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- W2134764420 endingPage "1939" @default.
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- W2134764420 abstract "To date, 22 mitochondrial carrier subfamilies have been functionally identified based on substrate specificity. Structural, functional and bioinformatics studies have pointed to the existence in the mitochondrial carrier superfamily of a substrate-binding site in the internal carrier cavity, of two salt-bridge networks or gates that close the cavity alternatively on the matrix or the cytosolic side of the membrane, and of conserved prolines and glycines in the transmembrane alpha-helices. The significance of these properties in the structural changes occurring during the catalytic substrate translocation cycle are discussed within the context of a transport mechanism model. Most experimentally produced and disease-causing missense mutations concern carrier regions corresponding to the substrate-binding site, the two gates and the conserved prolines and glycines." @default.
- W2134764420 created "2016-06-24" @default.
- W2134764420 creator A5008679103 @default.
- W2134764420 creator A5090350551 @default.
- W2134764420 date "2009-10-25" @default.
- W2134764420 modified "2023-09-29" @default.
- W2134764420 title "Structure and function of mitochondrial carriers - Role of the transmembrane helix P and G residues in the gating and transport mechanism" @default.
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- W2134764420 cites W1982705299 @default.
- W2134764420 cites W1988936830 @default.
- W2134764420 cites W2000844947 @default.
- W2134764420 cites W2002139629 @default.
- W2134764420 cites W2004801196 @default.
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- W2134764420 doi "https://doi.org/10.1016/j.febslet.2009.10.063" @default.
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