Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134629862> ?p ?o ?g. }
- W2134629862 abstract "MicroRNA targets are often recognized through pairing between the miRNA seed region and complementary sites within target mRNAs, but not all of these canonical sites are equally effective, and both computational and in vivo UV-crosslinking approaches suggest that many mRNAs are targeted through non-canonical interactions. Here, we show that recently reported non-canonical sites do not mediate repression despite binding the miRNA, which indicates that the vast majority of functional sites are canonical. Accordingly, we developed an improved quantitative model of canonical targeting, using a compendium of experimental datasets that we pre-processed to minimize confounding biases. This model, which considers site type and another 14 features to predict the most effectively targeted mRNAs, performed significantly better than existing models and was as informative as the best high-throughput in vivo crosslinking approaches. It drives the latest version of TargetScan (v7.0; targetscan.org), thereby providing a valuable resource for placing miRNAs into gene-regulatory networks." @default.
- W2134629862 created "2016-06-24" @default.
- W2134629862 creator A5002145049 @default.
- W2134629862 creator A5053838134 @default.
- W2134629862 creator A5081544816 @default.
- W2134629862 creator A5087589263 @default.
- W2134629862 date "2015-08-12" @default.
- W2134629862 modified "2023-10-18" @default.
- W2134629862 title "Predicting effective microRNA target sites in mammalian mRNAs" @default.
- W2134629862 cites W144423133 @default.
- W2134629862 cites W1513618424 @default.
- W2134629862 cites W1546952499 @default.
- W2134629862 cites W1592870802 @default.
- W2134629862 cites W1920303762 @default.
- W2134629862 cites W1964727443 @default.
- W2134629862 cites W1973333453 @default.
- W2134629862 cites W1973614663 @default.
- W2134629862 cites W1978337436 @default.
- W2134629862 cites W1983804343 @default.
- W2134629862 cites W1984948945 @default.
- W2134629862 cites W1988163167 @default.
- W2134629862 cites W1989827688 @default.
- W2134629862 cites W1989917351 @default.
- W2134629862 cites W1990868443 @default.
- W2134629862 cites W1993799748 @default.
- W2134629862 cites W1997379339 @default.
- W2134629862 cites W1998819524 @default.
- W2134629862 cites W2001293779 @default.
- W2134629862 cites W2004791359 @default.
- W2134629862 cites W2005450635 @default.
- W2134629862 cites W2011879414 @default.
- W2134629862 cites W2011913607 @default.
- W2134629862 cites W2013310179 @default.
- W2134629862 cites W2014869583 @default.
- W2134629862 cites W2015858554 @default.
- W2134629862 cites W2020469175 @default.
- W2134629862 cites W2026570544 @default.
- W2134629862 cites W2026570758 @default.
- W2134629862 cites W2028071319 @default.
- W2134629862 cites W2029747700 @default.
- W2134629862 cites W2037691883 @default.
- W2134629862 cites W2041509376 @default.
- W2134629862 cites W2042160423 @default.
- W2134629862 cites W2042673698 @default.
- W2134629862 cites W2043828851 @default.
- W2134629862 cites W2045685910 @default.
- W2134629862 cites W2049868101 @default.
- W2134629862 cites W2050869737 @default.
- W2134629862 cites W2051126469 @default.
- W2134629862 cites W2053003053 @default.
- W2134629862 cites W2054343514 @default.
- W2134629862 cites W2059073003 @default.
- W2134629862 cites W2065566217 @default.
- W2134629862 cites W2068205681 @default.
- W2134629862 cites W2068490791 @default.
- W2134629862 cites W2070571588 @default.
- W2134629862 cites W2073458778 @default.
- W2134629862 cites W2075995228 @default.
- W2134629862 cites W2077327925 @default.
- W2134629862 cites W2078657796 @default.
- W2134629862 cites W2081098333 @default.
- W2134629862 cites W2081164083 @default.
- W2134629862 cites W2082102894 @default.
- W2134629862 cites W2083381199 @default.
- W2134629862 cites W2088930981 @default.
- W2134629862 cites W2091851394 @default.
- W2134629862 cites W2096192437 @default.
- W2134629862 cites W2096217729 @default.
- W2134629862 cites W2096465161 @default.
- W2134629862 cites W2096863518 @default.
- W2134629862 cites W2098044274 @default.
- W2134629862 cites W2098980484 @default.
- W2134629862 cites W2099662046 @default.
- W2134629862 cites W2099915768 @default.
- W2134629862 cites W2101815618 @default.
- W2134629862 cites W2102292691 @default.
- W2134629862 cites W2102619694 @default.
- W2134629862 cites W2104806799 @default.
- W2134629862 cites W2105126297 @default.
- W2134629862 cites W2105197182 @default.
- W2134629862 cites W2106608030 @default.
- W2134629862 cites W2109136664 @default.
- W2134629862 cites W2112785261 @default.
- W2134629862 cites W2114058102 @default.
- W2134629862 cites W2114104545 @default.
- W2134629862 cites W2118518377 @default.
- W2134629862 cites W2118818674 @default.
- W2134629862 cites W2118994852 @default.
- W2134629862 cites W2123716127 @default.
- W2134629862 cites W2125818518 @default.
- W2134629862 cites W2126422513 @default.
- W2134629862 cites W2128016314 @default.
- W2134629862 cites W2128241046 @default.
- W2134629862 cites W2128989640 @default.
- W2134629862 cites W2130674065 @default.
- W2134629862 cites W2132023025 @default.
- W2134629862 cites W2132354121 @default.
- W2134629862 cites W2132691262 @default.
- W2134629862 cites W2133968430 @default.
- W2134629862 cites W2140952049 @default.