FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134718567> ?p ?o ?g. }

• W2134718567 endingPage "84" @default.
• W2134718567 startingPage "69" @default.
• W2134718567 abstract "Many complications in the perioperative interval are associated with genetic susceptibilities that may be unknown in advance of surgery and anesthesia, including drug toxicity and inefficacy, thrombosis, prolonged neuromuscular blockade, organ failure and sepsis. The aims of this study were to design and validate the first genetic testing platform and panel designed for use in perioperative care, to establish allele frequencies in a target population, and to determine the number of mutant alleles per patient undergoing surgery. DESIGN/SETTING/PARTICIPANTS AND METHODS: One hundred fifty patients at Marshfield Clinic, Marshfield, Wisconsin, 100 patients at the Medical College of Wisconsin Zablocki Veteran's Administration Medical Center, Milwaukee, Wisconsin, and 200 patients at the University of Wisconsin Hospitals and Clinics, Madison, Wisconsin undergoing surgery and anesthesia were tested for 48 polymorphisms in 22 genes including ABC, BChE, ACE, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, beta2AR, TPMT, F2, F5, F7, MTHFR, TNFalpha, TNFbeta, CCR5, ApoE, HBB, MYH7, ABO and Gender (PRKY, PFKFB1). Using structure-specific cleavage of oligonucleotide probes (Invader, Third Wave Technologies, Inc., Madison, WI), 96-well plates were configured so that each well contained reagents for detection of both the wild type and mutant alleles at each locus.There were 21,600 genotypes confirmed in duplicate. After withdrawal of polymorphisms in non-pathogenic genes (i.e., the ABO blood group and gender-specific alleles), 376 of 450 patients were found to be homozygous for mutant alleles at one or more loci. Modes of two mutant homozygous loci and 10 mutant alleles in aggregate (i.e., the sum of homozygous and heterozygous mutant polymorphisms) were observed per patient.Significant genetic heterogeneity that may not be accounted for by taking a family medical history, or by obtaining routine laboratory test results, is present in most patients presenting for surgery and may be detected using a newly developed genotyping platform." @default.
• W2134718567 created "2016-06-24" @default.
• W2134718567 creator A5005363240 @default.
• W2134718567 creator A5012990779 @default.
• W2134718567 creator A5014458752 @default.
• W2134718567 creator A5019979876 @default.
• W2134718567 creator A5027817326 @default.
• W2134718567 creator A5032407699 @default.
• W2134718567 creator A5043921386 @default.
• W2134718567 creator A5046315168 @default.
• W2134718567 creator A5054181165 @default.
• W2134718567 creator A5058762605 @default.
• W2134718567 creator A5059410111 @default.
• W2134718567 creator A5060012612 @default.
• W2134718567 creator A5071709823 @default.
• W2134718567 creator A5075719973 @default.
• W2134718567 creator A5079167360 @default.
• W2134718567 creator A5085588614 @default.
• W2134718567 creator A5089252452 @default.
• W2134718567 creator A5090340558 @default.
• W2134718567 date "2009-05-27" @default.
• W2134718567 modified "2023-09-27" @default.
• W2134718567 title "Perioperative Genomic Profiles Using Structure-Specific Oligonucleotide Probes" @default.
• W2134718567 cites W1483242733 @default.
• W2134718567 cites W1494786552 @default.
• W2134718567 cites W1532521916 @default.
• W2134718567 cites W1910484136 @default.
• W2134718567 cites W1963595709 @default.
• W2134718567 cites W1964698840 @default.
• W2134718567 cites W1967207972 @default.
• W2134718567 cites W1968814844 @default.
• W2134718567 cites W1975187080 @default.
• W2134718567 cites W1979150683 @default.
• W2134718567 cites W1981981738 @default.
• W2134718567 cites W1983283139 @default.
• W2134718567 cites W1987228076 @default.
• W2134718567 cites W1987353626 @default.
• W2134718567 cites W1989956851 @default.
• W2134718567 cites W1993947411 @default.
• W2134718567 cites W1995490911 @default.
• W2134718567 cites W1998231134 @default.
• W2134718567 cites W1998664238 @default.
• W2134718567 cites W1999123251 @default.
• W2134718567 cites W2001855723 @default.
• W2134718567 cites W2010740511 @default.
• W2134718567 cites W2011296046 @default.
• W2134718567 cites W2015555489 @default.
• W2134718567 cites W2015988214 @default.
• W2134718567 cites W2016756549 @default.
• W2134718567 cites W2017028707 @default.
• W2134718567 cites W2019423256 @default.
• W2134718567 cites W2020685098 @default.
• W2134718567 cites W2022841224 @default.
• W2134718567 cites W2028765231 @default.
• W2134718567 cites W2033543737 @default.
• W2134718567 cites W2033674020 @default.
• W2134718567 cites W2036194401 @default.
• W2134718567 cites W2044247751 @default.
• W2134718567 cites W2049979007 @default.
• W2134718567 cites W2054685854 @default.
• W2134718567 cites W2058264365 @default.
• W2134718567 cites W2064028703 @default.
• W2134718567 cites W2064099934 @default.
• W2134718567 cites W2067032629 @default.
• W2134718567 cites W2069984184 @default.
• W2134718567 cites W2070938507 @default.
• W2134718567 cites W2071331336 @default.
• W2134718567 cites W2073370049 @default.
• W2134718567 cites W2075702840 @default.
• W2134718567 cites W2077625973 @default.
• W2134718567 cites W2083312733 @default.
• W2134718567 cites W2084899864 @default.
• W2134718567 cites W2085795871 @default.
• W2134718567 cites W2089192919 @default.
• W2134718567 cites W2094646867 @default.
• W2134718567 cites W2096454162 @default.
• W2134718567 cites W2096922299 @default.
• W2134718567 cites W2099937170 @default.
• W2134718567 cites W2103570183 @default.
• W2134718567 cites W2104002921 @default.
• W2134718567 cites W2109453128 @default.
• W2134718567 cites W2118342649 @default.
• W2134718567 cites W2124765731 @default.
• W2134718567 cites W2126629202 @default.
• W2134718567 cites W2126850977 @default.
• W2134718567 cites W2127849598 @default.
• W2134718567 cites W2131149153 @default.
• W2134718567 cites W2137422676 @default.
• W2134718567 cites W2141777161 @default.
• W2134718567 cites W2146469349 @default.
• W2134718567 cites W2150404158 @default.
• W2134718567 cites W2151462348 @default.
• W2134718567 cites W2157049173 @default.
• W2134718567 cites W2159376754 @default.
• W2134718567 cites W2162821252 @default.
• W2134718567 cites W2163665996 @default.
• W2134718567 cites W2169854009 @default.
• W2134718567 cites W2170483665 @default.

• next