Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134789423> ?p ?o ?g. }
- W2134789423 endingPage "2820" @default.
- W2134789423 startingPage "2808" @default.
- W2134789423 abstract "Stem cell–based therapy has been proposed as a potential means of treatment for a variety of brain disorders. Because ethical and technical issues have so far limited the clinical translation of research using embryonic/fetal cells and neural tissue, respectively, the search for alternative sources of therapeutic stem cells remains ongoing. Here, we report that upon transplantation into mice with chemically induced hippocampal lesions, human olfactory ecto–mesenchymal stem cells (OE-MSCs) — adult stem cells from human nasal olfactory lamina propria — migrated toward the sites of neural damage, where they differentiated into neurons. Additionally, transplanted OE-MSCs stimulated endogenous neurogenesis, restored synaptic transmission, and enhanced long-term potentiation. Mice that received transplanted OE-MSCs exhibited restoration of learning and memory on behavioral tests compared with lesioned, nontransplanted control mice. Similar results were obtained when OE-MSCs were injected into the cerebrospinal fluid. These data show that OE-MSCs can induce neurogenesis and contribute to restoration of hippocampal neuronal networks via trophic actions. They provide evidence that human olfactory tissue is a conceivable source of nervous system replacement cells. This stem cell subtype may be useful for a broad range of stem cell–related studies." @default.
- W2134789423 created "2016-06-24" @default.
- W2134789423 creator A5001939150 @default.
- W2134789423 creator A5016073712 @default.
- W2134789423 creator A5016114671 @default.
- W2134789423 creator A5024005264 @default.
- W2134789423 creator A5029317841 @default.
- W2134789423 creator A5045453270 @default.
- W2134789423 creator A5065511892 @default.
- W2134789423 creator A5067746784 @default.
- W2134789423 creator A5079937209 @default.
- W2134789423 creator A5082652373 @default.
- W2134789423 creator A5084454637 @default.
- W2134789423 date "2011-07-01" @default.
- W2134789423 modified "2023-10-15" @default.
- W2134789423 title "Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions" @default.
- W2134789423 cites W1967948196 @default.
- W2134789423 cites W1970822990 @default.
- W2134789423 cites W1975596483 @default.
- W2134789423 cites W1979043688 @default.
- W2134789423 cites W1979326353 @default.
- W2134789423 cites W1980723823 @default.
- W2134789423 cites W1983226940 @default.
- W2134789423 cites W1993637512 @default.
- W2134789423 cites W2000940725 @default.
- W2134789423 cites W2010795621 @default.
- W2134789423 cites W2012618391 @default.
- W2134789423 cites W2021461511 @default.
- W2134789423 cites W2033223071 @default.
- W2134789423 cites W2034387476 @default.
- W2134789423 cites W2035975399 @default.
- W2134789423 cites W2037884107 @default.
- W2134789423 cites W2040900588 @default.
- W2134789423 cites W2043366308 @default.
- W2134789423 cites W2048731214 @default.
- W2134789423 cites W2061111257 @default.
- W2134789423 cites W2063466545 @default.
- W2134789423 cites W2065465258 @default.
- W2134789423 cites W2069492667 @default.
- W2134789423 cites W2071333811 @default.
- W2134789423 cites W2076511175 @default.
- W2134789423 cites W2077852611 @default.
- W2134789423 cites W2078592129 @default.
- W2134789423 cites W2079054696 @default.
- W2134789423 cites W2080223719 @default.
- W2134789423 cites W2080718047 @default.
- W2134789423 cites W2087817961 @default.
- W2134789423 cites W2087977249 @default.
- W2134789423 cites W2089843598 @default.
- W2134789423 cites W2092921145 @default.
- W2134789423 cites W2093777952 @default.
- W2134789423 cites W2094606090 @default.
- W2134789423 cites W2094958540 @default.
- W2134789423 cites W2095102390 @default.
- W2134789423 cites W2107890140 @default.
- W2134789423 cites W2108324820 @default.
- W2134789423 cites W2108488819 @default.
- W2134789423 cites W2109298779 @default.
- W2134789423 cites W2116918434 @default.
- W2134789423 cites W2119174145 @default.
- W2134789423 cites W2122120311 @default.
- W2134789423 cites W2131316234 @default.
- W2134789423 cites W2133188546 @default.
- W2134789423 cites W2135652919 @default.
- W2134789423 cites W2138462240 @default.
- W2134789423 cites W2144843689 @default.
- W2134789423 cites W2148336088 @default.
- W2134789423 cites W2149766411 @default.
- W2134789423 cites W2162800365 @default.
- W2134789423 cites W2168341415 @default.
- W2134789423 cites W2169473035 @default.
- W2134789423 cites W2171292002 @default.
- W2134789423 cites W2318189907 @default.
- W2134789423 cites W2334461448 @default.
- W2134789423 doi "https://doi.org/10.1172/jci44489" @default.
- W2134789423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3223823" @default.
- W2134789423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21670501" @default.
- W2134789423 hasPublicationYear "2011" @default.
- W2134789423 type Work @default.
- W2134789423 sameAs 2134789423 @default.
- W2134789423 citedByCount "97" @default.
- W2134789423 countsByYear W21347894232012 @default.
- W2134789423 countsByYear W21347894232013 @default.
- W2134789423 countsByYear W21347894232014 @default.
- W2134789423 countsByYear W21347894232015 @default.
- W2134789423 countsByYear W21347894232016 @default.
- W2134789423 countsByYear W21347894232017 @default.
- W2134789423 countsByYear W21347894232018 @default.
- W2134789423 countsByYear W21347894232019 @default.
- W2134789423 countsByYear W21347894232020 @default.
- W2134789423 countsByYear W21347894232021 @default.
- W2134789423 countsByYear W21347894232022 @default.
- W2134789423 countsByYear W21347894232023 @default.
- W2134789423 crossrefType "journal-article" @default.
- W2134789423 hasAuthorship W2134789423A5001939150 @default.
- W2134789423 hasAuthorship W2134789423A5016073712 @default.
- W2134789423 hasAuthorship W2134789423A5016114671 @default.
- W2134789423 hasAuthorship W2134789423A5024005264 @default.