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• W2134776341 abstract "Staphylococcal enterotoxins are potent activators for human T cells and cause lethal toxic shock. Rapamycin, an immunosuppressant, was tested for its ability to inhibit staphylococcal enterotoxin B (SEB)-induced activation of human peripheral blood mononuclear cells (PBMC) in vitro and toxin-mediated shock in mice. Stimulation of PMBC by SEB was effectively blocked by rapamycin as evidenced by the inhibition of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), IL-6, IL-2, gamma interferon (IFN-gamma), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, and T-cell proliferation. In vivo, rapamycin protected 100% of mice from lethal shock, even when administered 24 h after intranasal SEB challenge. The serum levels of MCP-1 and IL-6, after intranasal exposure to SEB, were significantly reduced in mice given rapamycin versus controls. Additionally, rapamycin diminished the weight loss and temperature fluctuations elicited by SEB." @default.
• W2134776341 created "2016-06-24" @default.
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• W2134776341 date "2010-03-01" @default.
• W2134776341 modified "2023-09-23" @default.
• W2134776341 title "Rapamycin Protects Mice from Staphylococcal Enterotoxin B-Induced Toxic Shock and Blocks Cytokine Release<i>In</i><i>V</i><i>itro</i>and<i>In Vivo</i>" @default.
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• W2134776341 doi "https://doi.org/10.1128/aac.01015-09" @default.
• W2134776341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2825991" @default.
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• W2134776341 hasPublicationYear "2010" @default.
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