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- W2134794102 abstract "G-quadruplexes are higher-order nucleic acid structures that can form in G-rich telomeres and promoter regions of oncogenes. Telomeric quadruplex stabilization by small molecules can lead to telomere uncapping, followed by DNA damage response and senescence, as well as chromosomal fusions leading to deregulation of mitosis, followed by apoptosis and downregulation of oncogene expression. We report here on investigations into the mechanism of action of tetra-substituted naphthalene diimide ligands on the basis of cell biologic data together with a National Cancer Institute COMPARE study. We conclude that four principal mechanisms of action are implicated for these compounds: 1) telomere uncapping with subsequent DNA damage response and senescence; 2) inhibition of transcription/translation of oncogenes; 3) genomic instability through telomeric DNA end fusions, resulting in mitotic catastrophe and apoptosis; and 4) induction of chromosomal instability by telomere aggregate formation." @default.
- W2134794102 created "2016-06-24" @default.
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- W2134794102 date "2012-11-27" @default.
- W2134794102 modified "2023-10-16" @default.
- W2134794102 title "Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands" @default.
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- W2134794102 doi "https://doi.org/10.1124/mol.112.081075" @default.
- W2134794102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3558810" @default.
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