FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134607537> ?p ?o ?g. }

• W2134607537 endingPage "2196" @default.
• W2134607537 startingPage "2191" @default.
• W2134607537 abstract "Addition of plasma membrane depolarizing agents, such as dinitrophenol (DNP) and azide, to cells of Saccharomyces cerevisiae under aerobic conditions, is known to cause an increase in the cAMP level within 15 s. We found that both compounds lowered the intracellular pH (measured by in vivo 32P-NMR) drastically within the same time period. Plasma membrane depolarization, however, was much slower: DNP and azide had no effect on the membrane potential during, respectively, the first 2 min and the first 10 min after addition. Apparently, the intracellular pH of yeast is much more sensitive to perturbation than the membrane potential. The effect of both compounds on the cAMP level was highly dependent on the extracellular pH: when the latter was raised, the effect disappeared completely between pH 6 and 7. A similar dependence on the extracellular pH was observed for the lowering of intracellular pH. Addition of organic acids, such as acetate and butyrate, at low pH and under aerobic conditions, also caused an immediate increase in the cAMP level and an immediate drop in the intracellular pH. These results suggest that agents such as DNP and azide do not raise the cAMP level in yeast cells because of their membrane depolarizing properties but because they lower the intracellular pH. Under anaerobic conditions, DNP, azide and organic acids were much less effective in increasing the cAMP level. Addition of a small amount of glucose, however, restored their capacity to enhance the cAMP level. This suggests that under anaerobic conditions and in the absence of glucose the ATP level is a limiting factor for cAMP synthesis." @default.
• W2134607537 created "2016-06-24" @default.
• W2134607537 creator A5019135027 @default.
• W2134607537 creator A5024803085 @default.
• W2134607537 creator A5035778660 @default.
• W2134607537 creator A5043512261 @default.
• W2134607537 creator A5044018209 @default.
• W2134607537 creator A5064264094 @default.
• W2134607537 creator A5076341898 @default.
• W2134607537 date "1987-08-01" @default.
• W2134607537 modified "2023-10-04" @default.
• W2134607537 title "Regulation of the cAMP Level in the Yeast Saccharomyces cerevisiae: Intracellular pH and the Effect of Membrane Depolarizing Compounds" @default.
• W2134607537 cites W1519612526 @default.
• W2134607537 cites W1592811188 @default.
• W2134607537 cites W1601403756 @default.
• W2134607537 cites W1790873293 @default.
• W2134607537 cites W2000875306 @default.
• W2134607537 cites W2006417687 @default.
• W2134607537 cites W2022160223 @default.
• W2134607537 cites W2032696354 @default.
• W2134607537 cites W2059611869 @default.
• W2134607537 cites W2088553977 @default.
• W2134607537 cites W2104826142 @default.
• W2134607537 cites W2135311423 @default.
• W2134607537 cites W2165869777 @default.
• W2134607537 doi "https://doi.org/10.1099/00221287-133-8-2191" @default.
• W2134607537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2832518" @default.
• W2134607537 hasPublicationYear "1987" @default.
• W2134607537 type Work @default.
• W2134607537 sameAs 2134607537 @default.
• W2134607537 citedByCount "46" @default.
• W2134607537 countsByYear W21346075372014 @default.
• W2134607537 countsByYear W21346075372018 @default.
• W2134607537 countsByYear W21346075372019 @default.
• W2134607537 countsByYear W21346075372021 @default.
• W2134607537 countsByYear W21346075372023 @default.
• W2134607537 crossrefType "journal-article" @default.
• W2134607537 hasAuthorship W2134607537A5019135027 @default.
• W2134607537 hasAuthorship W2134607537A5024803085 @default.
• W2134607537 hasAuthorship W2134607537A5035778660 @default.
• W2134607537 hasAuthorship W2134607537A5043512261 @default.
• W2134607537 hasAuthorship W2134607537A5044018209 @default.
• W2134607537 hasAuthorship W2134607537A5064264094 @default.
• W2134607537 hasAuthorship W2134607537A5076341898 @default.
• W2134607537 hasConcept C100544194 @default.
• W2134607537 hasConcept C12554922 @default.
• W2134607537 hasConcept C134897140 @default.
• W2134607537 hasConcept C178790620 @default.
• W2134607537 hasConcept C181911157 @default.
• W2134607537 hasConcept C185592680 @default.
• W2134607537 hasConcept C2776979534 @default.
• W2134607537 hasConcept C2777576037 @default.
• W2134607537 hasConcept C2779222958 @default.
• W2134607537 hasConcept C2780997848 @default.
• W2134607537 hasConcept C28406088 @default.
• W2134607537 hasConcept C4141045 @default.
• W2134607537 hasConcept C41625074 @default.
• W2134607537 hasConcept C42407357 @default.
• W2134607537 hasConcept C5140985 @default.
• W2134607537 hasConcept C55493867 @default.
• W2134607537 hasConcept C79879829 @default.
• W2134607537 hasConcept C86803240 @default.
• W2134607537 hasConceptScore W2134607537C100544194 @default.
• W2134607537 hasConceptScore W2134607537C12554922 @default.
• W2134607537 hasConceptScore W2134607537C134897140 @default.
• W2134607537 hasConceptScore W2134607537C178790620 @default.
• W2134607537 hasConceptScore W2134607537C181911157 @default.
• W2134607537 hasConceptScore W2134607537C185592680 @default.
• W2134607537 hasConceptScore W2134607537C2776979534 @default.
• W2134607537 hasConceptScore W2134607537C2777576037 @default.
• W2134607537 hasConceptScore W2134607537C2779222958 @default.
• W2134607537 hasConceptScore W2134607537C2780997848 @default.
• W2134607537 hasConceptScore W2134607537C28406088 @default.
• W2134607537 hasConceptScore W2134607537C4141045 @default.
• W2134607537 hasConceptScore W2134607537C41625074 @default.
• W2134607537 hasConceptScore W2134607537C42407357 @default.
• W2134607537 hasConceptScore W2134607537C5140985 @default.
• W2134607537 hasConceptScore W2134607537C55493867 @default.
• W2134607537 hasConceptScore W2134607537C79879829 @default.
• W2134607537 hasConceptScore W2134607537C86803240 @default.
• W2134607537 hasIssue "8" @default.
• W2134607537 hasLocation W21346075371 @default.
• W2134607537 hasLocation W21346075372 @default.
• W2134607537 hasOpenAccess W2134607537 @default.
• W2134607537 hasPrimaryLocation W21346075371 @default.
• W2134607537 hasRelatedWork W1970322189 @default.
• W2134607537 hasRelatedWork W1982973195 @default.
• W2134607537 hasRelatedWork W1986781281 @default.
• W2134607537 hasRelatedWork W2040558153 @default.
• W2134607537 hasRelatedWork W2041771357 @default.
• W2134607537 hasRelatedWork W2068406497 @default.
• W2134607537 hasRelatedWork W2068611646 @default.
• W2134607537 hasRelatedWork W2097710660 @default.
• W2134607537 hasRelatedWork W2263521778 @default.
• W2134607537 hasRelatedWork W2405411609 @default.
• W2134607537 hasVolume "133" @default.
• W2134607537 isParatext "false" @default.
• W2134607537 isRetracted "false" @default.

• next