FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134706052> ?p ?o ?g. }

• W2134706052 endingPage "5351" @default.
• W2134706052 startingPage "5351" @default.
• W2134706052 abstract "To investigate the anti-inflammatory properties of Lacto-Wolfberry (LWB), both in vitro and using a mouse model of experimental colitis.The effects of LWB on lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) and interleukin (IL)-6 secretion were assessed in a murine macrophage cell line. in vitro assessment also included characterizing the effects of LWB on the activation of NF-E2 related 2 pathway and inhibition of tumor necrosis factor-α (TNF-α)-induced nuclear factor-κB (NF-κB) activation, utilizing reporter cell lines. Following the in vitro assessment, the anti-inflammatory efficacy of an oral intervention with LWB was tested in vivo using a preclinical model of intestinal inflammation. Multiple outcomes including body weight, intestinal histology, colonic cytokine levels and anti-oxidative measures were investigated.LWB reduced the LPS-mediated induction of ROS production [+LPS vs 1% LWB + LPS, 1590 ± 188.5 relative luminescence units (RLU) vs 389 ± 5.9 RLU, P < 0.001]. LWB was more effective than wolfberry alone in reducing LPS-induced IL-6 secretion in vitro (wolfberry vs 0.5% LWB, 15% ± 7.8% vs 64% ± 5%, P < 0.001). In addition, LWB increased reporter gene expression via the anti-oxidant response element activation (wolfberry vs LWB, 73% ± 6.9% vs 148% ± 28.3%, P < 0.001) and inhibited the TNF-α-induced activation of the NF-κB pathway (milk vs LWB, 10% ± 6.7% vs 35% ± 3.3%, P < 0.05). Furthermore, oral supplementation with LWB resulted in a reduction of macroscopic (-LWB vs +LWB, 5.39 ± 0.61 vs 3.66 ± 0.59, P = 0.0445) and histological scores (-LWB vs +LWB, 5.44 ± 0.32 vs 3.66 ± 0.59, P = 0.0087) in colitic mice. These effects were associated with a significant decrease in levels of inflammatory cytokines such as IL-1β (-LWB vs +LWB, 570 ± 245 μg/L vs 89 ± 38 μg/L, P = 0.0106), keratinocyte-derived chemokine/growth regulated protein-α (-LWB vs +LWB, 184 ± 49 μg/L vs 75 ± 20 μg/L, P = 0.0244), IL-6 (-LWB vs +LWB, 318 ± 99 μg/L vs 117 ± 18 μg/L, P = 0.0315) and other pro-inflammatory proteins such as cyclooxygenase-2 (-LWB vs +LWB, 0.95 ± 0.12 AU vs 0.36 ± 0.11 AU, P = 0.0036) and phosphorylated signal transducer and activator of transcription-3 (-LWB vs +LWB, 0.51 ± 0.15 AU vs 0.1 ± 0.04 AU, P = 0.057). Moreover, antioxidant biomarkers, including expression of gene encoding for the glutathione peroxidase, in the colon and the plasma anti-oxidant capacity were significantly increased by supplementation with LWB (-LWB vs +LWB, 1.2 ± 0.21 mmol/L vs 2.1 ± 0.19 mmol/L, P = 0.0095).These results demonstrate the anti-inflammatory properties of LWB and suggest that the underlying mechanism is at least in part due to NF-κB inhibition and improved anti-oxidative capacity." @default.
• W2134706052 created "2016-06-24" @default.
• W2134706052 creator A5007976616 @default.
• W2134706052 creator A5028007643 @default.
• W2134706052 creator A5053493848 @default.
• W2134706052 creator A5066354555 @default.
• W2134706052 creator A5068275990 @default.
• W2134706052 creator A5069587735 @default.
• W2134706052 creator A5084863714 @default.
• W2134706052 creator A5089833360 @default.
• W2134706052 date "2012-01-01" @default.
• W2134706052 modified "2023-10-02" @default.
• W2134706052 title "Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis" @default.
• W2134706052 cites W1574929990 @default.
• W2134706052 cites W1648036481 @default.
• W2134706052 cites W1736962860 @default.
• W2134706052 cites W1932727195 @default.
• W2134706052 cites W1964498676 @default.
• W2134706052 cites W1967949491 @default.
• W2134706052 cites W1971265990 @default.
