FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134722585> ?p ?o ?g. }

• W2134722585 abstract "The placenta is an essential organ that provides nutrients and oxygen to the developing fetus and removes toxic waste products from the fetal circulation. Maintaining placental blood osmotic pressure and blood flow is crucial for viable offspring. The renin-angiotensin system (RAS) in the placenta is a key player in the regulation of maternal-fetal blood flow during pregnancy. Therefore, the aim of this study was to determine if RAS genes are differentially expressed in mid to late gestation in rat placenta.Whole placental tissue samples from pregnant Sprague Dawley rats at embryonic (E) days 14.25, 15.25, 17.25 and 20 (n = 6 for each gestational age) were used for genome-wide gene expression by microarray. RAS genes with expression differences of >2 fold were further analyzed. Quantitative Real-Time PCR (qPCR) was performed on independent samples to confirm and validate microarray data. Immunohistochemisty and Western blotting were performed on a differentially expressed novel RAS pathway gene (ANPEP).Six out of 17 genes of the RAS pathway were differentially expressed at different gestational ages. Gene expression of four genes (Angiotensin converting enzyme (Ace), angiotensin converting enzyme 2 (Ace2), membrane metalloendopeptidase (Mme) and angiotensin II receptor 1A (Agtr1a)) were significantly upregulated at E20 whereas two others (Thimet oligopeptidase 1 (Thop1) and Alanyl aminopeptidase (Anpep)) were downregulated at E20 prior to the onset of labour. These changes were confirmed by qPCR. Western blots revealed no overall differences in ANPEP protein expression in the placentae. Immunohistochemical studies, however, indicated that the localization of ANPEP differed at E17.25 and E20 as ANPEP localization in the giant trophoblast cell of the junctional zone was no longer detectable at E20.The current study investigated the expression of members of the RAS pathway in rat placentae and observed significantly altered expression of 6 RAS genes at 4 gestational ages. These findings present the need for further comprehensive investigation of RAS genes in normal and complicated pregnancies." @default.
• W2134722585 created "2016-06-24" @default.
• W2134722585 creator A5003087435 @default.
• W2134722585 creator A5038469727 @default.
• W2134722585 creator A5040464804 @default.
• W2134722585 creator A5044552554 @default.
• W2134722585 creator A5046958061 @default.
• W2134722585 creator A5047465295 @default.
• W2134722585 creator A5060812724 @default.
• W2134722585 creator A5063340856 @default.
• W2134722585 creator A5080769458 @default.
• W2134722585 date "2015-08-12" @default.
• W2134722585 modified "2023-09-23" @default.
• W2134722585 title "The rat placental renin-angiotensin system - a gestational gene expression study" @default.
• W2134722585 cites W1566483010 @default.
• W2134722585 cites W1590689942 @default.
• W2134722585 cites W1963780414 @default.
• W2134722585 cites W1965937006 @default.
• W2134722585 cites W1966003401 @default.
• W2134722585 cites W1966253593 @default.
• W2134722585 cites W1974704204 @default.
• W2134722585 cites W1974891741 @default.
• W2134722585 cites W1976101448 @default.
• W2134722585 cites W1981440693 @default.
• W2134722585 cites W1993234733 @default.
• W2134722585 cites W2002223363 @default.
• W2134722585 cites W2005821276 @default.
• W2134722585 cites W2024051176 @default.
• W2134722585 cites W2025728478 @default.
• W2134722585 cites W2029118603 @default.
• W2134722585 cites W2032044261 @default.
• W2134722585 cites W2033311273 @default.
• W2134722585 cites W2037070147 @default.
• W2134722585 cites W2043531167 @default.
• W2134722585 cites W2056807152 @default.
• W2134722585 cites W2062975073 @default.
• W2134722585 cites W2077817347 @default.
• W2134722585 cites W2082595542 @default.
• W2134722585 cites W2094899779 @default.
• W2134722585 cites W2097853358 @default.
• W2134722585 cites W2098271722 @default.
• W2134722585 cites W2102846898 @default.
• W2134722585 cites W2105518264 @default.
• W2134722585 cites W2118722015 @default.
• W2134722585 cites W2121479815 @default.
• W2134722585 cites W2125465099 @default.
• W2134722585 cites W2135404019 @default.
• W2134722585 cites W2138543166 @default.
• W2134722585 cites W2142171618 @default.
• W2134722585 cites W2149396308 @default.
• W2134722585 cites W2153523244 @default.
• W2134722585 cites W2153806800 @default.
• W2134722585 cites W2162708082 @default.
• W2134722585 cites W2164226073 @default.
• W2134722585 cites W2419463348 @default.
• W2134722585 doi "https://doi.org/10.1186/s12958-015-0088-y" @default.
• W2134722585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4532142" @default.
• W2134722585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26260700" @default.
• W2134722585 hasPublicationYear "2015" @default.
• W2134722585 type Work @default.
• W2134722585 sameAs 2134722585 @default.
• W2134722585 citedByCount "14" @default.
• W2134722585 countsByYear W21347225852016 @default.
• W2134722585 countsByYear W21347225852017 @default.
• W2134722585 countsByYear W21347225852018 @default.
• W2134722585 countsByYear W21347225852020 @default.
• W2134722585 countsByYear W21347225852021 @default.
• W2134722585 countsByYear W21347225852022 @default.
• W2134722585 countsByYear W21347225852023 @default.
• W2134722585 crossrefType "journal-article" @default.
• W2134722585 hasAuthorship W2134722585A5003087435 @default.
• W2134722585 hasAuthorship W2134722585A5038469727 @default.
• W2134722585 hasAuthorship W2134722585A5040464804 @default.
• W2134722585 hasAuthorship W2134722585A5044552554 @default.
• W2134722585 hasAuthorship W2134722585A5046958061 @default.
• W2134722585 hasAuthorship W2134722585A5047465295 @default.
• W2134722585 hasAuthorship W2134722585A5060812724 @default.
• W2134722585 hasAuthorship W2134722585A5063340856 @default.
• W2134722585 hasAuthorship W2134722585A5080769458 @default.
• W2134722585 hasBestOaLocation W21347225851 @default.
• W2134722585 hasConcept C104317684 @default.
• W2134722585 hasConcept C104849204 @default.
• W2134722585 hasConcept C112672928 @default.
• W2134722585 hasConcept C126322002 @default.
• W2134722585 hasConcept C134018914 @default.
• W2134722585 hasConcept C150194340 @default.
• W2134722585 hasConcept C16685009 @default.
• W2134722585 hasConcept C172680121 @default.
• W2134722585 hasConcept C186836561 @default.
• W2134722585 hasConcept C198710026 @default.
• W2134722585 hasConcept C27016395 @default.
• W2134722585 hasConcept C2775946041 @default.
• W2134722585 hasConcept C2776953305 @default.
• W2134722585 hasConcept C2779134260 @default.
• W2134722585 hasConcept C2779234561 @default.
• W2134722585 hasConcept C2908929049 @default.
• W2134722585 hasConcept C3008058167 @default.
• W2134722585 hasConcept C48023723 @default.
• W2134722585 hasConcept C524204448 @default.
• W2134722585 hasConcept C54355233 @default.

• next