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• W2134701911 abstract "Abstract In an open-label, 6-week study, we evaluated the efficacy, safety, and tolerability of fluvastatin, the first fully synthetic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, in elderly patients with type IIA primary hypercholesterolemia. After completing a 4-week, single-blind, placebo period, 39 elderly patients (17 men and 22 women; mean age, 67 ± 4 years) whose low-density lipoprotein cholesterol (LDL-C) was greater than 160 mg/dL were treated with fluvastatin 40 mg once daily in the evening. Total cholesterol, LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglycerides were measured after placebo administration (baseline) and 3 and 6 weeks of fluvastatin treatment. Apolipoproteins B (apo B) and A1 (apo A1) were measured at baseline and after 6 weeks of treatment. Safety and tolerability were assessed by monitoring routine laboratory parameters and recording spontaneously reported adverse effects. At baseline, the mean ± SD levels of total cholesterol, LDL-C, triglycerides, HDL-C, apo B, and apo A1 were 316 ± 44, 229 ± 43, 145 ± 67, 58 ± 16, 217 ± 55, and 163 ± 24 mg/dL, respectively. After 6 weeks of treatment with fluvastatin, the levels of total cholesterol, LDL-C, and apo B decreased by 22%, 29%, and 23%, respectively ( P" @default.
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• W2134701911 date "1994-04-01" @default.
• W2134701911 modified "2023-09-23" @default.
• W2134701911 title "Efficacy and safety of fluvastatin in elderly hypercholesterolemic patients: A pilot study" @default.
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• W2134701911 doi "https://doi.org/10.1016/s0011-393x(05)80525-9" @default.
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