FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134798699> ?p ?o ?g. }

• W2134798699 endingPage "e97" @default.
• W2134798699 startingPage "e97" @default.
• W2134798699 abstract "ObjectiveSome authors describe similar and high fertilization and pregnancy rates in non-obstructive azoospermia (NOA) patients whereas others report lower outcomes in NOA than in obstructive azoospermia (OA) patients. Sperm DNA damage is associated with reduced fertilization rates, embryo quality and pregnancy rates and higher rates of spontaneous miscarriage and childhood disease. Meanwhile, mouse zygotes respond to sperm DNA damage through a non-apoptotic mechanism that acts by slowing paternal DNA replication and embryonic development. In this study, we compared the early development of embryos fertilized with NOA and OA spermatozoa by using time-lapse monitoring system.DesignThis is a retrospective study.Materials and MethodsSix oocytes with ICSI using testicular spermatozoa from NOA and 35 oocytes with OA from 2013 to 2014 were used. The exact times for each embryo division and developmental parameters were calculated in hours after ICSI. Time-lapse images of each embryo were retrospectively analyzed by PrimoVision software. The developmental events observed in each embryo were at the time of the visibility of two pronuclei (2PN), syngamy, two cells and four cells. These parameters were compared between the NOA group and the OA group.ResultsThe time of the visibility of 2PN in the NOA group (9.5±1.4 hours) was significantly earlier than that in the OA group (12.1±2.3 hours). However, the time from the visibility of 2PN to the syngamy in the NOA group (13.2±3.4 hours) was significantly longer than that in the OA group (10.6±2.7 hours). The time between the syngamy and the two cells in the NOA group (12.2±1.3 hours) was comparable with that in the OA group (16.6±10.2 hours). The time from the two cells to the four cells in the NOA group (13.5±3.5 hours) was also comparable with that in the OA group (10.0±4.2 hours).ConclusionThe time from the visibility of 2PN to the pronuclear fading (syngamy) after ICSI with testicular spermatozoa from NOA was prolonged compared to that after ICSI with testicular spermatozoa from OA. ObjectiveSome authors describe similar and high fertilization and pregnancy rates in non-obstructive azoospermia (NOA) patients whereas others report lower outcomes in NOA than in obstructive azoospermia (OA) patients. Sperm DNA damage is associated with reduced fertilization rates, embryo quality and pregnancy rates and higher rates of spontaneous miscarriage and childhood disease. Meanwhile, mouse zygotes respond to sperm DNA damage through a non-apoptotic mechanism that acts by slowing paternal DNA replication and embryonic development. In this study, we compared the early development of embryos fertilized with NOA and OA spermatozoa by using time-lapse monitoring system. Some authors describe similar and high fertilization and pregnancy rates in non-obstructive azoospermia (NOA) patients whereas others report lower outcomes in NOA than in obstructive azoospermia (OA) patients. Sperm DNA damage is associated with reduced fertilization rates, embryo quality and pregnancy rates and higher rates of spontaneous miscarriage and childhood disease. Meanwhile, mouse zygotes respond to sperm DNA damage through a non-apoptotic mechanism that acts by slowing paternal DNA replication and embryonic development. In this study, we compared the early development of embryos fertilized with NOA and OA spermatozoa by using time-lapse monitoring system. DesignThis is a retrospective study. This is a retrospective study. Materials and MethodsSix oocytes with ICSI using testicular spermatozoa from NOA and 35 oocytes with OA from 2013 to 2014 were used. The exact times for each embryo division and developmental parameters were calculated in hours after ICSI. Time-lapse images of each embryo were retrospectively analyzed by PrimoVision software. The developmental events observed in each embryo were at the time of the visibility of two pronuclei (2PN), syngamy, two cells and four cells. These parameters were compared between the NOA group and the OA group. Six oocytes with ICSI using testicular spermatozoa from NOA and 35 oocytes with OA from 2013 to 2014 were used. The exact times for each embryo division and developmental parameters were calculated in hours after ICSI. Time-lapse images of each embryo were retrospectively analyzed by PrimoVision software. The developmental events observed in each embryo were at the time of the visibility of two pronuclei (2PN), syngamy, two cells and four cells. These parameters were compared between the NOA group and the OA group. ResultsThe time of the visibility of 2PN in the NOA group (9.5±1.4 hours) was significantly earlier than that in the OA group (12.1±2.3 hours). However, the time from the visibility of 2PN to the syngamy in the NOA group (13.2±3.4 hours) was significantly longer than that in the OA group (10.6±2.7 hours). The time between the syngamy and the two cells in the NOA group (12.2±1.3 hours) was comparable with that in the OA group (16.6±10.2 hours). The time from the two cells to the four cells in the NOA group (13.5±3.5 hours) was also comparable with that in the OA group (10.0±4.2 hours). The time of the visibility of 2PN in the NOA group (9.5±1.4 hours) was significantly earlier than that in the OA group (12.1±2.3 hours). However, the time from the visibility of 2PN to the syngamy in the NOA group (13.2±3.4 hours) was significantly longer than that in the OA group (10.6±2.7 hours). The time between the syngamy and the two cells in the NOA group (12.2±1.3 hours) was comparable with that in the OA group (16.6±10.2 hours). The time from the two cells to the four cells in the NOA group (13.5±3.5 hours) was also comparable with that in the OA group (10.0±4.2 hours). ConclusionThe time from the visibility of 2PN to the pronuclear fading (syngamy) after ICSI with testicular spermatozoa from NOA was prolonged compared to that after ICSI with testicular spermatozoa from OA. The time from the visibility of 2PN to the pronuclear fading (syngamy) after ICSI with testicular spermatozoa from NOA was prolonged compared to that after ICSI with testicular spermatozoa from OA." @default.
