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- W2134730633 abstract "Cancer cells cooperate with stromal cells and use their environment to promote tumor growth. Energy production depends on nutrient availability and O₂ concentration. Well-oxygenated cells are highly proliferative and reorient the glucose metabolism towards biosynthesis, whereas glutamine oxidation replenishes the TCA cycle coupled with OXPHOS-ATP production. Glucose, glutamine and alanine transformations sustain nucleotide and fatty acid synthesis. In contrast, hypoxic cells slow down their proliferation, enhance glycolysis to produce ATP and reject lactate which is recycled as fuel by normoxic cells. Thus, glucose is spared for biosynthesis and/or for hypoxic cell function. Environmental cells, such as fibroblasts and adipocytes, serve as food donors for cancer cells, which reject waste products (CO₂ , H⁺, ammoniac, polyamines…) promoting EMT, invasion, angiogenesis and proliferation. This metabolic-coupling can be considered as a form of commensalism whereby non-malignant cells support the growth of cancer cells. Understanding these cellular cooperations within tumors may be a source of inspiration to develop new anti-cancer agents." @default.
- W2134730633 created "2016-06-24" @default.
- W2134730633 creator A5016012559 @default.
- W2134730633 creator A5029902285 @default.
- W2134730633 creator A5058311487 @default.
- W2134730633 creator A5078550481 @default.
- W2134730633 creator A5082065124 @default.
- W2134730633 date "2014-08-01" @default.
- W2134730633 modified "2023-10-14" @default.
- W2134730633 title "The metabolic cooperation between cells in solid cancer tumors" @default.
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