Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134766850> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2134766850 abstract "Newborn Swiss-Webster mice were given an intraperitoneal injection of 25 μg of dimethylnitrosamine. At weaning they began receiving 0.05% phenobarbital in the drinking water to promote the lesions for the term of the study. Preneoplastic foci and hyperplastic nodules were identified histologically by two markers, resistance to exogenous iron accumulation and an increase in γ-glutamyltranspeptidase activity. AT 8, 12, and 16 weeks of age, livers of affected male mice exhibited 12, 18, and 12 iron-resistant foci/cm 2 and 13, 9, and 9 γ-glutamyltranspeptidase-positive foci/cm 2 , respectively (average for median right and right anterior sublobes). Iron-resistant nodules were first observed at 8 weeks; however, γ-glutamyltranspeptidase-positive nodules were not noted until 12 weeks. In animals that received dimethylnitrosamine but were not placed on phenobarbital, there was an average of 5 foci/cm 2 (iron-resistant or γ-glutamyltranspeptidase-positive) at 12 weeks while no nodules were noted. This model could provide a practical short-term in vivo tool for the detection of early sequential cellular alterations produced by initiators, inhibitors, and promoters of carcinogenesis." @default.
- W2134766850 created "2016-06-24" @default.
- W2134766850 creator A5012629222 @default.
- W2134766850 creator A5028679979 @default.
- W2134766850 creator A5050360179 @default.
- W2134766850 date "1985-01-01" @default.
- W2134766850 modified "2023-09-27" @default.
- W2134766850 title "Characterization of Dimethylnitrosamineinduced Focal and Nodular Lesions in the Livers of Newborn Mice" @default.
- W2134766850 cites W1933675523 @default.
- W2134766850 cites W1966789643 @default.
- W2134766850 cites W1992540658 @default.
- W2134766850 cites W2067895109 @default.
- W2134766850 cites W2072377878 @default.
- W2134766850 cites W2072891772 @default.
- W2134766850 cites W2081290307 @default.
- W2134766850 cites W2247618723 @default.
- W2134766850 cites W2291956401 @default.
- W2134766850 doi "https://doi.org/10.1177/019262338501300102" @default.
- W2134766850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2863866" @default.
- W2134766850 hasPublicationYear "1985" @default.
- W2134766850 type Work @default.
- W2134766850 sameAs 2134766850 @default.
- W2134766850 citedByCount "15" @default.
- W2134766850 crossrefType "journal-article" @default.
- W2134766850 hasAuthorship W2134766850A5012629222 @default.
- W2134766850 hasAuthorship W2134766850A5028679979 @default.
- W2134766850 hasAuthorship W2134766850A5050360179 @default.
- W2134766850 hasConcept C121608353 @default.
- W2134766850 hasConcept C126322002 @default.
- W2134766850 hasConcept C134018914 @default.
- W2134766850 hasConcept C142724271 @default.
- W2134766850 hasConcept C2778793413 @default.
- W2134766850 hasConcept C2780159080 @default.
- W2134766850 hasConcept C2780655333 @default.
- W2134766850 hasConcept C555283112 @default.
- W2134766850 hasConcept C71924100 @default.
- W2134766850 hasConceptScore W2134766850C121608353 @default.
- W2134766850 hasConceptScore W2134766850C126322002 @default.
- W2134766850 hasConceptScore W2134766850C134018914 @default.
- W2134766850 hasConceptScore W2134766850C142724271 @default.
- W2134766850 hasConceptScore W2134766850C2778793413 @default.
- W2134766850 hasConceptScore W2134766850C2780159080 @default.
- W2134766850 hasConceptScore W2134766850C2780655333 @default.
- W2134766850 hasConceptScore W2134766850C555283112 @default.
- W2134766850 hasConceptScore W2134766850C71924100 @default.
- W2134766850 hasLocation W21347668501 @default.
- W2134766850 hasLocation W21347668502 @default.
- W2134766850 hasOpenAccess W2134766850 @default.
- W2134766850 hasPrimaryLocation W21347668501 @default.
- W2134766850 hasRelatedWork W119422928 @default.
- W2134766850 hasRelatedWork W2004424018 @default.
- W2134766850 hasRelatedWork W2023061771 @default.
- W2134766850 hasRelatedWork W2029404382 @default.
- W2134766850 hasRelatedWork W2038999535 @default.
- W2134766850 hasRelatedWork W2045295079 @default.
- W2134766850 hasRelatedWork W2092849470 @default.
- W2134766850 hasRelatedWork W2156112350 @default.
- W2134766850 hasRelatedWork W2259254025 @default.
- W2134766850 hasRelatedWork W560722010 @default.
- W2134766850 isParatext "false" @default.
- W2134766850 isRetracted "false" @default.
- W2134766850 magId "2134766850" @default.
- W2134766850 workType "article" @default.