• W2134798699 created "2016-06-24" @default.
• W2134798699 creator A5002904608 @default.
• W2134798699 creator A5015027107 @default.
• W2134798699 creator A5054747843 @default.
• W2134798699 creator A5063952771 @default.
• W2134798699 creator A5081929307 @default.
• W2134798699 date "2014-09-01" @default.
• W2134798699 modified "2023-09-30" @default.
• W2134798699 title "Human zygotes respond to sperm DNA damage by slowing DNA replication" @default.
• W2134798699 doi "https://doi.org/10.1016/j.fertnstert.2014.07.329" @default.
• W2134798699 hasPublicationYear "2014" @default.
• W2134798699 type Work @default.
• W2134798699 sameAs 2134798699 @default.
• W2134798699 citedByCount "0" @default.
• W2134798699 crossrefType "journal-article" @default.
• W2134798699 hasAuthorship W2134798699A5002904608 @default.
• W2134798699 hasAuthorship W2134798699A5015027107 @default.
• W2134798699 hasAuthorship W2134798699A5054747843 @default.
• W2134798699 hasAuthorship W2134798699A5063952771 @default.
• W2134798699 hasAuthorship W2134798699A5081929307 @default.
• W2134798699 hasBestOaLocation W21347986991 @default.
• W2134798699 hasConcept C110758877 @default.
• W2134798699 hasConcept C16685009 @default.
• W2134798699 hasConcept C196843134 @default.
• W2134798699 hasConcept C2777420699 @default.
• W2134798699 hasConcept C2777688143 @default.
• W2134798699 hasConcept C2779234561 @default.
• W2134798699 hasConcept C2779245376 @default.
• W2134798699 hasConcept C2781087480 @default.
• W2134798699 hasConcept C28748434 @default.
• W2134798699 hasConcept C54355233 @default.
• W2134798699 hasConcept C71924100 @default.
• W2134798699 hasConcept C86803240 @default.
• W2134798699 hasConcept C87073359 @default.
• W2134798699 hasConcept C88972607 @default.
• W2134798699 hasConceptScore W2134798699C110758877 @default.
• W2134798699 hasConceptScore W2134798699C16685009 @default.
• W2134798699 hasConceptScore W2134798699C196843134 @default.
• W2134798699 hasConceptScore W2134798699C2777420699 @default.
• W2134798699 hasConceptScore W2134798699C2777688143 @default.
• W2134798699 hasConceptScore W2134798699C2779234561 @default.
• W2134798699 hasConceptScore W2134798699C2779245376 @default.
• W2134798699 hasConceptScore W2134798699C2781087480 @default.
• W2134798699 hasConceptScore W2134798699C28748434 @default.
• W2134798699 hasConceptScore W2134798699C54355233 @default.
• W2134798699 hasConceptScore W2134798699C71924100 @default.
• W2134798699 hasConceptScore W2134798699C86803240 @default.
• W2134798699 hasConceptScore W2134798699C87073359 @default.
• W2134798699 hasConceptScore W2134798699C88972607 @default.
• W2134798699 hasIssue "3" @default.
• W2134798699 hasLocation W21347986991 @default.
• W2134798699 hasOpenAccess W2134798699 @default.
• W2134798699 hasPrimaryLocation W21347986991 @default.
• W2134798699 hasRelatedWork W1968259541 @default.
• W2134798699 hasRelatedWork W2004263337 @default.
• W2134798699 hasRelatedWork W2045259542 @default.
• W2134798699 hasRelatedWork W2060146325 @default.
• W2134798699 hasRelatedWork W2065519024 @default.
• W2134798699 hasRelatedWork W2167498945 @default.
• W2134798699 hasRelatedWork W2183685009 @default.
• W2134798699 hasRelatedWork W2378339968 @default.
• W2134798699 hasRelatedWork W3036398177 @default.
• W2134798699 hasRelatedWork W3134497530 @default.
• W2134798699 hasVolume "102" @default.
• W2134798699 isParatext "false" @default.
• W2134798699 isRetracted "false" @default.
• W2134798699 magId "2134798699" @default.
• W2134798699 workType "article" @default.