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• W2134604328 abstract "No AccessJournal of UrologyPediatric Urology1 Oct 2011Effect of Failed Initial Closure on Bladder Growth in Children With Bladder Exstrophy Nima Baradaran, Raimondo M. Cervellione, Ryan Orosco, Bruce J. Trock, Ranjiv I. Mathews, and John P. Gearhart Nima BaradaranNima Baradaran More articles by this author , Raimondo M. CervellioneRaimondo M. Cervellione More articles by this author , Ryan OroscoRyan Orosco More articles by this author , Bruce J. TrockBruce J. Trock More articles by this author , Ranjiv I. MathewsRanjiv I. Mathews More articles by this author , and John P. GearhartJohn P. Gearhart More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.05.067AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Failed initial bladder exstrophy closure may hinder the natural course of bladder growth compared to successful primary reconstruction. By measuring successive bladder capacities within the first 5 years of life, we compared the rate of bladder growth in children with failed vs successful initial closure. Materials and Methods: We used an approved bladder exstrophy database to identify and review retrospectively patients with classic bladder exstrophy who underwent repeat cystograms between ages 1 and 6 years. Two groups of patients were identified—those with successful neonatal closure (group 1) and those with successful reclosure after an initial failed procedure (group 2). A generalized linear mixed model was fit to evaluate the impact of treatment group and age on bladder growth. Results: We identified 48 patients in group 1 (75% male) and 62 in group 2 (71% male). Initial pelvic osteotomy was done in 60% of group 1 and 34% of group 2. Patients in group 1 had significantly larger cystographic capacity at 2, 4, 5 and 6 years after successful bladder closure compared to those in group 2 (p <0.05). The bladder tended to grow at a significantly slower rate in group 2 (9.38 cc yearly) compared to group 1 (14.76 cc yearly, p = 0.005). Conclusions: Patients with initial failed bladder exstrophy closure showed significantly smaller cystographic capacities and slower bladder growth compared to those who underwent successful neonatal bladder closure. These data clearly underscore the importance of a secure, successful primary closure. References 1 : Failed exstrophy closure: management and outcome. J Pediatr Urol2010; 6: 381. 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Google Scholar Division of Pediatric Urology, Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland© 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited bySirisreetreerux P, Lue K, Ingviya T, Friedlander D, Di Carlo H, Sponseller P and Gearhart J (2018) Failed Primary Bladder Exstrophy Closure with Osteotomy: Multivariable Analysis of a 25-Year ExperienceJournal of Urology, VOL. 197, NO. 4, (1138-1143), Online publication date: 1-Apr-2017.Gearhart J and DiCarlo H (2018) Editorial CommentJournal of Urology, VOL. 191, NO. 5, (1387-1387), Online publication date: 1-May-2014.Baradaran N, Cervellione R, Stec A and Gearhart J (2018) Delayed Primary Repair of Bladder Exstrophy: Ultimate Effect on GrowthJournal of Urology, VOL. 188, NO. 6, (2336-2342), Online publication date: 1-Dec-2012. Volume 186Issue 4October 2011Page: 1450-1454 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Keywordstreatment failurebladder exstrophyurologic surgical procedurespostoperative complicationsAcknowledgmentsDr. John Costello contributed to data gathering.MetricsAuthor Information Nima Baradaran More articles by this author Raimondo M. Cervellione More articles by this author Ryan Orosco More articles by this author Bruce J. Trock More articles by this author Ranjiv I. Mathews More articles by this author John P. Gearhart More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2134604328 title "Effect of Failed Initial Closure on Bladder Growth in Children With Bladder Exstrophy" @default.
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