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• W2134634832 endingPage "367" @default.
• W2134634832 startingPage "341" @default.
• W2134634832 abstract "Novel therapeutic agents that differentially modulate immune responses are needed to boost protective immunity against infections and neoplasms and conversely, to suppress inappropriate immune reactions responsible for allergic and autoimmune disorders and the rejection of transplanted organs. One major concept that has guided the search for such agents asserts the existence of at least two types of CD4+ helper T-cells, Th1 and Th2 cells, that differ in their pattern of cytokine production and govern different arms of the immune response. Th1 cells produce IFN-γ, IL-2 and TNF-β and are involved in cell-mediated immune responses that are beneficial in host-defence against intracellular pathogens and malignant cells, but detrimental in mediating autoimmunity. Th2 cells secrete IL-4, IL-5, IL-9, IL-10 and IL-13, which augment antibody responses, including IgE production, and protect against helminth infestations but also cause allergy and asthma. Moreover, Th1 and Th2 responses are mutually antagonistic, such that they normally exist in equilibrium and cross-regulate each other. Alterations of this equilibrium are thought to underlie the etiopathogenesis of many immune-mediated diseases. By selectively targeting either one of these two types of polarised responses, it may therefore, be possible to achieve desired therapeutic effects without broad alterations of the immune system. The various strategies proposed in the patent literature of the last three years to modulate the Th1/Th2 balance are reviewed here. These include procedures that affect the differentiation of Th1 and Th2 cells, their production of effector cytokines and the activity of these cytokines. A profusion of new molecular targets for pharmacologic development has been identified and some attempts at therapeutic manipulation of Th1 and Th2 responses in clinical trials have been encouraging, while others have been disappointing. The emerging notion that Th1 and Th2 responses are themselves controlled by another category of T-cells, called regulatory T-cells, has offered further opportunities for immunotherapeutic intervention in autoimmunity and allergy." @default.
• W2134634832 created "2016-06-24" @default.
• W2134634832 creator A5045221580 @default.
• W2134634832 date "2002-03-01" @default.
• W2134634832 modified "2023-10-11" @default.
• W2134634832 title "Modulation of Th1 and Th2 responses for immunotherapy" @default.
• W2134634832 cites W144477554 @default.
• W2134634832 cites W1480238487 @default.
• W2134634832 cites W1482523072 @default.
• W2134634832 cites W1501500713 @default.
• W2134634832 cites W1519063308 @default.
• W2134634832 cites W1522588191 @default.
• W2134634832 cites W1525912444 @default.
• W2134634832 cites W1540487906 @default.
• W2134634832 cites W1543604048 @default.
• W2134634832 cites W1552475474 @default.
• W2134634832 cites W1555985183 @default.
• W2134634832 cites W1565847282 @default.
• W2134634832 cites W1567696770 @default.
• W2134634832 cites W1568297835 @default.
• W2134634832 cites W1577379061 @default.
• W2134634832 cites W1598843567 @default.
• W2134634832 cites W1598861242 @default.
• W2134634832 cites W1599148944 @default.
• W2134634832 cites W1602000691 @default.
• W2134634832 cites W1602470456 @default.
• W2134634832 cites W1612801297 @default.
• W2134634832 cites W1655860314 @default.
• W2134634832 cites W1760777150 @default.
• W2134634832 cites W1906710068 @default.
• W2134634832 cites W1962364135 @default.
• W2134634832 cites W1963829553 @default.
• W2134634832 cites W1967261754 @default.
• W2134634832 cites W1970548110 @default.
• W2134634832 cites W1970648068 @default.
• W2134634832 cites W1972497890 @default.
• W2134634832 cites W1976008320 @default.
• W2134634832 cites W1976301049 @default.
• W2134634832 cites W1980110512 @default.
• W2134634832 cites W1983285913 @default.
• W2134634832 cites W1985299393 @default.
• W2134634832 cites W1988369300 @default.
• W2134634832 cites W1990816666 @default.
• W2134634832 cites W1991524518 @default.
• W2134634832 cites W1998074829 @default.
• W2134634832 cites W2001235948 @default.
• W2134634832 cites W2002654245 @default.
• W2134634832 cites W2003694618 @default.
• W2134634832 cites W2004381788 @default.
• W2134634832 cites W2004802770 @default.
• W2134634832 cites W2005197094 @default.
• W2134634832 cites W2009342458 @default.
• W2134634832 cites W2011754426 @default.
• W2134634832 cites W2013177587 @default.
• W2134634832 cites W2015681660 @default.
• W2134634832 cites W2017828665 @default.
• W2134634832 cites W2018173725 @default.
• W2134634832 cites W2028914095 @default.
• W2134634832 cites W2034141629 @default.
• W2134634832 cites W2036146818 @default.
• W2134634832 cites W2037398046 @default.
• W2134634832 cites W2043242742 @default.
• W2134634832 cites W2046443974 @default.
• W2134634832 cites W2050604953 @default.
• W2134634832 cites W2053777701 @default.
• W2134634832 cites W2054568222 @default.
• W2134634832 cites W2059313909 @default.
• W2134634832 cites W2062683793 @default.
• W2134634832 cites W2063001043 @default.
• W2134634832 cites W2064349299 @default.
• W2134634832 cites W2065997245 @default.
• W2134634832 cites W2069302758 @default.
• W2134634832 cites W2069981713 @default.
• W2134634832 cites W2075648009 @default.
• W2134634832 cites W2081061814 @default.
• W2134634832 cites W2084624382 @default.
• W2134634832 cites W2087905758 @default.
• W2134634832 cites W2088451184 @default.
• W2134634832 cites W2098479780 @default.
• W2134634832 cites W2099712159 @default.
• W2134634832 cites W2100233250 @default.
• W2134634832 cites W2101411328 @default.
• W2134634832 cites W2101436464 @default.
• W2134634832 cites W2102563906 @default.
• W2134634832 cites W2102689053 @default.
• W2134634832 cites W2103255085 @default.
• W2134634832 cites W2103496672 @default.
• W2134634832 cites W2103885096 @default.
• W2134634832 cites W2104378716 @default.
• W2134634832 cites W2105012236 @default.
• W2134634832 cites W2110714188 @default.
• W2134634832 cites W2111246573 @default.
• W2134634832 cites W2115279260 @default.
• W2134634832 cites W2115463296 @default.
• W2134634832 cites W2116562412 @default.
• W2134634832 cites W2118011548 @default.
• W2134634832 cites W2118526748 @default.
• W2134634832 cites W2119006296 @default.

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