FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134770425> ?p ?o ?g. }

• W2134770425 endingPage "168" @default.
• W2134770425 startingPage "158" @default.
• W2134770425 abstract "Hypoxia induces the survival and regenerative potential of adipose-derived stem cells (ASCs), but there are tremendous needs to find alternative methods for ASC preconditioning. Therefore, this work investigated: (1) the ability of low-dose ultraviolet B (UVB) radiation to stimulate the survival, migration, and tube-forming activity of ASCs in vitro; (2) the ability of UVB preconditioning to enhance the hair growth-promoting capacity of ASCs in vivo; and (3) the mechanism of action for ASC stimulation by UVB. Although high-dose UVB decreased the proliferation of ASCs, low-dose (10 or 20 mJ/cm(2)) treatment increased their survival, migration, and tube-forming activity. In addition, low-dose UVB upregulated the expression of ASC-derived growth factors, and a culture medium conditioned by UVB-irradiated ASCs increased the proliferation of dermal papilla and outer root sheet cells. Notably, injection of UVB-preconditioned ASCs into C(3)H/HeN mice significantly induced the telogen-to-anagen transition and increased new hair weight in vivo. UVB treatment significantly increased the generation of reactive oxygen species (ROS) in cultured ASCs, and inhibition of ROS generation by diphenyleneiodonium chloride (DPI) significantly attenuated UVB-induced ASC stimulation. Furthermore, NADPH oxidase 4 (Nox4) expression was induced in ASCs by UVB irradiation, and Nox4 silencing by small interfering RNA, like DPI, significantly reduced UVB-induced ROS generation. These results suggest that the primary involvement of ROS generation in UVB-mediated ASC stimulation occurs via the Nox4 enzyme. This is the first indication that a low dose of UVB radiation and/or the control of ROS generation could potentially be incorporated into a novel ASC preconditioning method for hair regeneration." @default.
• W2134770425 created "2016-06-24" @default.
• W2134770425 creator A5007631995 @default.
• W2134770425 creator A5015079431 @default.
• W2134770425 creator A5015092206 @default.
• W2134770425 creator A5015104479 @default.
• W2134770425 creator A5019897388 @default.
• W2134770425 creator A5051135646 @default.
• W2134770425 creator A5052464072 @default.
• W2134770425 creator A5089641474 @default.
• W2134770425 date "2013-01-01" @default.
• W2134770425 modified "2023-09-26" @default.
• W2134770425 title "Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species" @default.
• W2134770425 cites W1508798545 @default.
• W2134770425 cites W1592390749 @default.
• W2134770425 cites W1964872204 @default.
• W2134770425 cites W1973098405 @default.
• W2134770425 cites W1973768763 @default.
• W2134770425 cites W1975822477 @default.
• W2134770425 cites W1984190184 @default.
• W2134770425 cites W1986997109 @default.
• W2134770425 cites W1988051690 @default.
• W2134770425 cites W1988087076 @default.
• W2134770425 cites W1990386050 @default.
• W2134770425 cites W1995168386 @default.
• W2134770425 cites W1998276799 @default.
• W2134770425 cites W2004072752 @default.
• W2134770425 cites W2007853610 @default.
• W2134770425 cites W2012557678 @default.
• W2134770425 cites W2018639383 @default.
• W2134770425 cites W2021634519 @default.
• W2134770425 cites W2022025205 @default.
• W2134770425 cites W2026271674 @default.
• W2134770425 cites W2032272551 @default.
• W2134770425 cites W2042690168 @default.
• W2134770425 cites W2045305474 @default.
• W2134770425 cites W2062763609 @default.
• W2134770425 cites W2073939513 @default.
• W2134770425 cites W2074344996 @default.
• W2134770425 cites W2076229475 @default.
• W2134770425 cites W2076569367 @default.
• W2134770425 cites W2084719402 @default.
• W2134770425 cites W2107428938 @default.
• W2134770425 cites W2110234623 @default.
• W2134770425 cites W2110386855 @default.
• W2134770425 cites W2112862143 @default.
• W2134770425 cites W2115849216 @default.
• W2134770425 cites W2128507677 @default.
• W2134770425 cites W2149565005 @default.
• W2134770425 cites W2151262495 @default.
• W2134770425 cites W2158598681 @default.
• W2134770425 cites W2159232709 @default.
• W2134770425 cites W2172378021 @default.
• W2134770425 doi "https://doi.org/10.1089/scd.2012.0167" @default.
• W2134770425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3528093" @default.
• W2134770425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22784094" @default.
• W2134770425 hasPublicationYear "2013" @default.
• W2134770425 type Work @default.
• W2134770425 sameAs 2134770425 @default.
• W2134770425 citedByCount "39" @default.
• W2134770425 countsByYear W21347704252013 @default.
• W2134770425 countsByYear W21347704252014 @default.
• W2134770425 countsByYear W21347704252015 @default.
• W2134770425 countsByYear W21347704252016 @default.
• W2134770425 countsByYear W21347704252017 @default.
• W2134770425 countsByYear W21347704252018 @default.
• W2134770425 countsByYear W21347704252019 @default.
• W2134770425 countsByYear W21347704252020 @default.
• W2134770425 countsByYear W21347704252021 @default.
• W2134770425 countsByYear W21347704252022 @default.
• W2134770425 countsByYear W21347704252023 @default.
• W2134770425 crossrefType "journal-article" @default.
• W2134770425 hasAuthorship W2134770425A5007631995 @default.
• W2134770425 hasAuthorship W2134770425A5015079431 @default.
• W2134770425 hasAuthorship W2134770425A5015092206 @default.
• W2134770425 hasAuthorship W2134770425A5015104479 @default.
• W2134770425 hasAuthorship W2134770425A5019897388 @default.
• W2134770425 hasAuthorship W2134770425A5051135646 @default.
• W2134770425 hasAuthorship W2134770425A5052464072 @default.
• W2134770425 hasAuthorship W2134770425A5089641474 @default.
• W2134770425 hasBestOaLocation W21347704252 @default.
• W2134770425 hasConcept C104317684 @default.
• W2134770425 hasConcept C119056186 @default.
• W2134770425 hasConcept C153911025 @default.
• W2134770425 hasConcept C2779719074 @default.
• W2134770425 hasConcept C2779765511 @default.
• W2134770425 hasConcept C28328180 @default.
• W2134770425 hasConcept C48349386 @default.
• W2134770425 hasConcept C502942594 @default.
• W2134770425 hasConcept C55493867 @default.
• W2134770425 hasConcept C86803240 @default.
• W2134770425 hasConcept C95444343 @default.
• W2134770425 hasConcept C98274493 @default.
• W2134770425 hasConceptScore W2134770425C104317684 @default.
• W2134770425 hasConceptScore W2134770425C119056186 @default.
• W2134770425 hasConceptScore W2134770425C153911025 @default.
• W2134770425 hasConceptScore W2134770425C2779719074 @default.
• W2134770425 hasConceptScore W2134770425C2779765511 @default.

• next