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• W2134756584 abstract "The binding and internalization of a circulating insect lipoprotein, high density lipophorin (HDLp), by in- sect fat body cells was studied at the electron-microscopic level using ultrasmall gold-labeled HDLp and DiI-labeled HDLp, which were visualized by silver enhancement and di- aminobenzidine photoconversion, respectively. Internaliza- tion of HDLp seems to conflict with the selective process by which the lipids are transported between HDLp and fat body cells. The pathway followed by the internalized lipo- proteins was investigated. In addition, the localizations of HDLp in fat body cells of young and older adult locusts were compared because of the previously reported age- related differences in distribution of cell-associated and in- ternalized HDLp. In the present study, internalized labeled HDLp was observed in early endosomes, late endosomes, and putative lysosomes. In older adults, these labeled struc- tures were much less abundant than in young adults. More- over, in these animals, the labeled endosomal/lysosomal vesicles were located close to the plasma membranes. A more intense labeling was observed in the extracellular ma- trix in older adults compared to young adults. In both de- velopmental stages, an apparent accumulation of labeled HDLp was found in extracellular spaces. We propose that this entrapment of HDLp may be essential for selective lipid transport between HDLp and fat body cells.— Dan- tuma, N. P., M. A. P. Pijnenburg, J. H. B. Diederen, and D. J. Van der Horst. Multiple interactions between insect lipopro- teins and fat body cells: extracellular trapping and en- docytic trafficking. J. Lipid Res. 1998. 39: 1877-1888." @default.
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• W2134756584 date "1998-09-01" @default.
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• W2134756584 title "Multiple interactions between insect lipoproteins and fat body cells: extracellular trapping and endocytic trafficking" @default.
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• W2134756584 doi "https://doi.org/10.1016/s0022-2275(20)32176-3" @default.
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