580924C2780007613 @default.
• W2134580924 hasConceptScore W2134580924C2780849966 @default.
• W2134580924 hasConceptScore W2134580924C28328180 @default.
• W2134580924 hasConceptScore W2134580924C71924100 @default.
• W2134580924 hasConceptScore W2134580924C86803240 @default.
• W2134580924 hasConceptScore W2134580924C95444343 @default.
• W2134580924 hasIssue "12" @default.
• W2134580924 hasLocation W21345809241 @default.
• W2134580924 hasLocation W21345809242 @default.
• W2134580924 hasOpenAccess W2134580924 @default.
• W2134580924 hasPrimaryLocation W21345809241 @default.
• W2134580924 hasRelatedWork W1978598034 @default.
• W2134580924 hasRelatedWork W1985372787 @default.
• W2134580924 hasRelatedWork W2038751426 @default.
• W2134580924 hasRelatedWork W2059732064 @default.
• W2134580924 hasRelatedWork W2060516890 @default.
• W2134580924 hasRelatedWork W2065850138 @default.
• W2134580924 hasRelatedWork W2067301395 @default.
• W2134580924 hasRelatedWork W2253242983 @default.
• W2134580924 hasRelatedWork W2784395700 @default.
• W2134580924 hasRelatedWork W2946489048 @default.
• W2134580924 hasVolume "32" @default.
• W2134580924 isParatext "false" @default.

• next