• W2134706052 cites W1991340166 @default.
• W2134706052 cites W1994597071 @default.
• W2134706052 cites W2000654549 @default.
• W2134706052 cites W2006438249 @default.
• W2134706052 cites W2013586614 @default.
• W2134706052 cites W2014353113 @default.
• W2134706052 cites W2025371570 @default.
• W2134706052 cites W2033363024 @default.
• W2134706052 cites W2038225067 @default.
• W2134706052 cites W2042568646 @default.
• W2134706052 cites W2045340947 @default.
• W2134706052 cites W2046065378 @default.
• W2134706052 cites W2046161149 @default.
• W2134706052 cites W2049122315 @default.
• W2134706052 cites W2057447694 @default.
• W2134706052 cites W2073057795 @default.
• W2134706052 cites W2075836508 @default.
• W2134706052 cites W2079997408 @default.
• W2134706052 cites W2081134502 @default.
• W2134706052 cites W2085637472 @default.
• W2134706052 cites W2086930880 @default.
• W2134706052 cites W2097189677 @default.
• W2134706052 cites W2119976037 @default.
• W2134706052 cites W2124569198 @default.
• W2134706052 cites W2125594840 @default.
• W2134706052 cites W2126248794 @default.
• W2134706052 cites W2135742717 @default.
• W2134706052 cites W2158702309 @default.
• W2134706052 cites W2473547645 @default.
• W2134706052 cites W43322723 @default.
• W2134706052 doi "https://doi.org/10.3748/wjg.v18.i38.5351" @default.
• W2134706052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3471103" @default.
• W2134706052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23082051" @default.
• W2134706052 hasPublicationYear "2012" @default.
• W2134706052 type Work @default.
• W2134706052 sameAs 2134706052 @default.
• W2134706052 citedByCount "19" @default.
• W2134706052 countsByYear W21347060522015 @default.
• W2134706052 countsByYear W21347060522016 @default.
• W2134706052 countsByYear W21347060522017 @default.
• W2134706052 countsByYear W21347060522018 @default.
• W2134706052 countsByYear W21347060522019 @default.
• W2134706052 countsByYear W21347060522020 @default.
• W2134706052 countsByYear W21347060522021 @default.
• W2134706052 countsByYear W21347060522022 @default.
• W2134706052 crossrefType "journal-article" @default.
• W2134706052 hasAuthorship W2134706052A5007976616 @default.
• W2134706052 hasAuthorship W2134706052A5028007643 @default.
• W2134706052 hasAuthorship W2134706052A5053493848 @default.
• W2134706052 hasAuthorship W2134706052A5066354555 @default.
• W2134706052 hasAuthorship W2134706052A5068275990 @default.
• W2134706052 hasAuthorship W2134706052A5069587735 @default.
• W2134706052 hasAuthorship W2134706052A5084863714 @default.
• W2134706052 hasAuthorship W2134706052A5089833360 @default.
• W2134706052 hasBestOaLocation W21347060521 @default.
• W2134706052 hasConcept C150903083 @default.
• W2134706052 hasConcept C164027704 @default.
• W2134706052 hasConcept C17991360 @default.
• W2134706052 hasConcept C185592680 @default.
• W2134706052 hasConcept C203014093 @default.
• W2134706052 hasConcept C207001950 @default.
• W2134706052 hasConcept C2775862500 @default.
• W2134706052 hasConcept C2776151105 @default.
• W2134706052 hasConcept C2776914184 @default.
• W2134706052 hasConcept C2778690821 @default.
• W2134706052 hasConcept C2778754761 @default.
• W2134706052 hasConcept C48349386 @default.
• W2134706052 hasConcept C55493867 @default.
• W2134706052 hasConcept C71924100 @default.
• W2134706052 hasConcept C86803240 @default.
• W2134706052 hasConceptScore W2134706052C150903083 @default.
• W2134706052 hasConceptScore W2134706052C164027704 @default.
• W2134706052 hasConceptScore W2134706052C17991360 @default.
• W2134706052 hasConceptScore W2134706052C185592680 @default.
• W2134706052 hasConceptScore W2134706052C203014093 @default.
• W2134706052 hasConceptScore W2134706052C207001950 @default.
• W2134706052 hasConceptScore W2134706052C2775862500 @default.
• W2134706052 hasConceptScore W2134706052C2776151105 @default.

• next