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- W2134744504 abstract "Peripheral muscle dysfunction in COPD patients has been related to a muscle/fiber atrophy and oxidative metabolism reduction, which mimicks a severe disuse. Thus, we investigated the structure and mitochondrial function in skeletal muscle biopsies from patients with COPD and sedentary healthy subjects (SHS). 24 stage I-III (according to the GOLD classification) COPD patients and 21 age-matched SHS ( COPD patient and PA level-matched SHS (activity counts/day: 133±70 vs 135±48; p=0,9), had the same muscle mass and fiber cross-sectional areas. However, there was a reduction of the quadriceps endurance and of the type I fiber proportion (35% [28-49] vs 41% [38-53]; p This study showed an early impairment of the muscle oxidative metabolism (type I fibers and mitochondrial efficiency), unexplained by the PA reduction in COPD patients and suggest that the oxidative phosphorylation alteration (OXPHOS pathway) occurs in the PHOS part, i.e. the ATP synthesis rate." @default.
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- W2134744504 date "2011-09-01" @default.
- W2134744504 modified "2023-10-18" @default.
- W2134744504 title "Early peripheral muscle structural and metabolic impairment in chronic obstructive pulmonary disease (COPD) patients cannot be considered as a consequence of sedentarity" @default.
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