Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134723118> ?p ?o ?g. }
- W2134723118 endingPage "48" @default.
- W2134723118 startingPage "1" @default.
- W2134723118 abstract "The application of stable isotope labelling methods to the study of biosynthetic pathways of secondary metabolites is illustrated by describing studies on the biosynthesis of polyketide and terpenoid metabolites of fungal origins. The use of doubly 13C-labelled precursors provides information on the mode of assembly, cyclisation and rearrangements of polyketide and terpenoid carbon skeletons. More detailed information on the oxidation levels of biosynthetic intermediates and oxidative and reductive modifications occurring during later stages of the pathway can be obtained by the use of precursors labelled with 13C in conjunction with 2H and 18O. These methods are illustrated with reference to studies on the mechanistic and stereochemical details of polyketide chain assembly and on compounds of mixed polyketide-terpenoid (meroterpenoid) origins. Fluorine labelled precursors can provide information on key steps as well as producing interesting analogues of the natural metabolites. Application of 15N labelling in conjunction with other isotopes, e.g. 13C and 18O, is illustrated by studies on the formation of 3-nitropropanoic acid. Recent work on the enzymes of polyketide biosynthesis also makes use of multiple stable isotope labelling to assist in the elucidation of 3D protein structure and to obtain information on the mode of action of some of these enzymes." @default.
- W2134723118 created "2016-06-24" @default.
- W2134723118 creator A5084345846 @default.
- W2134723118 date "1998-01-01" @default.
- W2134723118 modified "2023-09-27" @default.
- W2134723118 title "Application of Isotopic Methods to Secondary Metabolic Pathways" @default.
- W2134723118 cites W1965943286 @default.
- W2134723118 cites W1968202462 @default.
- W2134723118 cites W1972625961 @default.
- W2134723118 cites W1972709931 @default.
- W2134723118 cites W1973123206 @default.
- W2134723118 cites W1974911285 @default.
- W2134723118 cites W1977595302 @default.
- W2134723118 cites W1978572655 @default.
- W2134723118 cites W1979527214 @default.
- W2134723118 cites W1980686390 @default.
- W2134723118 cites W1982906994 @default.
- W2134723118 cites W1985064277 @default.
- W2134723118 cites W1987450891 @default.
- W2134723118 cites W1990522875 @default.
- W2134723118 cites W1992766552 @default.
- W2134723118 cites W1994418197 @default.
- W2134723118 cites W1994826946 @default.
- W2134723118 cites W1995757319 @default.
- W2134723118 cites W1996879416 @default.
- W2134723118 cites W1998723259 @default.
- W2134723118 cites W1998837791 @default.
- W2134723118 cites W2003587561 @default.
- W2134723118 cites W2004092766 @default.
- W2134723118 cites W2004528082 @default.
- W2134723118 cites W2005069964 @default.
- W2134723118 cites W2005198262 @default.
- W2134723118 cites W2008056955 @default.
- W2134723118 cites W2011631283 @default.
- W2134723118 cites W2011633388 @default.
- W2134723118 cites W2012266343 @default.
- W2134723118 cites W2016063174 @default.
- W2134723118 cites W2019497184 @default.
- W2134723118 cites W2020497749 @default.
- W2134723118 cites W2025175775 @default.
- W2134723118 cites W2025735066 @default.
- W2134723118 cites W2028075731 @default.
- W2134723118 cites W2029631092 @default.
- W2134723118 cites W2032606624 @default.
- W2134723118 cites W2035948221 @default.
- W2134723118 cites W2038909991 @default.
- W2134723118 cites W2044232112 @default.
- W2134723118 cites W2045194531 @default.
- W2134723118 cites W2048001781 @default.
- W2134723118 cites W2048851112 @default.
- W2134723118 cites W2049046788 @default.
- W2134723118 cites W2051095247 @default.
- W2134723118 cites W2053020100 @default.
- W2134723118 cites W2056839487 @default.
- W2134723118 cites W2062462277 @default.
- W2134723118 cites W2067877853 @default.
- W2134723118 cites W2068904968 @default.
- W2134723118 cites W2070215751 @default.
- W2134723118 cites W2071634836 @default.
- W2134723118 cites W2074424843 @default.
- W2134723118 cites W2075009831 @default.
- W2134723118 cites W2076290357 @default.
- W2134723118 cites W2077353900 @default.
- W2134723118 cites W2077641224 @default.
- W2134723118 cites W2078559849 @default.
- W2134723118 cites W2084127435 @default.
- W2134723118 cites W2085804407 @default.
- W2134723118 cites W2087222669 @default.
- W2134723118 cites W2088516622 @default.
- W2134723118 cites W2089262177 @default.
- W2134723118 cites W2091282865 @default.
- W2134723118 cites W2093159492 @default.
- W2134723118 cites W2093744716 @default.
- W2134723118 cites W2097450583 @default.
- W2134723118 cites W2118512093 @default.
- W2134723118 cites W2120686006 @default.
- W2134723118 cites W2121589536 @default.
- W2134723118 cites W2124427225 @default.
- W2134723118 cites W2139666558 @default.
- W2134723118 cites W2141747073 @default.
- W2134723118 cites W2151812659 @default.
- W2134723118 cites W2159229280 @default.
- W2134723118 cites W2165106852 @default.
- W2134723118 cites W2168709372 @default.
- W2134723118 cites W2171602608 @default.
- W2134723118 cites W2325528931 @default.
- W2134723118 cites W2333077184 @default.
- W2134723118 cites W2768365458 @default.
- W2134723118 cites W2952504726 @default.
- W2134723118 cites W4232729256 @default.
- W2134723118 cites W4252393624 @default.
- W2134723118 cites W2139700410 @default.
- W2134723118 doi "https://doi.org/10.1007/3-540-69542-7_1" @default.
- W2134723118 hasPublicationYear "1998" @default.
- W2134723118 type Work @default.
- W2134723118 sameAs 2134723118 @default.
- W2134723118 citedByCount "36" @default.
- W2134723118 countsByYear W21347231182012 @default.