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• W2134667046 endingPage "52" @default.
• W2134667046 startingPage "43" @default.
• W2134667046 abstract "Purpose of review Monocytes play multiple roles in immune system functions and inflammatory diseases such as atherosclerosis. These roles are coupled to diverse trafficking and cellular migration behaviors. Here, we review recent advances in our understanding of such behaviors with emphasis on broad scale trafficking patterns and the cellular and molecular mechanisms regulating diapedesis, a central aspect of trafficking. Recent findings Monocytes consist of ‘inflammatory’ and ‘resident’ subsets, which exhibit differential functions and trafficking properties. Notably, the spleen has recently been identified as a reservoir of inflammatory monocytes, which are readily recruited to injured myocardium and possibly other tissues. Resident monocytes have been shown to undergo long-range crawling within the lumen of the microvasculature, which facilitates immune surveillance and rapid response to infection. Monocyte diapedesis has been demonstrated to utilize both para and transcellular migration routes facilitated by endothelial ‘transmigratory cups’. A significant number of new adhesion molecules and signaling pathways have recently been uncovered as functional mediators and modulators of these processes. Summary Our improving understanding of monocyte trafficking and migration mechanisms has begun to shed light on the functions of these often enigmatic cells. Continued progress in this area will be critical for elucidating roles of monocytes in disease and for developing therapeutics that target monocytes." @default.
• W2134667046 created "2016-06-24" @default.
• W2134667046 creator A5010100025 @default.
• W2134667046 creator A5090914724 @default.
• W2134667046 date "2010-01-01" @default.
• W2134667046 modified "2023-10-15" @default.
• W2134667046 title "New observations on the trafficking and diapedesis of monocytes" @default.
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