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- W2134723973 abstract "The contribution of epithelial-to-mesenchymal transitions (EMT) in both developmental and pathological conditions has been widely recognized and studied. In a parallel process, governed by a similar set of signaling and transcription factors, endothelial-to-mesenchymal transitions (EndoMT) contribute to heart valve formation and the generation of cancer-associated fibroblasts. During angiogenic sprouting, endothelial cells express many of the same genes and break down basement membrane; however, they retain intercellular junctions and migrate as a connected train of cells rather than as individual cells. This has been termed a partial endothelial-to-mesenchymal transition. A key regulatory check-point determines whether cells undergo a full or a partial epithelial-to-mesenchymal transitions/endothelial-to-mesenchymal transition; however, very little is known about how this switch is controlled. Here we discuss these developmental/pathological pathways, with a particular focus on their role in vascular biology." @default.
- W2134723973 created "2016-06-24" @default.
- W2134723973 creator A5021302693 @default.
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- W2134723973 date "2015-02-01" @default.
- W2134723973 modified "2023-10-02" @default.
- W2134723973 title "A Role for Partial Endothelial–Mesenchymal Transitions in Angiogenesis?" @default.
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- W2134723973 doi "https://doi.org/10.1161/atvbaha.114.303220" @default.
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