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- W2134584823 abstract "In bacteria, multiple sigmas direct RNA polymerase to distinct sets of promoters. Housekeeping sigmas direct transcription from thousands of promoters, whereas most alternative sigmas are more selective, recognizing more highly conserved promoter motifs. For sigma(32) and sigma(28), two Escherichia coli Group 3 sigmas, altering a few residues in Region 2.3, the portion of sigma implicated in promoter melting, to those universally conserved in housekeeping sigmas relaxed their stringent promoter requirements and significantly enhanced melting of suboptimal promoters. All Group 3 sigmas and the more divergent Group 4 sigmas have nonconserved amino acids at these positions and rarely transcribe >100 promoters. We suggest that the balance of melting and recognition functions of sigmas is critical to setting the stringency of promoter recognition. Divergent sigmas may generally use a nonoptimal Region 2.3 to increase promoter stringency, enabling them to mount a focused response to altered conditions." @default.
- W2134584823 created "2016-06-24" @default.
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- W2134584823 date "2009-10-15" @default.
- W2134584823 modified "2023-09-27" @default.
- W2134584823 title "Reduced capacity of alternative σs to melt promoters ensures stringent promoter recognition" @default.
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- W2134584823 doi "https://doi.org/10.1101/gad.1843709" @default.
- W2134584823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2764494" @default.
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