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• W2134745615 endingPage "e29160" @default.
• W2134745615 startingPage "e29160" @default.
• W2134745615 abstract "Transforming growth factor-β1 (TGF-β1) signaling plays a key role in vertebrate development, homeostasis, and disease. Nuclear factor I-C (NFI-C) has been implicated in TGF-β1 signaling, extracellular matrix gene transcription, and tooth root development. However, the functional relationship between NFI-C and TGF-β1 signaling remains uncharacterized. The purpose of this study was to identify the molecular interactions between NFI-C and TGF-β1 signaling in mouse odontoblasts. Real-time polymerase chain reaction and western analysis demonstrated that NFI-C expression levels were inversely proportional to levels of TGF-β1 signaling molecules during in vitro odontoblast differentiation. Western blot and immunofluorescence results showed that NFI-C was significantly degraded after TGF-β1 addition in odontoblasts, and the formation of the Smad3 complex was essential for NFI-C degradation. Additionally, ubiquitination assay results showed that Smurf1 and Smurf2 induced NFI-C degradation and polyubiquitination in a TGF-β1-dependent manner. Both kinase and in vitro binding assays revealed that the interaction between NFI-C and Smurf1/Smurf2 requires the activation of the mitogen-activated protein kinase pathway by TGF-β1. Moreover, degradation of NFI-C induced by TGF-β1 occurred generally in cell types other than odontoblasts in normal human breast epithelial cells. In contrast, NFI-C induced dephosphorylation of p-Smad2/3. These results show that crosstalk between NFI-C and TGF-β1 signaling regulates cell differentiation and homeostatic processes in odontoblasts, which might constitute a common cellular mechanism." @default.
• W2134745615 created "2016-06-24" @default.
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• W2134745615 date "2011-12-16" @default.
• W2134745615 modified "2023-10-14" @default.
• W2134745615 title "Crosstalk between Nuclear Factor I-C and Transforming Growth Factor-β1 Signaling Regulates Odontoblast Differentiation and Homeostasis" @default.
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• W2134745615 doi "https://doi.org/10.1371/journal.pone.0029160" @default.
• W2134745615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3241690" @default.
• W2134745615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22195013" @default.
• W2134745615 hasPublicationYear "2011" @default.
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