FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134736479> ?p ?o ?g. }

• W2134736479 endingPage "523" @default.
• W2134736479 startingPage "516" @default.
• W2134736479 abstract "Purpose of review Although the genetic defect underlying achondroplasia has been known for over a decade, no effective therapies to stimulate bone growth have emerged. Here we review the recent literature and summarize the molecular mechanisms underlying disease pathology and examine their potential as therapeutic targets. Currently used preclinical models are discussed in the context of recent advances with a special focus on C-type natriuretic peptide. Recent findings Research on the mutation in Fibroblast Growth Factor Receptor 3 (FGFR3) that causes achondroplasia suggests that disease results from increased signal transduction from the mutant receptor. Thus, current therapeutic strategies have focused on reducing signals emanating from FGFR3. First-generation therapies directly targeting FGFR3, such as kinase inhibitors and neutralizing antibodies, designed for targeting FGFR3 in cancer, are still in the preclinical phase and have yet to translate into the management of achondroplasia. Counteracting signal transduction pathways downstream of FGFR3 holds promise with the discovery that administration of C-type natriuretic peptide to achondroplastic mice ameliorates their clinical phenotype. However, more research into long-term effectiveness and safety of this strategy is needed. Direct targeting of therapeutic agents to growth plate cartilage may enhance efficacy and minimize side effects of these and future therapies. Summary Current research into the pathogenesis of achondroplasia has expanded our understanding of the mechanisms of FGFR3-induced disease and has increased the number of approaches that we may use to potentially correct it. Further research is needed to validate these approaches in preclinical models of achondroplasia." @default.
• W2134736479 created "2016-06-24" @default.
• W2134736479 creator A5000642159 @default.
• W2134736479 creator A5079896240 @default.
• W2134736479 date "2010-08-01" @default.
• W2134736479 modified "2023-10-17" @default.
• W2134736479 title "Achondroplasia: pathogenesis and implications for future treatment" @default.
• W2134736479 cites W1491435711 @default.
• W2134736479 cites W1563019250 @default.
• W2134736479 cites W1570281893 @default.
• W2134736479 cites W1967485093 @default.
• W2134736479 cites W1972979483 @default.
• W2134736479 cites W1986671812 @default.
• W2134736479 cites W1988790505 @default.
• W2134736479 cites W1989073601 @default.
• W2134736479 cites W1990125854 @default.
• W2134736479 cites W1994773160 @default.
• W2134736479 cites W1995352016 @default.
• W2134736479 cites W2002093455 @default.
• W2134736479 cites W2002387722 @default.
• W2134736479 cites W2002684795 @default.
• W2134736479 cites W2005508652 @default.
• W2134736479 cites W2009561348 @default.
• W2134736479 cites W2018896819 @default.
• W2134736479 cites W2019804835 @default.
• W2134736479 cites W2036851890 @default.
• W2134736479 cites W2040325305 @default.
• W2134736479 cites W2042545863 @default.
• W2134736479 cites W2042932723 @default.
• W2134736479 cites W2047727235 @default.
• W2134736479 cites W2049903695 @default.
• W2134736479 cites W2050434322 @default.
• W2134736479 cites W2054745605 @default.
• W2134736479 cites W2055935604 @default.
• W2134736479 cites W2056983875 @default.
• W2134736479 cites W2060029591 @default.
• W2134736479 cites W2063656824 @default.
• W2134736479 cites W2067954073 @default.
• W2134736479 cites W2072303535 @default.
• W2134736479 cites W2075500765 @default.
• W2134736479 cites W2079521049 @default.
• W2134736479 cites W2093291689 @default.
• W2134736479 cites W2094033054 @default.
• W2134736479 cites W2095509444 @default.
• W2134736479 cites W2098150638 @default.
• W2134736479 cites W2101469591 @default.
• W2134736479 cites W2103440945 @default.
• W2134736479 cites W2105419881 @default.
• W2134736479 cites W2108698814 @default.
• W2134736479 cites W2112099875 @default.
• W2134736479 cites W2112882256 @default.
• W2134736479 cites W2112893967 @default.
• W2134736479 cites W2115675418 @default.
• W2134736479 cites W2119042862 @default.
• W2134736479 cites W2128725121 @default.
• W2134736479 cites W2131942504 @default.
• W2134736479 cites W2132437319 @default.
• W2134736479 cites W2134872136 @default.
• W2134736479 cites W2134962084 @default.
• W2134736479 cites W2135930613 @default.
• W2134736479 cites W2137864841 @default.
• W2134736479 cites W2142994154 @default.
• W2134736479 cites W2143895308 @default.
• W2134736479 cites W2145821846 @default.
• W2134736479 cites W2157697960 @default.
• W2134736479 cites W2158317138 @default.
• W2134736479 cites W2158411945 @default.
• W2134736479 cites W2158872919 @default.
• W2134736479 cites W2162498210 @default.
• W2134736479 cites W2169147580 @default.
• W2134736479 cites W2170273061 @default.
• W2134736479 cites W2170962175 @default.
• W2134736479 cites W4211105381 @default.
• W2134736479 doi "https://doi.org/10.1097/mop.0b013e32833b7a69" @default.
• W2134736479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20601886" @default.
• W2134736479 hasPublicationYear "2010" @default.
• W2134736479 type Work @default.
• W2134736479 sameAs 2134736479 @default.
• W2134736479 citedByCount "68" @default.
• W2134736479 countsByYear W21347364792012 @default.
• W2134736479 countsByYear W21347364792013 @default.
• W2134736479 countsByYear W21347364792014 @default.
• W2134736479 countsByYear W21347364792015 @default.
• W2134736479 countsByYear W21347364792016 @default.
• W2134736479 countsByYear W21347364792018 @default.
• W2134736479 countsByYear W21347364792019 @default.
• W2134736479 countsByYear W21347364792020 @default.
• W2134736479 countsByYear W21347364792021 @default.
• W2134736479 countsByYear W21347364792022 @default.
• W2134736479 countsByYear W21347364792023 @default.
• W2134736479 crossrefType "journal-article" @default.
• W2134736479 hasAuthorship W2134736479A5000642159 @default.
• W2134736479 hasAuthorship W2134736479A5079896240 @default.
• W2134736479 hasConcept C126322002 @default.
• W2134736479 hasConcept C141071460 @default.
• W2134736479 hasConcept C142724271 @default.
• W2134736479 hasConcept C147708747 @default.
• W2134736479 hasConcept C170493617 @default.

• next