FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134765536> ?p ?o ?g. }

• W2134765536 endingPage "353" @default.
• W2134765536 startingPage "342" @default.
• W2134765536 abstract "Microglia are pivotal in the pathogenesis of AIDS dementia, as they serve as the major target of HIV infection in the CNS. In addition, activation of microglia correlates best with clinical dementia. Although the beta-chemokine RANTES/CCL5 is important in modulating HIV infection as well as cellular activation, no information is available regarding how its expression is regulated in microglia by HIV-1. Here we report that RANTES/CCL5 expression is induced in microglia by HIV-1, but that this requires infection by HIV-1. This conclusion was supported by (1) the delayed kinetics coinciding with viral replication; (2) the lack of effect of X4 viruses; (3) inhibition by the reverse transcriptase inhibitor AZT, and (4) the lack of effect of cytokine antagonists or antibodies. Interestingly, RANTES/CCL5 production was dependent on the viral accessory protein Vpr, in addition to Nef, demonstrating a novel role for Vpr in chemokine induction in primary macrophage-type cells. Furthermore, the specific p38 MAP kinase inhibitor SB203580 augmented chemokine expression in microglia, indicating a negative role played by p38. These data suggest unique features of RANTES/CCL5 regulation by HIV-1 in human microglial cells." @default.
• W2134765536 created "2016-06-24" @default.
• W2134765536 creator A5033899914 @default.
• W2134765536 creator A5036106449 @default.
• W2134765536 creator A5057241613 @default.
• W2134765536 creator A5064164383 @default.
• W2134765536 creator A5074465550 @default.
• W2134765536 creator A5089011676 @default.
• W2134765536 date "2002-09-01" @default.
• W2134765536 modified "2023-10-10" @default.
• W2134765536 title "Vpr- and Nef-Dependent Induction of RANTES/CCL5 in Microglial Cells" @default.
• W2134765536 cites W1501736317 @default.
• W2134765536 cites W1502449443 @default.
• W2134765536 cites W1519144004 @default.
• W2134765536 cites W1581923386 @default.
• W2134765536 cites W1582483157 @default.
• W2134765536 cites W1644579564 @default.
• W2134765536 cites W1784761870 @default.
• W2134765536 cites W1807747199 @default.
• W2134765536 cites W1925504181 @default.
• W2134765536 cites W1945056250 @default.
• W2134765536 cites W1963855922 @default.
• W2134765536 cites W1970199508 @default.
• W2134765536 cites W1970524401 @default.
• W2134765536 cites W1976895949 @default.
• W2134765536 cites W1980334272 @default.
• W2134765536 cites W1981440980 @default.
• W2134765536 cites W1981644527 @default.
• W2134765536 cites W1986574361 @default.
• W2134765536 cites W1990709071 @default.
• W2134765536 cites W1990773400 @default.
• W2134765536 cites W1991556620 @default.
• W2134765536 cites W1993715125 @default.
• W2134765536 cites W1998310721 @default.
• W2134765536 cites W1999881215 @default.
• W2134765536 cites W2001243226 @default.
• W2134765536 cites W2007150582 @default.
• W2134765536 cites W2010840723 @default.
• W2134765536 cites W2014067369 @default.
• W2134765536 cites W2026829049 @default.
• W2134765536 cites W2027580727 @default.
• W2134765536 cites W2033204154 @default.
• W2134765536 cites W2035134338 @default.
• W2134765536 cites W2048662892 @default.
• W2134765536 cites W2052305221 @default.
• W2134765536 cites W2052750950 @default.
• W2134765536 cites W2053053546 @default.
• W2134765536 cites W2054395379 @default.
• W2134765536 cites W2056351034 @default.
• W2134765536 cites W2058458125 @default.
• W2134765536 cites W2059830137 @default.
• W2134765536 cites W2064557078 @default.
• W2134765536 cites W2065111916 @default.
• W2134765536 cites W2066280128 @default.
• W2134765536 cites W2068502127 @default.
• W2134765536 cites W2070144920 @default.
• W2134765536 cites W2072901265 @default.
• W2134765536 cites W2076407459 @default.
• W2134765536 cites W2077290004 @default.
• W2134765536 cites W2088894802 @default.
• W2134765536 cites W2092289188 @default.
• W2134765536 cites W2093410626 @default.
• W2134765536 cites W2093591607 @default.
• W2134765536 cites W2096374450 @default.
• W2134765536 cites W2097972613 @default.
• W2134765536 cites W2099141302 @default.
• W2134765536 cites W2123742407 @default.
• W2134765536 cites W2123804736 @default.
• W2134765536 cites W2125453887 @default.
• W2134765536 cites W2125759758 @default.
• W2134765536 cites W2126597682 @default.
• W2134765536 cites W2138567519 @default.
• W2134765536 cites W2147024161 @default.
• W2134765536 cites W2156636851 @default.
• W2134765536 cites W2157245965 @default.
• W2134765536 cites W2169211575 @default.
• W2134765536 cites W2336069963 @default.
• W2134765536 cites W233645389 @default.
• W2134765536 cites W2339922662 @default.
• W2134765536 cites W2342220526 @default.
• W2134765536 cites W4313333659 @default.
• W2134765536 cites W87068116 @default.
• W2134765536 doi "https://doi.org/10.1006/viro.2002.1613" @default.
• W2134765536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12359436" @default.
• W2134765536 hasPublicationYear "2002" @default.
• W2134765536 type Work @default.
• W2134765536 sameAs 2134765536 @default.
• W2134765536 citedByCount "44" @default.
• W2134765536 countsByYear W21347655362013 @default.
• W2134765536 countsByYear W21347655362014 @default.
• W2134765536 countsByYear W21347655362015 @default.
• W2134765536 countsByYear W21347655362016 @default.
• W2134765536 countsByYear W21347655362017 @default.
• W2134765536 countsByYear W21347655362018 @default.
• W2134765536 countsByYear W21347655362020 @default.
• W2134765536 countsByYear W21347655362023 @default.
• W2134765536 crossrefType "journal-article" @default.
• W2134765536 hasAuthorship W2134765536A5033899914 @default.

• next