FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134790706> ?p ?o ?g. }

• W2134790706 endingPage "3355" @default.
• W2134790706 startingPage "3349" @default.
• W2134790706 abstract "Inspired from preconditioning studies, ischemic postconditioning, consisting of the application of intermittent interruptions of blood flow shortly after reperfusion, has been described in cardiac ischemia and recently in stroke. It is well known that ischemic tolerance can be achieved in the brain not only by ischemic preconditioning, but also by hypoxic preconditioning. However, the existence of hypoxic postconditioning has never been reported in cerebral ischemia.Adult mice subjected to transient middle cerebral artery occlusion underwent chronic intermittent hypoxia starting either 1 or 5 days after ischemia and brain damage was assessed by T2-weighted MRI at 43 days. In addition, we investigated the potential neuroprotective effect of hypoxia applied after oxygen glucose deprivation in primary neuronal cultures.The present study shows for the first time that a late application of hypoxia (5 days) after ischemia reduced delayed thalamic atrophy. Furthermore, hypoxia performed 14 hours after oxygen glucose deprivation induced neuroprotection in primary neuronal cultures. We found that hypoxia-inducible factor-1alpha expression as well as those of its target genes erythropoietin and adrenomedullin is increased by hypoxic postconditioning. Further studies with pharmacological inhibitors or recombinant proteins for erythropoietin and adrenomedullin revealed that these molecules participate in this hypoxia postconditioning-induced neuroprotection.Altogether, this study demonstrates for the first time the existence of a delayed hypoxic postconditioning in cerebral ischemia and in vitro studies highlight hypoxia-inducible factor-1alpha and its target genes, erythropoietin and adrenomedullin, as potential effectors of postconditioning." @default.
• W2134790706 created "2016-06-24" @default.
• W2134790706 creator A5003180492 @default.
• W2134790706 creator A5003231684 @default.
• W2134790706 creator A5008847045 @default.
• W2134790706 creator A5042295971 @default.
• W2134790706 creator A5044263958 @default.
• W2134790706 creator A5045793384 @default.
• W2134790706 creator A5051154319 @default.
• W2134790706 creator A5064429156 @default.
• W2134790706 creator A5065672564 @default.
• W2134790706 date "2009-10-01" @default.
• W2134790706 modified "2023-10-03" @default.
• W2134790706 title "Delayed Hypoxic Postconditioning Protects Against Cerebral Ischemia in the Mouse" @default.
• W2134790706 cites W1607343635 @default.
• W2134790706 cites W1823048099 @default.
• W2134790706 cites W1988090725 @default.
• W2134790706 cites W1997966386 @default.
• W2134790706 cites W2025146799 @default.
• W2134790706 cites W2038108333 @default.
• W2134790706 cites W2038297077 @default.
• W2134790706 cites W2041969644 @default.
• W2134790706 cites W2063175209 @default.
• W2134790706 cites W2068488670 @default.
• W2134790706 cites W2094393593 @default.
• W2134790706 cites W2100463961 @default.
• W2134790706 cites W2134704000 @default.
• W2134790706 cites W2137445925 @default.
• W2134790706 cites W2143058635 @default.
• W2134790706 cites W2155022212 @default.
• W2134790706 cites W2170324862 @default.
• W2134790706 cites W4366065637 @default.
• W2134790706 doi "https://doi.org/10.1161/strokeaha.109.557314" @default.
• W2134790706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19628803" @default.
• W2134790706 hasPublicationYear "2009" @default.
• W2134790706 type Work @default.
• W2134790706 sameAs 2134790706 @default.
• W2134790706 citedByCount "91" @default.
• W2134790706 countsByYear W21347907062012 @default.
• W2134790706 countsByYear W21347907062013 @default.
• W2134790706 countsByYear W21347907062014 @default.
• W2134790706 countsByYear W21347907062015 @default.
• W2134790706 countsByYear W21347907062016 @default.
• W2134790706 countsByYear W21347907062017 @default.
• W2134790706 countsByYear W21347907062018 @default.
• W2134790706 countsByYear W21347907062019 @default.
• W2134790706 countsByYear W21347907062020 @default.
• W2134790706 countsByYear W21347907062021 @default.
• W2134790706 countsByYear W21347907062022 @default.
• W2134790706 countsByYear W21347907062023 @default.
• W2134790706 crossrefType "journal-article" @default.
• W2134790706 hasAuthorship W2134790706A5003180492 @default.
• W2134790706 hasAuthorship W2134790706A5003231684 @default.
• W2134790706 hasAuthorship W2134790706A5008847045 @default.
• W2134790706 hasAuthorship W2134790706A5042295971 @default.
• W2134790706 hasAuthorship W2134790706A5044263958 @default.
• W2134790706 hasAuthorship W2134790706A5045793384 @default.
• W2134790706 hasAuthorship W2134790706A5051154319 @default.
• W2134790706 hasAuthorship W2134790706A5064429156 @default.
• W2134790706 hasAuthorship W2134790706A5065672564 @default.
• W2134790706 hasBestOaLocation W21347907061 @default.
• W2134790706 hasConcept C126322002 @default.
• W2134790706 hasConcept C127413603 @default.
• W2134790706 hasConcept C170493617 @default.
• W2134790706 hasConcept C178790620 @default.
• W2134790706 hasConcept C185592680 @default.
• W2134790706 hasConcept C25498285 @default.
• W2134790706 hasConcept C2777152744 @default.
• W2134790706 hasConcept C2778534260 @default.
• W2134790706 hasConcept C2780645631 @default.
• W2134790706 hasConcept C42219234 @default.
• W2134790706 hasConcept C540031477 @default.
• W2134790706 hasConcept C541997718 @default.
• W2134790706 hasConcept C71924100 @default.
• W2134790706 hasConcept C7836513 @default.
• W2134790706 hasConcept C78519656 @default.
• W2134790706 hasConcept C98274493 @default.
• W2134790706 hasConceptScore W2134790706C126322002 @default.
• W2134790706 hasConceptScore W2134790706C127413603 @default.
• W2134790706 hasConceptScore W2134790706C170493617 @default.
• W2134790706 hasConceptScore W2134790706C178790620 @default.
• W2134790706 hasConceptScore W2134790706C185592680 @default.
• W2134790706 hasConceptScore W2134790706C25498285 @default.
• W2134790706 hasConceptScore W2134790706C2777152744 @default.
• W2134790706 hasConceptScore W2134790706C2778534260 @default.
• W2134790706 hasConceptScore W2134790706C2780645631 @default.
• W2134790706 hasConceptScore W2134790706C42219234 @default.
• W2134790706 hasConceptScore W2134790706C540031477 @default.
• W2134790706 hasConceptScore W2134790706C541997718 @default.
• W2134790706 hasConceptScore W2134790706C71924100 @default.
• W2134790706 hasConceptScore W2134790706C7836513 @default.
• W2134790706 hasConceptScore W2134790706C78519656 @default.
• W2134790706 hasConceptScore W2134790706C98274493 @default.
• W2134790706 hasIssue "10" @default.
• W2134790706 hasLocation W21347907061 @default.
• W2134790706 hasLocation W21347907062 @default.
• W2134790706 hasLocation W21347907063 @default.
• W2134790706 hasLocation W21347907064 @default.

• next