Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134612441> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2134612441 startingPage "3266" @default.
- W2134612441 abstract "The global proteome of individual bronchial biopsy material from asthma and COPD patients has not been fully ascertained. The aim was to determine if mechanisms of disease and responses to treatment can be detected in biopsies from patients with asthma and COPD, using a quantitative proteomics technology. Endobronchial biopsies, pre and post treatment, were taken from patients with asthma (n=12) and COPD (n=11), as well as non-smoking (n=3) and smoking (n=2) healthy controls. Patients were randomised to double blind treatment with either placebo or budesonide (800 μg daily for 3 months). Quantitative proteomics technology was used to identify and quantify biopsy proteins. Pathways analysis was conducted to identify global proteome differences. A total of 1937 proteins were identified from all subjects. Proteome differences in asthma and COPD and changes in response to treatment could be observed. Analysis of the global proteome of COPD revealed that the top protein network contained the function of connective tissue disorder and that metabolic pathways were most relevant. In comparison, the top network in asthma contained dermatological functions, with the pathways being more actin-based. Changes in the proteome could also be observed in response to treatment. The increased relevance of cellular biological processes and decrease of oxidative stress can be seen for both asthma and COPD. Of particular interest, hepatic fibrosis was more associated with the COPD proteome and is altered with budesonide treatment. These results show that proteome differences can be detected using quantitative proteomics technology on clinically relevant biopsies from individual patients." @default.
- W2134612441 created "2016-06-24" @default.
- W2134612441 creator A5033808053 @default.
- W2134612441 creator A5044754234 @default.
- W2134612441 creator A5050443410 @default.
- W2134612441 creator A5053328406 @default.
- W2134612441 creator A5061442217 @default.
- W2134612441 creator A5066035855 @default.
- W2134612441 creator A5070918864 @default.
- W2134612441 creator A5083899470 @default.
- W2134612441 creator A5088335974 @default.
- W2134612441 creator A5088638158 @default.
- W2134612441 creator A5090431585 @default.
- W2134612441 date "2011-09-01" @default.
- W2134612441 modified "2023-09-26" @default.
- W2134612441 title "Quantitative proteomics on bronchial biopsies from asthma and COPD: Effects of budesonide treatment" @default.
- W2134612441 hasPublicationYear "2011" @default.
- W2134612441 type Work @default.
- W2134612441 sameAs 2134612441 @default.
- W2134612441 citedByCount "0" @default.
- W2134612441 crossrefType "journal-article" @default.
- W2134612441 hasAuthorship W2134612441A5033808053 @default.
- W2134612441 hasAuthorship W2134612441A5044754234 @default.
- W2134612441 hasAuthorship W2134612441A5050443410 @default.
- W2134612441 hasAuthorship W2134612441A5053328406 @default.
- W2134612441 hasAuthorship W2134612441A5061442217 @default.
- W2134612441 hasAuthorship W2134612441A5066035855 @default.
- W2134612441 hasAuthorship W2134612441A5070918864 @default.
- W2134612441 hasAuthorship W2134612441A5083899470 @default.
- W2134612441 hasAuthorship W2134612441A5088335974 @default.
- W2134612441 hasAuthorship W2134612441A5088638158 @default.
- W2134612441 hasAuthorship W2134612441A5090431585 @default.
- W2134612441 hasConcept C104317684 @default.
- W2134612441 hasConcept C104397665 @default.
- W2134612441 hasConcept C126322002 @default.
- W2134612441 hasConcept C142724271 @default.
- W2134612441 hasConcept C204787440 @default.
- W2134612441 hasConcept C27081682 @default.
- W2134612441 hasConcept C2776042228 @default.
- W2134612441 hasConcept C2776136866 @default.
- W2134612441 hasConcept C2776780178 @default.
- W2134612441 hasConcept C2781197716 @default.
- W2134612441 hasConcept C46111723 @default.
- W2134612441 hasConcept C55493867 @default.
- W2134612441 hasConcept C60644358 @default.
- W2134612441 hasConcept C71924100 @default.
- W2134612441 hasConcept C86803240 @default.
- W2134612441 hasConceptScore W2134612441C104317684 @default.
- W2134612441 hasConceptScore W2134612441C104397665 @default.
- W2134612441 hasConceptScore W2134612441C126322002 @default.
- W2134612441 hasConceptScore W2134612441C142724271 @default.
- W2134612441 hasConceptScore W2134612441C204787440 @default.
- W2134612441 hasConceptScore W2134612441C27081682 @default.
- W2134612441 hasConceptScore W2134612441C2776042228 @default.
- W2134612441 hasConceptScore W2134612441C2776136866 @default.
- W2134612441 hasConceptScore W2134612441C2776780178 @default.
- W2134612441 hasConceptScore W2134612441C2781197716 @default.
- W2134612441 hasConceptScore W2134612441C46111723 @default.
- W2134612441 hasConceptScore W2134612441C55493867 @default.
- W2134612441 hasConceptScore W2134612441C60644358 @default.
- W2134612441 hasConceptScore W2134612441C71924100 @default.
- W2134612441 hasConceptScore W2134612441C86803240 @default.
- W2134612441 hasLocation W21346124411 @default.
- W2134612441 hasOpenAccess W2134612441 @default.
- W2134612441 hasPrimaryLocation W21346124411 @default.
- W2134612441 hasRelatedWork W1123879001 @default.
- W2134612441 hasRelatedWork W202411894 @default.
- W2134612441 hasRelatedWork W2046684143 @default.
- W2134612441 hasRelatedWork W2159788183 @default.
- W2134612441 hasRelatedWork W2251153224 @default.
- W2134612441 hasRelatedWork W2555465489 @default.
- W2134612441 hasRelatedWork W2613324667 @default.
- W2134612441 hasRelatedWork W2642487554 @default.
- W2134612441 hasRelatedWork W2811469461 @default.
- W2134612441 hasRelatedWork W2849984630 @default.
- W2134612441 hasRelatedWork W2892591768 @default.
- W2134612441 hasRelatedWork W2901402567 @default.
- W2134612441 hasRelatedWork W2906568539 @default.
- W2134612441 hasRelatedWork W2982761598 @default.
- W2134612441 hasRelatedWork W2990719990 @default.
- W2134612441 hasRelatedWork W3002373571 @default.
- W2134612441 hasRelatedWork W3095234173 @default.
- W2134612441 hasRelatedWork W3127662189 @default.
- W2134612441 hasRelatedWork W3194068824 @default.
- W2134612441 hasRelatedWork W1874073344 @default.
- W2134612441 hasVolume "38" @default.
- W2134612441 isParatext "false" @default.
- W2134612441 isRetracted "false" @default.
- W2134612441 magId "2134612441" @default.
- W2134612441 workType "article" @default.