Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134733079> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2134733079 endingPage "1447" @default.
- W2134733079 startingPage "1440" @default.
- W2134733079 abstract "We examined the antifungal activity of various synthetic triamines on several fungi. Among various triamines having a general structure H2N(CH2)aNH(CH2)bNH2 (a=2–5, b=3–8), some triamines (a=4 or 5) showed inhibitory effect on the growth of Candida albicans and C. tropicalis. Determination of the minimum inhibitory concentrations (MICs) of these triamines on C. albicans showed that triamine 4–8 (a=4, b=8) and triamine 5–8 had strong antifungal activity. Further analysis revealed that the antifungal effect of triamine 4–8 was fungistatic and the antifungal effect was diminished by the addition of spermidine, a physiological triamine, to the medium. These results suggested that triamine 4–8 is antagonistic to spermidine and the antifungal activity is due to the suppression of the action of intrinsic polyamines. On the agar medium, C. albicans formed microcolonies even in the presence of triamine 4–8 by long cultivation. We then observed the form of C. albicans using microscope and found that the cells cultivated with triamine 4–8 were round, similar to the yeast form, while most of the cells on the agar medium without triamine 4–8 were hyphal form. Subsequently, we investigated the synergistic effect of two compounds with triamine 4–8, cyclohexylamine and dl-α-difluoromethylornithine which are inhibitors of enzymes involving in the biosynthesis of physiological polyamines such as spermidine. The results showed that the antifungal activity of triamine 4–8 increased by the addition of these enzyme inhibitors." @default.
- W2134733079 created "2016-06-24" @default.
- W2134733079 creator A5004365170 @default.
- W2134733079 creator A5006672774 @default.
- W2134733079 creator A5028779042 @default.
- W2134733079 creator A5042504378 @default.
- W2134733079 creator A5048912388 @default.
- W2134733079 creator A5058822296 @default.
- W2134733079 date "2013-01-01" @default.
- W2134733079 modified "2023-10-18" @default.
- W2134733079 title "Spermidine-Analogous Triamines Suppressed the Growth of <i>Candida albicans</i>" @default.
- W2134733079 cites W2002344173 @default.
- W2134733079 cites W2004899528 @default.
- W2134733079 cites W2014489014 @default.
- W2134733079 cites W2018685698 @default.
- W2134733079 cites W2041611856 @default.
- W2134733079 cites W2077167936 @default.
- W2134733079 cites W2092504070 @default.
- W2134733079 cites W2104047392 @default.
- W2134733079 doi "https://doi.org/10.1248/bpb.b13-00148" @default.
- W2134733079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23995655" @default.
- W2134733079 hasPublicationYear "2013" @default.
- W2134733079 type Work @default.
- W2134733079 sameAs 2134733079 @default.
- W2134733079 citedByCount "1" @default.
- W2134733079 countsByYear W21347330792020 @default.
- W2134733079 crossrefType "journal-article" @default.
- W2134733079 hasAuthorship W2134733079A5004365170 @default.
- W2134733079 hasAuthorship W2134733079A5006672774 @default.
- W2134733079 hasAuthorship W2134733079A5028779042 @default.
- W2134733079 hasAuthorship W2134733079A5042504378 @default.
- W2134733079 hasAuthorship W2134733079A5048912388 @default.
- W2134733079 hasAuthorship W2134733079A5058822296 @default.
- W2134733079 hasBestOaLocation W21347330791 @default.
- W2134733079 hasConcept C145081991 @default.
- W2134733079 hasConcept C181199279 @default.
- W2134733079 hasConcept C185592680 @default.
- W2134733079 hasConcept C2776109719 @default.
- W2134733079 hasConcept C2777497464 @default.
- W2134733079 hasConcept C2778660310 @default.
- W2134733079 hasConcept C2779222958 @default.
- W2134733079 hasConcept C2779548794 @default.
- W2134733079 hasConcept C2780917455 @default.
- W2134733079 hasConcept C523546767 @default.
- W2134733079 hasConcept C54355233 @default.
- W2134733079 hasConcept C55493867 @default.
- W2134733079 hasConcept C62643968 @default.
- W2134733079 hasConcept C71240020 @default.
- W2134733079 hasConcept C86803240 @default.
- W2134733079 hasConcept C89423630 @default.
- W2134733079 hasConceptScore W2134733079C145081991 @default.
- W2134733079 hasConceptScore W2134733079C181199279 @default.
- W2134733079 hasConceptScore W2134733079C185592680 @default.
- W2134733079 hasConceptScore W2134733079C2776109719 @default.
- W2134733079 hasConceptScore W2134733079C2777497464 @default.
- W2134733079 hasConceptScore W2134733079C2778660310 @default.
- W2134733079 hasConceptScore W2134733079C2779222958 @default.
- W2134733079 hasConceptScore W2134733079C2779548794 @default.
- W2134733079 hasConceptScore W2134733079C2780917455 @default.
- W2134733079 hasConceptScore W2134733079C523546767 @default.
- W2134733079 hasConceptScore W2134733079C54355233 @default.
- W2134733079 hasConceptScore W2134733079C55493867 @default.
- W2134733079 hasConceptScore W2134733079C62643968 @default.
- W2134733079 hasConceptScore W2134733079C71240020 @default.
- W2134733079 hasConceptScore W2134733079C86803240 @default.
- W2134733079 hasConceptScore W2134733079C89423630 @default.
- W2134733079 hasIssue "9" @default.
- W2134733079 hasLocation W21347330791 @default.
- W2134733079 hasLocation W21347330792 @default.
- W2134733079 hasOpenAccess W2134733079 @default.
- W2134733079 hasPrimaryLocation W21347330791 @default.
- W2134733079 hasRelatedWork W1560715712 @default.
- W2134733079 hasRelatedWork W1801898498 @default.
- W2134733079 hasRelatedWork W1912163066 @default.
- W2134733079 hasRelatedWork W1985617832 @default.
- W2134733079 hasRelatedWork W2034541346 @default.
- W2134733079 hasRelatedWork W2474825070 @default.
- W2134733079 hasRelatedWork W2607418533 @default.
- W2134733079 hasRelatedWork W2945082719 @default.
- W2134733079 hasRelatedWork W3116480693 @default.
- W2134733079 hasRelatedWork W7163209 @default.
- W2134733079 hasVolume "36" @default.
- W2134733079 isParatext "false" @default.
- W2134733079 isRetracted "false" @default.
- W2134733079 magId "2134733079" @default.
- W2134733079 workType "article" @default.