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• W2134737903 abstract "The role of microglia, the brain-resident macrophages, in glioma biology is still a matter of debate. Clinical observations and in vitro studies in the mouse model indicate that microglia and macrophages that infiltrate the brain tumor tissue in high numbers play a tumor-supportive role. Here, we provide evidence that human microglia isolated from brain tumors indeed support tumor cell growth, migration, and invasion. However, after stimulation with the Toll-like receptor 3 agonist poly (I:C), microglia secrete factors that exerted toxic and suppressive effects on different glioblastoma cell lines, as assessed in cytotoxicity, migration, and tumor cell spheroid invasion assays. Remarkably, these effects were tumor-specific because the microglial factors impaired neither growth nor viability of astrocytes and neurons. Culture supernatants of tumor cells inhibited the poly (I:C) induction of this microglial M1-like, oncotoxic profile. Microglia stimulation before coculture with tumor cells circumvented the tumor-mediated suppression, as demonstrated by the ability to kill and phagocytose glioma cells. Our results show, for the first time to our knowledge, that human microglia exert tumor-supporting functions that are overridden by tumor-suppressing activities gained after poly (I:C) stimulation." @default.
• W2134737903 created "2016-06-24" @default.
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• W2134737903 date "2011-10-20" @default.
• W2134737903 modified "2023-10-17" @default.
• W2134737903 title "Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation" @default.
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• W2134737903 doi "https://doi.org/10.1093/neuonc/nor182" @default.
• W2134737903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3245995" @default.
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