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- W2134785655 abstract "The mechanisms controlling the interaction between energy balance & reproduction are still a subject of intensive investigation in mammals. Animal diet is usually supplemented with polyunsaturated fatty acid to combat energy imbalance. It has been found, particularly in cattle and buffaloes, dietary fats influence reproductive function as it has been observed that fatty acid supplementation in the diet increases the follicle number & stimulates the growth of preovulatory follicle i.e. follicular maturation. The integrated control of folliculogenesis is probably a multifaceted phenomenon involving an array of signals governing energy homeostasis, metabolism & fertility. The levels of various molecules, including metabolites (glucose, fatty acids, amino acids) and hormones (Adiponectin, insulin, leptin, ghrelin, etc.), are modulated by nutrition and energy supply. Most of these molecules are known to be directly involved, through fuel sensors, in the regulation of fertility at each level of the hypothalamo-pituitary-gonad axis. One such fuel sensor, PPARs -a superfamily of nuclear receptors, expressed in ovary, has been found to be involved in various aspects of ovarian function and hence raising the question about biological actions of PPARs in fertility. In general, PPARs mediates their effect through their ligands (Endogenous ligands- PUFA and Exogenous ligands- Herbicide, Thiazolidinediones, plasticizers) and alter target gene expression. In the present study CLA and rosiglitazone has been chosen as endogenous and exogenous ligands, respectively. Recently, we cloned, characterized and identified a novel PPARγ transcripts in buffalo ovary and elucidated molecular mechanism how PPARγ could influence the buffalo fertility under different pathophysiological conditions." @default.
- W2134785655 created "2016-06-24" @default.
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- W2134785655 date "2013-01-01" @default.
- W2134785655 modified "2023-09-25" @default.
- W2134785655 title "Fuel Sensor PPARγ: a Potential Gateway for Fertility Regulation in Buffalo" @default.
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