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- W2134737504 abstract "The objective of the present study was test the anti-inflammatory efficacy of diclofenac dietilamine, applied epicutaneously at a dose rate of 0.44 mg kg� 1 , in a model of acute arthritis in horses. Four clinical end-points, as well as two biochemical markers, were used as surrogate markers of the required clinical response (analgesia, anti-inflammatory). Low diclofenac concentrations were measured in blood (Cmax 0.04±0.03 ug mL� 1 ) and synovial fluid (Cmax 0.08 ±0.08 ug mL� 1 ) from the first to the last sampling time. The statistical comparison of the clinical end-points and biochemical markers between placebo and dicilofenac treated group indicated a lack of pharmacological effect of this compound after epicutaneous administration." @default.
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- W2134737504 date "2006-01-01" @default.
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- W2134737504 title "Inefficacy of Topical Diclofenac in Arthritic Horses" @default.
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- W2134737504 doi "https://doi.org/10.3844/ajavsp.2006.8.12" @default.
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