FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134608544> ?p ?o ?g. }

• W2134608544 endingPage "119" @default.
• W2134608544 startingPage "113" @default.
• W2134608544 abstract "Paclitaxel is one of the most extensively used anticancer agents, however, its use is often limited by severe hypersensitivity reactions, including respiratory distress, bronchospasm, and hypotension, which can occur despite premedication with dexamethasone and histamine H1 and H2 antagonists. The present study was designed to determine the mechanisms of paclitaxel hypersensitivity. In rats, paclitaxel (15 mg/kg, intravenously) caused a marked increase in pulmonary vascular permeability and edema. PaO2 decreased, whereas PaCO2 increased, transiently after paclitaxel injection. The paclitaxel-induced pulmonary vascular hyperpermeability was blocked by dexamethasone but not by histamine H1 or H2 antagonists. Paclitaxel increased the vascular permeability in lungs of mast cell-deficient rats Ws/Ws(-/-) to almost the similar extent as that elicited in wild-type rats. On the other hand, the paclitaxel-induced pulmonary vascular hyperpermeability was reversed by sensory denervation with capsaicin or pretreatment with LY303870 and SR48968, NK1 and NK2 antagonists, respectively. Consistent with these findings, a marked elevation of sensory neuropeptides such as substance P, neurokinin A, and calcitonin gene-related peptide was observed in rat bronchoalveolar lavage fluid after paclitaxel injection. These findings suggest that sensory nerves rather than mast cells are implicated in the etiology of paclitaxel hypersensitivity." @default.
• W2134608544 created "2016-06-24" @default.
• W2134608544 creator A5013232618 @default.
• W2134608544 creator A5023687497 @default.
• W2134608544 creator A5034349158 @default.
• W2134608544 creator A5061089146 @default.
• W2134608544 creator A5066806706 @default.
• W2134608544 creator A5076599128 @default.
• W2134608544 creator A5083675660 @default.
• W2134608544 creator A5089532441 @default.
• W2134608544 date "2004-01-01" @default.
• W2134608544 modified "2023-10-18" @default.
• W2134608544 title "Role of Sensory Nerve Peptides Rather than Mast Cell Histamine in Paclitaxel Hypersensitivity" @default.
• W2134608544 cites W131371615 @default.
• W2134608544 cites W1933132098 @default.
• W2134608544 cites W1935541780 @default.
• W2134608544 cites W1964403533 @default.
• W2134608544 cites W1969830749 @default.
• W2134608544 cites W1971863993 @default.
• W2134608544 cites W1983313893 @default.
• W2134608544 cites W2013524808 @default.
• W2134608544 cites W2014014324 @default.
• W2134608544 cites W2016333200 @default.
• W2134608544 cites W2041547582 @default.
• W2134608544 cites W2060920691 @default.
• W2134608544 cites W2064054202 @default.
• W2134608544 cites W2067149976 @default.
• W2134608544 cites W2068155648 @default.
• W2134608544 cites W2075312993 @default.
• W2134608544 cites W2077714000 @default.
• W2134608544 cites W2080522735 @default.
• W2134608544 cites W2087550648 @default.
• W2134608544 cites W2088287882 @default.
• W2134608544 cites W2088722918 @default.
• W2134608544 cites W2091303128 @default.
• W2134608544 cites W2091787329 @default.
• W2134608544 cites W2092635728 @default.
• W2134608544 cites W2093330266 @default.
• W2134608544 cites W2114612380 @default.
• W2134608544 cites W2148484236 @default.
• W2134608544 cites W2157157957 @default.
• W2134608544 cites W2157844977 @default.
• W2134608544 cites W2166326028 @default.
• W2134608544 cites W2184694295 @default.
• W2134608544 cites W2323856378 @default.
• W2134608544 cites W2622010354 @default.
• W2134608544 cites W4255762755 @default.
• W2134608544 doi "https://doi.org/10.1164/rccm.200307-901oc" @default.
• W2134608544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14563655" @default.
• W2134608544 hasPublicationYear "2004" @default.
• W2134608544 type Work @default.
• W2134608544 sameAs 2134608544 @default.
• W2134608544 citedByCount "30" @default.
• W2134608544 countsByYear W21346085442012 @default.
• W2134608544 countsByYear W21346085442013 @default.
• W2134608544 countsByYear W21346085442015 @default.
• W2134608544 countsByYear W21346085442016 @default.
• W2134608544 countsByYear W21346085442017 @default.
• W2134608544 countsByYear W21346085442019 @default.
• W2134608544 countsByYear W21346085442020 @default.
• W2134608544 crossrefType "journal-article" @default.
• W2134608544 hasAuthorship W2134608544A5013232618 @default.
• W2134608544 hasAuthorship W2134608544A5023687497 @default.
• W2134608544 hasAuthorship W2134608544A5034349158 @default.
• W2134608544 hasAuthorship W2134608544A5061089146 @default.
• W2134608544 hasAuthorship W2134608544A5066806706 @default.
• W2134608544 hasAuthorship W2134608544A5076599128 @default.
• W2134608544 hasAuthorship W2134608544A5083675660 @default.
• W2134608544 hasAuthorship W2134608544A5089532441 @default.
• W2134608544 hasConcept C1122143 @default.
• W2134608544 hasConcept C113045295 @default.
• W2134608544 hasConcept C118303440 @default.
• W2134608544 hasConcept C126322002 @default.
• W2134608544 hasConcept C134018914 @default.
• W2134608544 hasConcept C170493617 @default.
• W2134608544 hasConcept C203014093 @default.
• W2134608544 hasConcept C2776533618 @default.
• W2134608544 hasConcept C2776694085 @default.
• W2134608544 hasConcept C2777292972 @default.
• W2134608544 hasConcept C2779726688 @default.
• W2134608544 hasConcept C2780401358 @default.
• W2134608544 hasConcept C42219234 @default.
• W2134608544 hasConcept C71924100 @default.
• W2134608544 hasConcept C98274493 @default.
• W2134608544 hasConceptScore W2134608544C1122143 @default.
• W2134608544 hasConceptScore W2134608544C113045295 @default.
• W2134608544 hasConceptScore W2134608544C118303440 @default.
• W2134608544 hasConceptScore W2134608544C126322002 @default.
• W2134608544 hasConceptScore W2134608544C134018914 @default.
• W2134608544 hasConceptScore W2134608544C170493617 @default.
• W2134608544 hasConceptScore W2134608544C203014093 @default.
• W2134608544 hasConceptScore W2134608544C2776533618 @default.
• W2134608544 hasConceptScore W2134608544C2776694085 @default.
• W2134608544 hasConceptScore W2134608544C2777292972 @default.
• W2134608544 hasConceptScore W2134608544C2779726688 @default.
• W2134608544 hasConceptScore W2134608544C2780401358 @default.
• W2134608544 hasConceptScore W2134608544C42219234 @default.
• W2134608544 hasConceptScore W2134608544C71924100 @default.

• next