FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134741034> ?p ?o ?g. }

• W2134741034 endingPage "626" @default.
• W2134741034 startingPage "621" @default.
• W2134741034 abstract "Both as a component of metabolic syndrome and as an independent entity, hypertension poses a continued challenge with regard to its diagnosis, pathogenesis, and treatment. Previous studies have documented connections between hypertension and indicators of lipid metabolism. Novel technologies, such as plasma lipidomic profiling, promise a better understanding of disorders in which there is a derangement of the lipid metabolism. However, association of plasma lipidomic profiles with hypertension in a high-risk population, such as Mexican Americans, has not been evaluated before. Using the rich data and sample resource from the ongoing San Antonio Family Heart Study, we conducted plasma lipidomic profiling by combining high-performance liquid chromatography with tandem mass spectroscopy to characterize 319 lipid species in 1192 individuals from 42 large and extended Mexican American families. Robust statistical analyses using polygenic regression models, liability threshold models, and bivariate trait analyses implemented in the SOLAR software were conducted after accounting for obesity, insulin resistance, and relative abundance of various lipoprotein fractions. Diacylglycerols, in general, and the DG 16:0/22:5 and DG 16:0/22:6 lipid species, in particular, were significantly associated with systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), as well as liability of incident hypertension measured during 7140.17 person-years of follow-up. Four lipid species, including the DG 16:0/22:5 and DG 16:0/22:6 species, showed significant genetic correlations with the liability of hypertension in bivariate trait analyses. Our results demonstrate the value of plasma lipidomic profiling in the context of hypertension and identify disturbance of diacylglycerol metabolism as an independent biomarker of hypertension." @default.
• W2134741034 created "2016-06-24" @default.
• W2134741034 creator A5001935511 @default.
• W2134741034 creator A5004538115 @default.
• W2134741034 creator A5010053509 @default.
• W2134741034 creator A5010188514 @default.
• W2134741034 creator A5011126513 @default.
• W2134741034 creator A5015824852 @default.
• W2134741034 creator A5017431021 @default.
• W2134741034 creator A5018883009 @default.
• W2134741034 creator A5020806539 @default.
• W2134741034 creator A5039056655 @default.
• W2134741034 creator A5073224358 @default.
• W2134741034 creator A5075618748 @default.
• W2134741034 creator A5079020015 @default.
• W2134741034 creator A5082680532 @default.
• W2134741034 creator A5088365248 @default.
• W2134741034 date "2013-09-01" @default.
• W2134741034 modified "2023-10-11" @default.
• W2134741034 title "Plasma Lipidomic Profile Signature of Hypertension in Mexican American Families" @default.
• W2134741034 cites W1483087113 @default.
• W2134741034 cites W1569454591 @default.
• W2134741034 cites W1965555277 @default.
• W2134741034 cites W1971922912 @default.
• W2134741034 cites W1977459863 @default.
• W2134741034 cites W1987110992 @default.
• W2134741034 cites W1988802259 @default.
• W2134741034 cites W1990111410 @default.
• W2134741034 cites W2000050828 @default.
• W2134741034 cites W2000944657 @default.
• W2134741034 cites W2004804839 @default.
• W2134741034 cites W2004915770 @default.
• W2134741034 cites W2005052233 @default.
• W2134741034 cites W2011076773 @default.
• W2134741034 cites W2016785044 @default.
• W2134741034 cites W2018300286 @default.
• W2134741034 cites W2031077897 @default.
• W2134741034 cites W2033841045 @default.
• W2134741034 cites W2041911757 @default.
• W2134741034 cites W2053770852 @default.
• W2134741034 cites W2054033174 @default.
• W2134741034 cites W2054813348 @default.
• W2134741034 cites W2057826903 @default.
• W2134741034 cites W2067191792 @default.
• W2134741034 cites W2075420402 @default.
• W2134741034 cites W2078562982 @default.
• W2134741034 cites W2084626860 @default.
• W2134741034 cites W2090721334 @default.
• W2134741034 cites W2095592205 @default.
• W2134741034 cites W2108844725 @default.
• W2134741034 cites W2115335486 @default.
• W2134741034 cites W2116691218 @default.
• W2134741034 cites W2134204898 @default.
• W2134741034 cites W2136565792 @default.
• W2134741034 cites W2137973437 @default.
• W2134741034 cites W2148473209 @default.
• W2134741034 cites W2149290189 @default.
• W2134741034 cites W2152138503 @default.
• W2134741034 cites W2153150225 @default.
• W2134741034 cites W21612260 @default.
• W2134741034 cites W2166628970 @default.
• W2134741034 cites W2168481657 @default.
• W2134741034 cites W2172095464 @default.
• W2134741034 cites W2315978649 @default.
• W2134741034 cites W2331941806 @default.
• W2134741034 doi "https://doi.org/10.1161/hypertensionaha.113.01396" @default.
• W2134741034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3789127" @default.
• W2134741034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23798346" @default.
• W2134741034 hasPublicationYear "2013" @default.
• W2134741034 type Work @default.
• W2134741034 sameAs 2134741034 @default.
• W2134741034 citedByCount "81" @default.
• W2134741034 countsByYear W21347410342013 @default.
• W2134741034 countsByYear W21347410342014 @default.
• W2134741034 countsByYear W21347410342015 @default.
• W2134741034 countsByYear W21347410342016 @default.
• W2134741034 countsByYear W21347410342017 @default.
• W2134741034 countsByYear W21347410342018 @default.
• W2134741034 countsByYear W21347410342019 @default.
• W2134741034 countsByYear W21347410342020 @default.
• W2134741034 countsByYear W21347410342021 @default.
• W2134741034 countsByYear W21347410342022 @default.
• W2134741034 countsByYear W21347410342023 @default.
• W2134741034 crossrefType "journal-article" @default.
• W2134741034 hasAuthorship W2134741034A5001935511 @default.
• W2134741034 hasAuthorship W2134741034A5004538115 @default.
• W2134741034 hasAuthorship W2134741034A5010053509 @default.
• W2134741034 hasAuthorship W2134741034A5010188514 @default.
• W2134741034 hasAuthorship W2134741034A5011126513 @default.
• W2134741034 hasAuthorship W2134741034A5015824852 @default.
• W2134741034 hasAuthorship W2134741034A5017431021 @default.
• W2134741034 hasAuthorship W2134741034A5018883009 @default.
• W2134741034 hasAuthorship W2134741034A5020806539 @default.
• W2134741034 hasAuthorship W2134741034A5039056655 @default.
• W2134741034 hasAuthorship W2134741034A5073224358 @default.
• W2134741034 hasAuthorship W2134741034A5075618748 @default.
• W2134741034 hasAuthorship W2134741034A5079020015 @default.
• W2134741034 hasAuthorship W2134741034A5082680532 @default.

• next