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• W2134653235 endingPage "2057" @default.
• W2134653235 startingPage "2052" @default.
• W2134653235 abstract "ABSTRACT During the life cycle of hepatitis B virus (HBV), the large envelope protein (L) plays a pivotal role. Indeed, this polypeptide is essential for viral assembly and probably for the infection process. By performing mutagenesis experiments, we have previously excluded a putative involvement of the pre-S2 domain of the L protein in viral infectivity. In the present study, we have evaluated the role of the pre-S1 region in HBV infection. For this purpose, 21 mutants of the L protein were created. The entire pre-S1 domain was covered by contiguous deletions of 5 amino acids. First, after transfection into HepG2 cells, the efficient expression of both glycosylated and unglycosylated L mutant proteins was verified. The secretion rate of envelope proteins was modified positively or negatively by deletions, indicating that the pre-S1 domain contains several regulating sequences able to influence the surface protein secretion. The ability of mutant proteins to support the production of virions was then studied. Only the four C-terminal deletions, covering the 17 amino acids suspected to interact with the cytoplasmic nucleocapsids, inhibited virion release. Finally, the presence of the modified pre-S1 domain at the external side of all secreted virions was confirmed, and their infectivity was assayed on normal human hepatocytes in primary culture. Only a short sequence including amino acids 78 to 87 tolerates internal deletions without affecting viral infectivity. These results confirm the involvement of the L protein in the infection step and demonstrate that the sequence between amino acids 3 and 77 is involved in this process." @default.
• W2134653235 created "2016-06-24" @default.
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• W2134653235 date "1999-03-01" @default.
• W2134653235 modified "2023-10-11" @default.
• W2134653235 title "Infection Process of the Hepatitis B Virus Depends on the Presence of a Defined Sequence in the Pre-S1 Domain" @default.
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• W2134653235 doi "https://doi.org/10.1128/jvi.73.3.2052-2057.1999" @default.
• W2134653235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/104448" @default.
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• W2134653235 hasPublicationYear "1999" @default.
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